4'',5''-Dehydroisopsoralidin

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4'',5''-Dehydroisopsoralidin is a β-glucuronidase inhibitor (IC₅₀: 6.3 μM). 4'',5''-Dehydroisopsoralidin has anti-inflammatory and anti-oxidative effects. 4'',5''-Dehydroisopsoralidin can be used in the research of inflammation and cancners.

For research use only. We do not sell to patients.

4'',5''-Dehydroisopsoralidin Chemical Structure

CAS No. : 65639-51-2

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Description	4'',5''-Dehydroisopsoralidin is a β-glucuronidase inhibitor (IC₅₀: 6.3 μM). 4'',5''-Dehydroisopsoralidin has anti-inflammatory and anti-oxidative effects. 4'',5''-Dehydroisopsoralidin can be used in the research of inflammation and cancners^[1]^[2].
IC₅₀ & Target	β-glucuronidase^[1]
In Vitro	4'',5''-Dehydroisopsoralidin (compound 5, 15 min) inhibits the release of β-glucuronidase in polymorphonuclear leukocytes (PMNs) of rats, with an IC₅₀ value of 6.3 μM^[1]. 4'',5''-Dehydroisopsoralidin (compound 9, 24 h) shows weak cytotoxicity (IC₅₀: >50 μM) to H4IIE, HCT116, C6 cells^[2]. 4'',5''-Dehydroisopsoralidin (25 μM, 1h) causes significant radical scavenging in H4IIE rat hepatoma cells (TEAC assay)^[2]. 4'',5''-Dehydroisopsoralidin (compound 5, 15 μM, 60 h) increases lifespan in P. corylifolia (MEP assay)^[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 4'',5''-Dehydroisopsoralidin Related Antibodies
Molecular Weight	334.32
Formula	C₂₀H₁₄O₅
CAS No.	65639-51-2
SMILES	O=C1OC2=CC3=C(C=C2C4=C1C5=C(C=C(C=C5)O)O4)C=CC(C)(C)O3
Structure Classification	Phenylpropanoids Coumarins
Initial Source	Plants Solanaceae Solanum lyratum Thunberg
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (271 KB) Handling Instructions (2659 KB)
References	[1]. De-Wu Zhang, et al. Solalyratins A and B, new anti-inflammatory metabolites from Solanum lyratum. J Nat Med. 2012 Apr;66(2):362-6. [Content Brief] [2]. Christian Limper, et al. Compounds isolated from Psoralea corylifolia seeds inhibit protein kinase activity and induce apoptotic cell death in mammalian cells. J Pharm Pharmacol. 2013 Sep;65(9):1393-408. [Content Brief] [3]. Tong-Hong Wang, et al. The flavonoid corylin exhibits lifespan extension properties in mouse. Nat Commun. 2022 Mar 9;13(1):1238. [Content Brief]