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Results for "

Glucuronidase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	β-glucuronidase (1) Apoptosis (1) Bacterial (6) Biochemical Assay Reagents (3) Carbonic Anhydrase (3) Carboxylesterase (1) Cholinesterase (ChE) (1) Drug-Linker Conjugates for ADC (2) Endogenous Metabolite (4) Fluorescent Dye (7) Platelet-activating Factor Receptor (PAFR) (1)
By Research Areas:	Cancer (11) Infection (5) Inflammation/Immunology (5) Metabolic Disease (11) Neurological Disease (3)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Antibodies

Targets Recommended: β-glucuronidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103081

*β-Glucuronidase-IN-1*	Bacterial	Infection Cancer
β-Glucuronidase-IN-1 is a potent, selective, uncompetitive, and orally active E. coli bacterial β-glucuronidase inhibitor, exhibiting an IC₅₀ and a K_i of 283 nM and 164 nM, respectively .

HY-P2803

*Beta-glucuronidase* (Escherichia coli)** 1 Publications Verification	Others	Metabolic Disease
Beta-glucuronidase is an important lysosomal enzyme involved in the degradation of glucuronate-containing glycosaminoglycan .

HY-P2803A

*Beta-glucuronidase* (bovine liver)** 1 Publications Verification	Others	Metabolic Disease
Beta-glucuronidase is an important lysosomal enzyme involved in the degradation of glucuronate-containing glycosaminoglycan .

HY-E70101

α-Glucuronidase	Others	Others
α-Glucuronidase plays an essential role in the full enzymatic hydrolysis of hemicellulose. α-Glucuronidase cleaves the attached MeGlcA moiety from the xylose .

HY-151166

*β-Glucuronidase-IN-2*	Bacterial	Cancer
β-Glucuronidase-IN-2 is a potent E. coli *β-glucuronidase* inhibitor with an IC₅₀ value of 0.24 μM, an K_i value of 1.09 μM. β-Glucuronidase-IN-2 shows antiproliferative activity. β-Glucuronidase-IN-2 has the potential for the research of anti-cancer and anti-inflammatory therapies .

HY-150976

*β-Glucuronidase/hCAII-IN-1*	Carbonic Anhydrase	Neurological Disease Metabolic Disease Cancer
β-Glucuronidase/hCAII-IN-2 (Compound 12e) is a potent *β-glucuronidase* and hCA II inhibitor with an IC₅₀ of 440.1 μM and 4.91 μM, respectively .

HY-150977

*β-Glucuronidase/hCAII-IN-2*	Carbonic Anhydrase	Neurological Disease Metabolic Disease Cancer
β-Glucuronidase/hCAII-IN-2 (Compound 12e) is a potent *β-glucuronidase* and hCA II inhibitor with an IC₅₀ of 670.7 μM and 21.77 μM, respectively .

HY-161341

*β-Glucuronidase* responsive conjugate 1**	Others	Cancer
β-Glucuronidase responsive conjugate 1 (compound 3) is a well-balanced photosensitizer which has photodynamic activity. β-Glucuronidase responsive conjugate 1 inhibits T-24 cell viability and growth with an IC₅₀ of 0.2 μM. β-Glucuronidase responsive conjugate 1 can used to study bladder cancers .

HY-P2803B

*Beta-glucuronidase* (helix pomatia)**	β-glucuronidase	Metabolic Disease
Beta-glucuronidase (helix pomatia) is a glycosyl hydrolase that hydrolyzes β-glucuronic acid and sulfate esters in urine and other biological fluids, and then releases β-glucuronate .

HY-N9975

4'',5''-Dehydroisopsoralidin	Others	Inflammation/Immunology Cancer
4'',5''-Dehydroisopsoralidin is a *β-glucuronidase* inhibitor (IC₅₀: 6.3 μM). 4'',5''-Dehydroisopsoralidin has anti-inflammatory and anti-oxidative effects. 4'',5''-Dehydroisopsoralidin can be used in the research of inflammation and cancners .

HY-N1735

2′-Hydroxygenistein	Others	Inflammation/Immunology
2′-Hydroxygenistein is a natural product that can be isolated from Crotalaria pallida and C. assamica. 2′-Hydroxygenistein shows anti-inflammatory activity. 2′-Hydroxygenistein shows significant concentration-dependent inhibitory effects on the release of *β-glucuronidase* and lysozyme from rat neutrophils, with IC₅₀ values of 5.9 ± 1.4 and 9.7 ± 3.5 μM, respectively .

