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FX

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By Targets:	Apoptosis (2) Bcl-2 Family (1) Dengue virus (1) Deubiquitinase (1) E1/E2/E3 Enzyme (1) Factor VIIa (1) Factor Xa (1) Flavivirus (1) Fluorescent Dye (1) Lactate Dehydrogenase (1) PPAR (1) Reactive Oxygen Species (1) Transthyretin (TTR) (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (3) Infection (1) Inflammation/Immunology (2) Neurological Disease (1)

12

Inhibitors & Agonists

1

Fluorescent Dye

1

Peptides

1

Inhibitory Antibodies

3

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

FX-11 15+ Cited Publications LDHA Inhibitor FX11	Lactate Dehydrogenase Apoptosis Reactive Oxygen Species	Cancer
FX-11 is a potent, selective, reversible and competitive lactate dehydrogenase A (LDHA) inhibitor, with a K_i of 8 μM. FX-11 reduces ATP levels and induces oxidative stress, ROS production and cell death. FX-11 shows antitumor activity in lymphoma and pancreatic cancer xenografts .

FX-909	PPAR	Cancer
FX-909 is a covalent peroxisome proliferator-activated receptor gamma (PPARG) inverse agonist. FX-909 can be used for the research of cancer .

FX1	Bcl-2 Family Apoptosis	Cancer
FX1 is a potent and specific BCL6 inhibitor, with an IC₅₀ of around 35 μM.

Tafamidis meglumine 2 Publications Verification FX-1006A	Transthyretin (TTR)	Neurological Disease
Tafamidis meglumine (Fx-1006A) is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC₅₀s of 2.7-3.2 μM. Tafamidis meglumine inhibits amyloidogenesis .

N-Phthaloyl-β-alanine	Others	Inflammation/Immunology
N-Phthaloyl-β-alanine (hapten FP) is an FX-type hapten without CH2S moiety. N-Phthaloyl-β-alanine can be coupled to OVA using the mixed anhydride method. N-Phthaloyl-β-alanine has more heterologies .

FX-171-C	Deubiquitinase	Cancer
FX-171-C is a noncompetitive Deubiquitinase inhibitor with an IC₅₀ of 1.4 µM .

FX-06 Fibrin-derived peptide Bβ15-42	Flavivirus Dengue virus	Cardiovascular Disease
FX-06 (Fibrin-derived peptide Bβ15-42) is a fibrin Bbeta chain-derived peptide. FX-06 binds to VE-cadherin and inhibits leukocyte transmigration and initiates VE-cadherin-mediated signaling. FX-06 can be used in the research of ischemia/reperfusion injury, Dengue shock syndrome (DSS) .

FM 1-43FX	Fluorescent Dye	Others
FM 1-43FX is a fluorescent membrane probe that contains an aliphatic amine which can react with aldehyde-based fixatives.

Denecimig Mim8	Factor Xa	Cardiovascular Disease
Denecimig (Mim8) is a novel activated coagulation factor VIII-mimetic human bispecific antibody with anti-FIXa and anti-FX arms that potently stimulates FX activation resulting in efficacious haemostasis in vitro and in vivo .

N-Phthaloylglycine Phthaloyl glycine	Others	Cancer
N-Phthaloylglycine (Phthaloyl glycine) is an FX-type hapten that attaches to free amine groups of proteins .

BMS-593214	Factor VIIa	Cardiovascular Disease
BMS-593214 is an active site-directed factor (F) VIIa inhibitor. BMS-593214 shows antithrombotic and antihaemostatic properties. BMS-593214 is a direct competitive inhibitor of human FVIIa and a non-competitive inhibitor of Viia-activated substrate FX. BMS-593214 prevents electroinduced carotid artery thrombosis (AT) and wire induced vena cava thrombosis (VT) .

