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Hop-17(21)-en-3-ol

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (2) Apoptosis (5) Bacterial (1) BCRP (1) Caspase (1) CDK (1) CMV (2) COX (2) Glucosidase (2) Histone Demethylase (1) HSV (4) Influenza Virus (2) mGluR (1) Microtubule/Tubulin (1) Parasite (3)
By Research Areas:	Cancer (13) Infection (9) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N11769

Xanthohumol C	Others	Others
Xanthohumol C is a prenylchalcone, that can be isolated from the hops of Humulus lupulus .

HY-N2584A

Isoxanthohumol 1 Publications Verification	HSV	Infection Cancer
Isoxanthohumol is a prenylflavonoid from hops and beer. Isoxanthohumol exhibits an antiproliferative activity against several human cancer cell lines. Isoxanthohumol inhibits the development of lung metastatic foci in tumor-challenged animals. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV) .

HY-N4035

Hop-17(21)-en-3-ol (3β)-A'-Neogammacer-17(21)-en-3-ol	Others	Others
Hop-17(21)-en-3-ol ((3β)-A'-Neogammacer-17(21)-en-3-ol) is a Monoterpenoids product that can be isolated from the herbs of Xanthium sibiricum .

HY-N13225

Hops Flower Extract	Others	Others
Hops Flower Extract is the extract of Hops Flower.

HY-N10440

*3-Oxo-hop-22(29)-ene*	Glucosidase	Infection Inflammation/Immunology
3-Oxo-hop-22(29)-ene is a yeast α-glucosidase inhibitor. 3-Oxo-hop-22(29)-ene shows a moderate effect on the viability of T. cruzi and L. mexicana. 3-Oxo-hop-22(29)-ene shows marginal activity of anti-inflammatory .

HY-N10441

*3β-Hydroxy-hop-22(29)-ene*	Parasite	Infection
3β-Hydroxy-hop-22(29)-ene (compound 3) is a potent antiparasitic agent. 3β-Hydroxy-hop-22(29)-ene shows moderate activity against Trypanosoma cruzi and Leishmania mexicana .

HY-N10439

*3β-Acetoxy-hop-22(29)-ene*	Glucosidase	Inflammation/Immunology
3β-Acetoxy-hop-22(29)-ene (compound 1) is a potent anti-inflammatory agent. 3β-Acetoxy-hop-22(29)-ene shows high inhibitory activity of yeast α-glucosidase, with an IC₅₀ of 5.74 μM. 3β-Acetoxy-hop-22(29)-ene inhibits MPO (myeloperoxidase) activity in a dose-dependent manner in mouse ear edema model induced by 12-O-tetradecanoylphorbol acetate (TPA), with an IC₅₀ of 0.23 μmol/ear .

HY-N9140

Hulupinic acid	Others	Others
Hulupinic acid is a prominent oxidation product of hop acids .

HY-124901

Tetrasul	Parasite	Infection
Tetrasul is an acaricide. Tetrasul inhibits Tetranychus urticae and aphids on hops. Tetrasul has also been used in research of erythematous (type one) rosacea .

HY-124901R

Tetrasul (Standard)	Parasite	Infection
Tetrasul (Standard) is the analytical standard of Tetrasul. This product is intended for research and analytical applications. Tetrasul is an acaricide. Tetrasul inhibits Tetranychus urticae and aphids on hops. Tetrasul has also been used in research of erythematous (type one) rosacea .

HY-N2584AR

Isoxanthohumol (Standard)	HSV	Infection Cancer
Isoxanthohumol (Standard) is the analytical standard of Isoxanthohumol. This product is intended for research and analytical applications. Isoxanthohumol is a prenylflavonoid from hops and beer. Isoxanthohumol exhibits an antiproliferative activity against several human cancer cell lines. Isoxanthohumol inhibits the development of lung metastatic foci in tumor-challenged animals. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV) .

HY-N3951

Glochidone	Others	Cancer
Glochidone is an anti-cancer agent with IC₅₀s of 5.52 μM and 7.84 μM against HOP-62 and EPLC-272H cells, respectively .

HY-N2584

(2S)-Isoxanthohumol	Others	Cancer
(2S)-Isoxanthohumol is a microbial biotransformed metabolite of the hop prenylflavanone Isoxanthohumol .

HY-147901

KDM1/CDK1-IN-1	Histone Demethylase CDK Apoptosis Caspase	Cancer
KDM1/CDK1-IN-1 (compound 4) is a potent KDM1 and CDK1 inhibitor, with IC₅₀ values of 0.096 and 0.078 μM, respectively.KDM1/CDK1-IN-1 induces cell cycle arrest at G2/M phase and apoptosis in HOP-92 cells. KDM1/CDK1-IN-1 exhibits potent cytotoxic activity against the CCRF-CEM, HOP-92 and Hep-G2 cells, with IC₅₀ values of 16.34, 3.45 and 7.79 μM, respectively .

