ODN 1982 

ODN 1982 is a unmethylated oligodeoxyribonucleotide (ODN) with no CpG motif, can be used to prepare DNA vaccines. ODN 1982 inhibits R-848 signaling. ODN 1982 sequence: 5’-tccaggacttctctcaggtt-3’^[1][2].

ODN 1982 (0.1, 1 and 5 μM) has no influence on NF-κB induction in hTLR7-expressing HEK293 cells^[2].
ODN 1982 (0.1-10 μM; 24 h) together with Loxoribine does not induce IL-12p40 above the medium background, and yields few TNF⁺ monocytes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6364.10

207623-15-2

Solid

White to off-white

DNA, d(P-thio)(T-C-C-A-G-G-A-C-T-T-C-T-C-T-C-A-G-G-T-T)

[DNA, d(P-thio)(T-C-C-A-G-G-A-C-T-T-C-T-C-T-C-A-G-G-T-T)]

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Tudor D, et al. TLR9 pathway is involved in adjuvant effects of plasmid DNA-based vaccines. Vaccine. 2005 Jan 26;23(10):1258-64.  [Content Brief]

  [2]. Jurk M, et al. Modulating responsiveness of human TLR7 and 8 to small molecule ligands with T-rich phosphorothiate oligodeoxynucleotides. Eur J Immunol. 2006 Jul;36(7):1815-26.  [Content Brief]