HY-N7529

Siastatin B	Endogenous Metabolite	Others
Siastatin B is an effective broad-spectrum glycosidase inhibitor that can effectively inhibit the activities of sialidase, *β-D-glucuronidase, N-acetyl-glucosaminidase, β-glucuronidase, and human heparinase* .

HY-137426A

Phenolphthalein glucuronide sodium	Biochemical Assay Reagents	Others
Phenolphthalein glucuronide sodium is a substrate to determine the β –glucuronidase .

HY-D1460

Fluorescein Di-β-D-Glucuronide	Bacterial	Infection
Fluorescein Di-β-D-Glucuronide, a fluorescent probe, can be utilized to non-invasively image the intestinal bacterial β-glucuronidase activity in nude mice. Fluorescein Di-β-D-Glucuronide-based imaging reveals the in vitro and in vivo activity of intestinal bacterial β-glucuronidase, which would facilitate pharmacodynamic studies of specific bacterial β-glucuronidase inhibitors in animal studies .

HY-162884

EcGUS-IN-1	Others	Infection
EcGUS-IN-1 (Compound E-9) is a non-competitive *β-glucuronidase* inhibitor, with an IC₅₀ of 2.68 μM and a K_i value of 1.64 μM. EcGUS-IN-1 can improve gastrointestinal adverse events (GIAE) caused by Escherichia coli infection by inhibiting E. coli *β-glucuronidase* activity .

HY-D0164

Naphthol AS-BI	Fluorescent Dye
Naphthol AS-BI is a substrate of β-glucuronidase and produces a bright red effect after staining biological tissues.

HY-134453A

D-Saccharic acid 1,4-lactone hydrate 1 Publications Verification	Apoptosis	Cancer
D-Saccharic acid 1,4-lactone hydrate is an orally active *β-glucuronidase* inhibitor (IC₅₀=48.4 μM). D-Saccharic acid 1,4-lactone hydrate can be used as a standard agent compared with novel β-glucuronidase inhibitors. D-Saccharic acid 1,4-lactone hydrate possesses anticarcinogenic, detoxifying, and antioxidant properties .

HY-D1578

C12FDGlcU	Fluorescent Dye	Others
C12FDGlcU is a lipophilic analog of fluorescein di-β-D-glucuronic acid. C12FDGlcU can be useful for the detection of *β-glucuronidase* (GUS) gene expression. C12FDGlcU can enter the cells and then be cleaved by β-glucuronidase, generating the yellow-colored, green-fluorescent fluorescein (Abs/Em of the reaction product: 495/518 nm) .

HY-N2998

Ganoderenic acid A	Others	Metabolic Disease
Ganoderenic acid A is a lanostane-type triterpene. Ganoderenic acid A is a potent inhibitor of *β-glucuronidase*. Ganoderenic acid A has a potent hepatoprotective effect against CCl4-induced liver injury .

HY-N1322

Sanggenol A	Others	Others
Sanggenol A acts as a dual inhibitor of nitrofuranone reduction mediated by the intestinal microbial nitrification reductases EcNfsA and EcNfsB. In addition, Sanggenol A is also an effective inhibitor of intestinal bacterial β-glucuronidase .

HY-155411

HPSE1-IN-2	Endogenous Metabolite	Metabolic Disease
HPSE1-IN-2 (compound 2) is a Heparanase-1 (HPSE1) inhibitor that also inhibits exo-β-d-glucuronidase (GUSβ) and glucocerebrosidase (GBA) activity .

HY-150973

hCAII-IN-4	Carbonic Anhydrase	Neurological Disease Metabolic Disease Cancer
hCAII-IN-4 (Compound 12j) is a potent hCA II inhibitor with an IC₅₀ of 7.78 μM. hCAII-IN-4 also inhibits *β-glucuronidase* with an IC₅₀ of 773.9 μM .

HY-155410

HPSE1-IN-1	Endogenous Metabolite	Metabolic Disease
HPSE1-IN-1 (compound 16) is a selective inhibitor of Heparanase-1 (HPSE1) with moderate inhibitory activity against exo-β-d-glucuronidase (GUSβ) and glucocerebrosidase (GBA) .

