2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. β-glucuronidase

β-glucuronidase

GUSB

β-glucuronidase is a glycoside hydrolase widely distributed in mammalian tissues, body fluids, microbiota, plants, fish, insects and mollusks. β-glucuronidase belongs to GH family 1, 2, 30, 79, 154 and GH-A. β-glucuronidase can hydrolyze estrogen glucuronides, regulate the enterohepatic circulation and reabsorption of estrogen, and affect estrogen metabolism. β-glucuronidase can also hydrolyze the extracellular sugar residues on the TRPV5 channel, trapping it in the plasma membrane, maintaining calcium channel activity and membrane calcium permeability. This target is related to many disease areas. For example, in cancer, its increased activity is related to the occurrence and development of colorectal cancer, breast cancer, ovarian cancer, etc.; in metabolic diseases, it is related to diabetes and its induced periodontitis; in inflammatory diseases, it involves bacterial peritonitis, bacterial meningitis, pelvic inflammatory disease, etc.; in addition, it is also related to diseases such as endometriosis[1][2][3][4][5][6][7].

β-glucuronidase Related Products (8):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P2803
    Beta-glucuronidase (Escherichia coli)
    Beta-glucuronidase is an important lysosomal enzyme involved in the degradation of glucuronate-containing glycosaminoglycan.
    Beta-glucuronidase (Escherichia coli)
  • HY-W039892
    4-Nitrophenyl β-D-glucuronide
    		Substrate 99.13%
    4-Nitrophenyl β-D-glucuronide (pNPG_1) is aderivative of 4-Nitrophenol. 4-Nitrophenyl β-D-glucuronide is the chromogenic substrate for β-glucuronidase.
    4-Nitrophenyl β-D-glucuronide
  • HY-P2803A
    Beta-glucuronidase (bovine liver)
    Beta-glucuronidase is an important lysosomal enzyme involved in the degradation of glucuronate-containing glycosaminoglycan.
    Beta-glucuronidase (bovine liver)
  • HY-W345885
    Saccharic acid
    		Inhibitor ≥98.0%
    Saccharic acid is a competitive inhibitor of β-glucuronidase. Saccharic acid considerably retards hydrolysis of the glucuronide of 'l-ortho-hydroxyphenylazo-2-naph-thol' by frozen mouse kidney sections, but has no effect on liver regeneration following damage and on growth in infant mice.
    Saccharic acid
  • HY-137816
    6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium
    		Substrate
    6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium salt is a chromogenic substrate for β-glucuronidase. 6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium salt produces a salmon colored precipitate upon cleavage.
    6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium
  • HY-119621
    Aceglatone
    		Inhibitor
    Aceglatone, an antineoplastic agent, is a β-glucuronidase inhibitor. Aceglatone is a compound that inhibits colon carcinogenesis and prevents the induction of colon cancer by inhibiting the hydrolysis of glucuronides. Aceglatone reduces cell proliferation, induces apoptosis and inhibits DNA synthesis in human colon cancer cells.
    Aceglatone
  • HY-P2803B
    Beta-glucuronidase (helix pomatia)
    		Chemical
    Beta-glucuronidase (helix pomatia) is a glycosyl hydrolase that hydrolyzes β-glucuronic acid and sulfate esters in urine and other biological fluids, and then releases β-glucuronate.
    Beta-glucuronidase (helix pomatia)
  • HY-162884
    EcGUS-IN-1
    		Inhibitor
    EcGUS-IN-1 (Compound E-9) is a non-competitive β-glucuronidase inhibitor, with an IC50 of 2.68 μM and a Ki value of 1.64 μM. EcGUS-IN-1 can improve gastrointestinal adverse events (GIAE) caused by Escherichia coli infection by inhibiting E. coli β-glucuronidase activity.
    EcGUS-IN-1