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Results for "

GGT

" in MedChemExpress (MCE) Product Catalog:

25

Inhibitors & Agonists

2

Natural
Products

2

Recombinant Proteins

1

Antibodies

14

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P2997

    GGT, Porcine kidney

    Endogenous Metabolite Others
    γ-glutamyltransferase, Porcine kidney (GGT, Porcine kidney) is an enzyme located on the outer surface of the cell membrane. Gamma glutamyltransferase maintains the physiological concentration of cytoplasmic glutathione and the cell's defense against oxidative stress by cleaving extracellular glutathione and increasing the availability of amino acids. Gamma glutamyltransferase can be used as a biomaterial or organic compound for life science related research .
    γ-glutamyltransferase, Porcine kidney
  • HY-W016586

    AT-125; U-42126

    Parasite Infection Cancer
    Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties .
    Acivicin
  • HY-W016586A

    AT-125 hydrochloride; U-42126 hydrochloride

    Parasite Infection Cancer
    Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus, is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties .
    Acivicin hydrochloride
  • HY-W011391
    GPNA hydrochloride
    Maximum Cited Publications
    7 Publications Verification

    Apoptosis ASCT Cancer
    GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na +-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na +-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells .
    GPNA hydrochloride
  • HY-108467
    GGsTop
    2 Publications Verification

    Nahlsgen

    Others Cardiovascular Disease
    GGsTop (Nahlsgen) is a potent, non-toxic, highly selective and irreversible γ-GGT inhibitor, with a Ki of 170 μM for Human GGT. GGsTop shows a pKa of 9.71, also exhibits Kons of 150 and 51 M -1 s -1 against E.coli GGT and human GGT, respectively. GGsTop protects hepatic ischemia-reperfusion injury in rat model .
    GGsTop
  • HY-RS05403

    Small Interfering RNA (siRNA) Others

    GGT1 Human Pre-designed siRNA Set A contains three designed siRNAs for GGT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    GGT1 Human Pre-designed siRNA Set A
    GGT1 Human Pre-designed siRNA Set A
  • HY-RS05404

    Small Interfering RNA (siRNA) Others

    GGT5 Human Pre-designed siRNA Set A contains three designed siRNAs for GGT5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    GGT5 Human Pre-designed siRNA Set A
    GGT5 Human Pre-designed siRNA Set A
  • HY-RS05405

    Small Interfering RNA (siRNA) Others

    GGT6 Human Pre-designed siRNA Set A contains three designed siRNAs for GGT6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    GGT6 Human Pre-designed siRNA Set A
    GGT6 Human Pre-designed siRNA Set A
  • HY-RS05406

    Small Interfering RNA (siRNA) Others

    GGT7 Human Pre-designed siRNA Set A contains three designed siRNAs for GGT7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    GGT7 Human Pre-designed siRNA Set A
    GGT7 Human Pre-designed siRNA Set A
  • HY-P2997A

    GGT, Human liver

    Endogenous Metabolite Others
    γ-glutamyltransferase, Human liver (GGT, Human liver) is an enzyme located on the outer surface of the cell membrane. γ-glutamyltransferase maintains the physiological concentration of cytoplasmic glutathione and the cell's defense against oxidative stress by cleaving extracellular glutathione and increasing the availability of amino acids. γ-glutamyltransferase can be used as a biomaterial or organic compound for life science related research .
    γ-glutamyltransferase, Human liver
  • HY-128350

    Farnesyl Transferase Cancer
    FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT-1, respectively. FGTI-2734 can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors .
    FGTI-2734
  • HY-147081

    AGRO-100

    Histone Methyltransferase Bcl-2 Family Cancer
    AS 1411 (AGRO-100) is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. AS 1411 works by blocking the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells. AS 1411-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity .
    AS 1411
  • HY-118916

    Farnesyl Transferase Cancer
    FTI-2148 is a RAS C-terminal mimetic dual farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 1.4 nM and 1.7 μM, respectively .
    FTI-2148
  • HY-118916A

    Others Cancer
    FTI-2148 diTFA is a RAS C-terminal mimetic dual farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 1.4 nM and 1.7 μM, respectively .
    FTI-2148 diTFA
  • HY-148826