HY-N2247A

(+)-Guaiacin	Platelet-activating Factor Receptor (PAFR)	Metabolic Disease
(+)-Guaiacin is a compound extracted of the bark of Machilus wangchiana Chun. (Lauraceae). (+)-Guaiacin shows potent in vitro activities against the release of β-glucuronidase in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor (PAF) .

HY-128943

MAC glucuronide phenol-linked SN-38	Drug-Linker Conjugates for ADC	Cancer
MAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) agent linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC₅₀ values of 113 and 67 ng/mL, respectively.Albumin-coupled MAC glucosidol-linked SN-38 shows good stability in mouse plasma .

HY-W039892

4-Nitrophenyl β-D-glucuronide pNPG_1	Others	Others
4-Nitrophenyl β-D-glucuronide (pNPG_1) is aderivative of 4-nitrophenol 4-Nitrophenyl β-D-glucuronide is a chromogenic compound and is the chromogenic substrate for β-glucuronidase .

HY-N3413

Kushenol X	Carboxylesterase	Metabolic Disease
Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent *β-glucuronidase* and human carboxylesterase 2 (hCE2) inhibitor with IC₅₀s of 2.07 μM and 3.05 μM, respectively .

HY-N1733

2′-Hydroxydaidzein	Others	Inflammation/Immunology
2′-Hydroxydaidzein is a metabolite. 2′-Hydroxydaidzein inhibits the release of chemical mediator from inflammatory cells. 2′-Hydroxydaidzein significantly inhibits lysozyme and β-glucuronidase release from rat neutrophils, which is stimulated with fMLP/CB, respectively .

HY-D0935A

4-Methylumbelliferyl-β-D-glucuronide hydrate MUG	Fluorescent Dye	Others
4-Methylumbelliferyl-β-D-glucuronide hydrate is a fluorogenic substrat (λ_ex=362 nm, λ_em=445 nm). 4-Methylumbelliferyl-β-D-glucuronide hydrate has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli .

HY-D0935

4-Methylumbelliferyl-β-D-glucuronide	Fluorescent Dye	Others
4-Methylumbelliferyl-β-D-glucuronide is a fluorogenic substrat (λ_ex=362 nm, λ_em=445 nm). 4-Methylumbelliferyl-β-D-glucuronide has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli .

HY-137816

6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium	Others	Others
6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium salt is a chromogenic substrate for β-glucuronidase. 6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium salt produces a salmon colored precipitate upon cleavage .

HY-113245

3-Indolyl-β-D-glucuronide	Endogenous Metabolite	Others
3-Indolyl-β-D-glucuronide, a chromogenic substrate for β-D-glucuronidase, employs in the detection and enumeration of E. coli, yielding a blue precipitate upon cleavage. 3-Indolyl-β-D-glucuronide in? patients' plasma act as a new indicator of renal failure .

HY-151168

3-Chlorogentisyl alcohol	Bacterial	Inflammation/Immunology Cancer
3-Chlorogentisyl alcohol is a potent E. coli *β-glucuronidase* inhibitor with an IC₅₀ value of 0.74 μM, an K_i value of 0.58 μM. 3-Chlorogentisyl alcohol shows antiproliferative activity. 3-Chlorogentisyl alcohol has the potential for the research of anti-cancer and anti-inflammatory therapies .

HY-15935

*X-Gluc* Dicyclohexylamine**	Fluorescent Dye	Others
X-Gluc Dicyclohexylamine is a dye reagent for the detection of β-glucuronidase, an enzyme produced by Escherichia coli. X-Gluc sodium can be used to detect E. coli contamination in food, water and the urinary tract. X-Gluc sodium is also widely used in molecular biology experiments to label and detect the expression of target genes (GUS reporter system) .

HY-W283888

5-Bromo-4-chloro-1H-indol-3-yl nonanoate	Biochemical Assay Reagents	Others
5-Bromo-4-chloro-1H-indol-3-yl nonanoate is a fluorescent substrate used to detect enzymes. The substrate reacts with various enzymes to produce a fluorescent product, which has been shown to be active against β-galactosidase, α-chymotrypsin, and β-glucuronidase.

