2. Anti-infection
  3. Parasite
  4. Acivicin

Acivicin  (Synonyms: AT-125; U-42126)

Cat. No.: HY-W016586 Purity: ≥98.0%
COA Handling Instructions

Molarity Calculator

Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties.

For research use only. We do not sell to patients.

Acivicin Chemical Structure

Acivicin Chemical Structure

CAS No. : 42228-92-2

Size Price Stock Quantity
1 mg USD 150 In-stock
5 mg USD 460 In-stock
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Acivicin:

Acivicin Related Antibodies

Top Publications Citing Use of Products

View All Parasite Isoform Specific Products:

View All Isoforms
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2].

IC50 & Target

γ-glutamyl transpeptidase[1]
In Vitro

Acivicin (AT-125; 0.1-50 μM; 5 days) has an IC50 of 0.7 μM in human HepG2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Acivicin Related Antibodies
In Vivo

Acivicin (AT-125; 5 mg/kg; IP; twice weekly) reduces urinary γ-GT by 70-78%[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male pigmented Long-Evans rats weighed between 250 g and 300 g exposed to Toluene[3]
Dosage: 5 mg/kg
Administration: IP; twice weekly (monday and wednesday)
Result: Reduced urinary γ-GT by 70-78%.
Molecular Weight

178.57

Formula

C5H7ClN2O3
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

ClC1=NO[C@@]([C@H](N)C(O)=O)([H])C1
Structure Classification
Initial Source

Streptomyces sviceus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 6.67 mg/mL (37.35 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6000 mL 28.0002 mL 56.0004 mL
5 mM 1.1200 mL 5.6000 mL 11.2001 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.00%

COA (250 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.6000 mL 28.0002 mL 56.0004 mL 140.0011 mL
5 mM 1.1200 mL 5.6000 mL 11.2001 mL 28.0002 mL
10 mM 0.5600 mL 2.8000 mL 5.6000 mL 14.0001 mL
15 mM 0.3733 mL 1.8667 mL 3.7334 mL 9.3334 mL
20 mM 0.2800 mL 1.4000 mL 2.8000 mL 7.0001 mL
25 mM 0.2240 mL 1.1200 mL 2.2400 mL 5.6000 mL
30 mM 0.1867 mL 0.9333 mL 1.8667 mL 4.6667 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Acivicin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acivicin42228-92-2AT-125 U-42126AT125AT 125U42126U 42126U-42126Parasiteγ-glutamyltranspeptidaseGGTblood-brainbarrierInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Acivicin
Cat. No.:
HY-W016586
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.