    ARC 183; BC 007

    Thrombin Others
    Rovunaptabin (ARC 183) is a DNA aptamer, which is a single-stranded DNA molecule consisting of 15 deoxynucleotides that forms well-defined three-dimensional configuration, allowing it to bind to thrombin with high affinity and specificity.
    Rovunaptabin
  • HY-150751

    ODN A151

    Toll-like Receptor (TLR) AIM2 Inflammation/Immunology
    ODN TTAGGG (A151), inhibitory oligonucleotide (ODN), is a TLR9, AIM2 and cGAS antagonist. ODN TTAGGG is immunosuppressive and inhibits AIM2 inflammasome activation, as well as cGAS activation, by competing with DNA. ODN TTAGGG can be used in the study of lupus erythematosus and other related autoimmune diseases. ODN TTAGGG sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3' .
    ODN TTAGGG
  • HY-128350A

    Farnesyl Transferase Cancer
    FGTI-2734 mesylate is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT, respectively. FGTI-2734 mesylate can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors .
    FGTI-2734 mesylate
  • HY-126710

    Others Cancer
    OU749 is a potent γ-glutamyl transpeptidase (GGT) inhibitor with a Ki value of 17.6 µM. OU749 shows cytotoxicity .
    OU749
  • HY-U00327

    Farnesyl Transferase Neurological Disease
    Prenyl-IN-1 is a protein prenylation inhibitor, especially a geranylgeranyltransferase (GGT) or a farnesyltransferase (FT) inhibitor, exhibiting potent activity against oxidative stress, and particularly in the treatment of Parkinson's Disease.
    Prenyl-IN-1
  • HY-146343

    Fluorescent Dye Inflammation/Immunology Cancer
    BMI-Glu is a selective γ-glutamyl transpeptidase (GGT) fluorescent probe with a Km of 69.63 µM. BMI-Glu has high sensitivity, good water solubility and biocompatibility .
    BMI-Glu
  • HY-148413
    Aprinocarsen sodium
    1 Publications Verification

    ISIS 3521 sodium

    PKC Cancer
    Aprinocarsen (ISIS 3521) sodium, a specific antisense oligonucleotide inhibitor of protein kinase C-alpha (PKC-α). Aprinocarsen sodium is a 20-mer oligonucleotide, it regulates cell differentiation and proliferation. Aprinocarsen sodium inhibits the growth of human tumor cell lines in nude mice. Aprinocarsen sodium shows the value as a chemotherapeutic compound of human cancers .
    Aprinocarsen sodium
  • HY-150725

    IFNAR TNF Receptor Infection Inflammation/Immunology Cancer
    ODN 1585 is a potent inducer of IFN and TNFα production. ODN 1585 is a potent stimulator of NK (natural killer) function. ODN 1585 increases CD8+ T-cell function, including the CD8+ T cell-mediated production of IFN-γ. ODN 1585 induces regression of established melanomas in mice. ODN 1585 can confer complete protection against malaria in mice. ODN 1585 can be used for acute myelogenous leukemia (AML) and malaria research. ODN 1585 can be used as a vaccine adjuvant .
    ODN 1585
  • HY-150748

    Toll-like Receptor (TLR) Inflammation/Immunology Cancer
    ODN D-SL01, a class B CpG ODN (oligodeoxynucleotide), is a TLR9 agonist. ODN D-SL01 has strong immunostimulatory activity in a variety of vertebrate species and has anticancer activity. ODN D-SL01 sequence: 5'- T-C-G-C-G-A-C-G-T-T-C-G-C-C-C-G-A-C-G-T-T-C-G-G-T-A-3' .
    ODN D-SL01
  • HY-150213

    CDK Inflammation/Immunology
    ODN BW001 is an oligodeoxynucleotide (ODN). ODN BW001 plays a regulatory role in the proliferation and activation of osteoblast .
    ODN BW001
  • HY-147217

    ISIS 505358

    HBV Infection
    Bepirovirsen is an antisense oligonucleotide targeting all HBV messenger RNAs. Bepirovirsen leads to reductions in HBV-derived RNAs, HBV DNA and viral proteins. Bepirovirsen can be used for the research of chronic HBV infection. Bepirovirsen binding site sequence (GCACTTCGCTTCACCTCTGC) .
    Bepirovirsen

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