HY-15935C

*X-Gluc* sodium**	Fluorescent Dye	Others
X-Gluc sodium is a dye reagent for the detection of *β-glucuronidase* (GUS), an enzyme produced by E. coli. X-Gluc sodium can be used to detect E. coli contamination in food, water and the urinary tract (GUS as a specific detection indicator). X-Gluc sodium is also widely used in molecular biology experiments to label and detect the expression of target genes (reacts with the GUS gene, appears blue) .

HY-148044

UNC10201652	Bacterial	Infection
UNC10201652 is a potent Loop 1 (L1)-specific gut bacterial β-glucuronidase (GUSs) inhibitor with an IC₅₀ value of 0.117 μM for E. coli GUS. UNC10201652 can block SN-38 glucuronide (HY-126373) processing only in individuals whose fecal gut microbiota is highly abundant in L1 GUS enzymes .

HY-15935B

*X-Gluc* cyclohexanamine**	Fluorescent Dye	Others
X-Gluc cyclohexanamine is a dye reagent for the detection of *β-glucuronidase* (GUS), an enzyme produced by E. coli. X-Gluc cyclohexanamine can be used to detect E. coli contamination in food, water and the urinary tract (GUS as a specific detection indicator). X-Gluc cyclohexanamine is also widely used in molecular biology experiments to label and detect the expression of target genes (reacts with the GUS gene, appears blue) .

HY-119609

Ilicicolin C	Bacterial Cholinesterase (ChE)	Infection
Ilicicolin C exhibits antibacterial activity against Pseudomonas syringae with IC₅₀ of 28.5 µg/mL. Ilicicolin C exhibits weak inhibitory activities against acetylcholinesterase (AChE) and *β-glucuronidase* with IC₅₀ of 30-43 µg/mL. Ilicicolin C exhibits weak cytoxicity in human lung fibroblasts with IC₅₀ of 64-120 µg/mL. Ilicicolin C affects seed germination and root tip growth of lettuce .

HY-W154341

3-Indolyl-β-D-glucuronide cyclohexanamine	Biochemical Assay Reagents	Others
3-Indolyl-β-D-glucuronide cyclohexanamine is the glucose component of X-Gluc staining buffer. 3-Indolyl-β-D-glucuronide cyclohexanamine can be used to detect gene expression. The active ingredient of the stain, β-Glucuronidase (GUS), reacts with the enzyme, causing the target gene to appear blue-purple in tissues or cells, so that the expression level and tissue distribution of the gene can be visually observed .

HY-N6851

Glycyrrhetic acid 3-O-β-D-glucuronide Glycyrrhetic acid 3-O-mono-β-D-glucuronide; 3-monoglucuronyl-glycyrrhetinic acid	Others	Inflammation/Immunology
Glycyrrhetic acid 3-O-β-D-glucuronide, isolated from glycyrrhiza, is an important derivative of glycyrrhizin (GL) with an anti -allergic activity . Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) shows that β-glucuronidases (β-GUS) are key GAMG-producing enzymes, displaying a high potential to convert GL directly into GAMG .Glycyrrhetic acid 3-O-β-D-glucuronide is valuable as a sweetener.

HY-155313

β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE	Drug-Linker Conjugates for ADC	Cancer
β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE (compound 20) is auristatins-glucuronide conjugate. Antitumor agent-122 shows in vitro antiproliferative activities against β-glucuronidase pretreated and untreated cancer cells with an IC₅₀ value of 5.7 nM - 9.7 nM. Antitumor agent-122 shows potent antitumor efficacy in HCT-116 xenograft mouse model without inducing side effects .

Cat. No.	Product Name	Type

HY-D0935A

4-Methylumbelliferyl-β-D-glucuronide hydrate MUG	Chromogenic Substrates
4-Methylumbelliferyl-β-D-glucuronide hydrate is a fluorogenic substrat (λ_ex=362 nm, λ_em=445 nm). 4-Methylumbelliferyl-β-D-glucuronide hydrate has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli .

HY-15935

*X-Gluc* Dicyclohexylamine**	Chromogenic Assays
X-Gluc Dicyclohexylamine is a dye reagent for the detection of β-glucuronidase, an enzyme produced by Escherichia coli. X-Gluc sodium can be used to detect E. coli contamination in food, water and the urinary tract. X-Gluc sodium is also widely used in molecular biology experiments to label and detect the expression of target genes (GUS reporter system) .