RNF5-IN-1	E1/E2/E3 Enzyme	Infection Inflammation/Immunology Cancer
RNF5-IN-1 (FX12) is a selective RNF5 degrader. RNF5-IN-1 binds to RNF5 and inhibits its E3 activity, and promotes proteasomal degradation of RNF5 in an endoplasmic reticulum (ER)-associated degradation (ERAD) way in cells. RNF5-IN-1 inhibits α-1-antitrypsin (NHK) dislocation with an IC₅₀ value of 2.7 μM. RNF5-IN-1 can be used for research of cystic fibrosis, acute myeloid leukemia, and certain viral infections .

Cat. No.	Product Name	Type

FM 1-43FX	Fluorescent Dyes/Probes
FM 1-43FX is a fluorescent membrane probe that contains an aliphatic amine which can react with aldehyde-based fixatives.

Cat. No.	Product Name	Target	Research Area

FX-06 Fibrin-derived peptide Bβ15-42	Flavivirus Dengue virus	Cardiovascular Disease
FX-06 (Fibrin-derived peptide Bβ15-42) is a fibrin Bbeta chain-derived peptide. FX-06 binds to VE-cadherin and inhibits leukocyte transmigration and initiates VE-cadherin-mediated signaling. FX-06 can be used in the research of ischemia/reperfusion injury, Dengue shock syndrome (DSS) .

Cat. No.	Product Name	Target	Research Area

Denecimig Mim8	Factor Xa	Cardiovascular Disease
Denecimig (Mim8) is a novel activated coagulation factor VIII-mimetic human bispecific antibody with anti-FIXa and anti-FX arms that potently stimulates FX activation resulting in efficacious haemostasis in vitro and in vivo .

Species:	Human (2) Mouse (1)
Tag:	His (3)
Source:	HEK293 (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

	Coagulation Factor X/F10 Protein, Mouse (HEK293, His) rMuCoagulation factor X/FX, His; F10; Coagulation factor X; Stuart factor	Mouse	HEK293
	Coagulation Factor X/F10 Protein, a crucial vitamin K-dependent glycoprotein, is central to blood clotting. It produces Factor Xa, essential for converting prothrombin to thrombin, a process facilitated by factor Va, calcium, and phospholipid in the intricate cascade of blood coagulation. Coagulation Factor X/F10 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Coagulation Factor X/F10 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Coagulation Factor X/F10 Protein, Mouse (HEK293, His) is 461 a.a., with molecular weight of ~55.0 kDa.

	TMSB4X Protein, Human (His) FX; Hematopoietic system regulatory peptide; Prothymosin beta 4; PTMB 4; PTMB4; Seraspenide; T beta 4; T beta-4; TB4X; THYB 4; Thyb4; Thymosin beta 4; Thymosin beta 4 X chromosome; Thymosin beta 4 X linked; TMSB 4; TMSB4; Tmsb4x; TYB4_HUMAN	Human	E. coli
	TMSB4X proteins play a critical role in cytoskeletal organization, influencing actin dynamics by binding and sequestering actin monomers. As a potent inhibitor of actin polymerization, it affects the cytoskeleton. TMSB4X Protein, Human (His) is the recombinant human-derived TMSB4X protein, expressed by E. coli , with N-6*His labeled tag. The total length of TMSB4X Protein, Human (His) is 43 a.a., with molecular weight of ~13 kDa.

	TSTA3 Protein, Human (His) GDP-L-Fucose Synthase; GDP-4-Keto-6-Deoxy-D-Mannose-3; 5-Epimerase-4-Reductase; Protein FX; Red Cell NADP(H)-Binding Protein; Short-Chain Dehydrogenase/Reductase Family 4E Member 1; TSTA3; SDR4E1	Human	E. coli
	The TSTA3 protein plays a key role in catalyzing the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose. The process involves successive epimerase and reductase reactions, ultimately leading to the biosynthesis of GDP-fucose. TSTA3 Protein, Human (His) is the recombinant human-derived TSTA3 protein, expressed by E. coli , with C-6*His labeled tag. The total length of TSTA3 Protein, Human (His) is 321 a.a., with molecular weight of ~40.0 kDa.

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