HY-15935C

*X-Gluc* sodium**	Fluorescent Dyes/Probes
X-Gluc sodium is a dye reagent for the detection of *β-glucuronidase* (GUS), an enzyme produced by E. coli. X-Gluc sodium can be used to detect E. coli contamination in food, water and the urinary tract (GUS as a specific detection indicator). X-Gluc sodium is also widely used in molecular biology experiments to label and detect the expression of target genes (reacts with the GUS gene, appears blue) .

X-Gluc sodium

Fluorescent Dyes/Probes

X-Gluc sodium is a dye reagent for the detection of β-glucuronidase (GUS), an enzyme produced by E. coli. X-Gluc sodium can be used to detect E. coli contamination in food, water and the urinary tract (GUS as a specific detection indicator). X-Gluc sodium is also widely used in molecular biology experiments to label and detect the expression of target genes (reacts with the GUS gene, appears blue) .

HY-D1460

Fluorescein Di-β-D-Glucuronide

Fluorescent Dyes/Probes

Fluorescein Di-β-D-Glucuronide, a fluorescent probe, can be utilized to non-invasively image the intestinal bacterial β-glucuronidase activity in nude mice. Fluorescein Di-β-D-Glucuronide-based imaging reveals the in vitro and in vivo activity of intestinal bacterial β-glucuronidase, which would facilitate pharmacodynamic studies of specific bacterial β-glucuronidase inhibitors in animal studies .

HY-D0164

Naphthol AS-BI	Dyes
Naphthol AS-BI is a substrate of β-glucuronidase and produces a bright red effect after staining biological tissues.

HY-D1578

C12FDGlcU	Fluorescent Dyes/Probes
C12FDGlcU is a lipophilic analog of fluorescein di-β-D-glucuronic acid. C12FDGlcU can be useful for the detection of *β-glucuronidase* (GUS) gene expression. C12FDGlcU can enter the cells and then be cleaved by β-glucuronidase, generating the yellow-colored, green-fluorescent fluorescein (Abs/Em of the reaction product: 495/518 nm) .

Cat. No.	Product Name	Type

HY-D0935

4-Methylumbelliferyl-β-D-glucuronide	Biochemical Assay Reagents
4-Methylumbelliferyl-β-D-glucuronide is a fluorogenic substrat (λ_ex=362 nm, λ_em=445 nm). 4-Methylumbelliferyl-β-D-glucuronide has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli .

HY-W283888

5-Bromo-4-chloro-1H-indol-3-yl nonanoate	Cell Assay Reagents
5-Bromo-4-chloro-1H-indol-3-yl nonanoate is a fluorescent substrate used to detect enzymes. The substrate reacts with various enzymes to produce a fluorescent product, which has been shown to be active against β-galactosidase, α-chymotrypsin, and β-glucuronidase.

Cat. No.	Compare	Product Name	Species	Source

HY-P70258

	*Beta-glucuronidase/GUSB Protein, E.coli (N-His, solution)* rE.coBeta-Glucuronidase/GUSB, His; Beta-Glucuronidase; uidA; GUS	E.coli	E. coli
	The beta-glucuronidase/GUSB protein displays activity with PNPG and 4-methylumbelliferyl-glucuronide. It scavenges glucuronate from various xenobiotic and endobiotic glucuronides in the GI tract, utilizing diverse carbon sources. As part of the GI microbiome, it can reactivate glucuronide drug conjugates, potentially harming the GI tract. Beta-glucuronidase/GUSB Protein, E.coli (N-His, solution) is the recombinant E. coli-derived Beta-glucuronidase/GUSB protein, expressed by E. coli , with N-6*His labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83108

	*beta Glucuronidase* Antibody (YA2853)** GUSB; Beta-Glucuronidase; Beta-G1	WB, IHC-P, ICC/IF, FC	Human
	beta Glucuronidase Antibody (YA2853) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2853), targeting beta Glucuronidase, with a predicted molecular weight of 75 kDa (observed band size: 78 kDa). beta Glucuronidase Antibody (YA2853) can be used for WB, IHC-P, ICC/IF, FC experiment in human background.