HY-N10867

β-Acids colupulone	Others	Others
β-Acids colupulone is the bitter substance. β-Acids colupulone can be isolated from hops .

HY-124923

Lupulone	Bacterial	Infection Cancer
Lupulone is a beta-acid from the hop plant H. lupulus with diverse biological activities including antibacterial, antioxidant, and anticarcinogenic properties .

HY-122966

Desmethylxanthohumol 1 Publications Verification	Apoptosis	Cancer
Desmethylxanthohumol is a prenylated hydroxychalcone isolated from hop cones (Humulus lupulus L.). Desmethylxanthohumol is a powerful apoptosis inducing agent. Desmethylxanthohumol has antiplasmodial, antiproliferative, and antioxidant bioactivities .

HY-N10668

2-(3-Hydroxy-2-oxoindolin-3-yl)-acetic acid	Others	Others
2-(3-Hydroxy-2-oxoindolin-3-yl)-acetic acid (compound 29) is a natural polyphenol compound found in hop bract .

HY-N1066

Xanthohumol D 1 Publications Verification	Others	Cancer
Xanthohumol D, isolated from hops, is an inhibitor of quinone reductase-2 (QR-2) with the IC₅₀ value of 110 μM, and binds to the active site of QR-2. Xanthohumol D shows antiproliferative activity on human cancer cell lines in vitro .

HY-149388

Anticancer agent 139	Microtubule/Tubulin	Cancer
Anticancer agent 139 (Compound 6h) has potent anticancer activity. Anticancer agent 139 displayed a π–cationic interaction with the residue Lys352 of Tublin. Anticancer agent 139 has good anticancer activity against SNB-19, OVCAR-8, and NCI-H40 with PGIs of 86.61, 85.26, and 75.99, respectively. Anticancer agent 139 also has moderate anticancer activity against HOP-62, SNB-75, ACHN, NCI/ADR-RES, 786-O, A549/ATCC, HCT-116, and MDA-MB-231 with PGIs of 67.55, 65.46, 59.09, 59.02, 57.88, 56.88, 56.53, 56.4, and 51.88 respectively .

HY-N1067

Xanthohumol Maximum Cited Publications 8 Publications Verification	COX Acyltransferase Apoptosis HSV CMV Influenza Virus	Infection Cancer
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).

HY-N2787

8-Prenylnaringenin 1 Publications Verification	Apoptosis	Cancer
8-prenylnaringenin is a prenylflavonoid isolated from hop cones Humulus lupulus, with cytotoxicity. 8-prenylnaringenin has anti-proliferative activity against HCT-116 colon cancer cells via induction of intrinsic and extrinsic pathway-mediated apoptosis. 8-Prenylnaringenin also promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice .

HY-N1067R

Xanthohumol (Standard)	COX Acyltransferase Apoptosis HSV CMV Influenza Virus	Infection Cancer
Xanthohumol (Standard) is the analytical standard of Xanthohumol. This product is intended for research and analytical applications. Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).

HY-122416

6,8-Diprenylnaringenin Lonchocarpol A; Senegalensin	BCRP	Metabolic Disease Cancer
6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and ³H-Methotrexate transport (IC₅₀=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin .

HY-130630

mGluR2 modulator 1	mGluR	Neurological Disease
mGluR2 modulator 1 (compound 95) is a potent and BBB-penetrated mGluR2 (metabotropic glutamate receptor-2) positive allosteric modulator, with an EC₅₀ of 0.03 μM. mGluR2 modulator 1 can be used for psychosis research .

Xanthohumol C	Structural Classification Humulus lupulus L. Source classification Phenols Polyphenols Plants Moraceae	Others
Xanthohumol C is a prenylchalcone, that can be isolated from the hops of Humulus lupulus .

Isoxanthohumol 1 Publications Verification	Infection Flavonoids Classification of Application Fields Anti-aging Humulus lupulus L. Flavonones Source classification Plants Moraceae Disease Research Fields Cancer	HSV
Isoxanthohumol is a prenylflavonoid from hops and beer. Isoxanthohumol exhibits an antiproliferative activity against several human cancer cell lines. Isoxanthohumol inhibits the development of lung metastatic foci in tumor-challenged animals. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV) .

(2S)-Isoxanthohumol	Flavonoids Classification of Application Fields Humulus lupulus L. Flavonones Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields Cancer	Others
(2S)-Isoxanthohumol is a microbial biotransformed metabolite of the hop prenylflavanone Isoxanthohumol .

Hop-17(21)-en-3-ol (3β)-A'-Neogammacer-17(21)-en-3-ol	Triterpenes Structural Classification Gentiana scabra Bunge Terpenoids Source classification Gentianaceae Plants	Others
Hop-17(21)-en-3-ol ((3β)-A'-Neogammacer-17(21)-en-3-ol) is a Monoterpenoids product that can be isolated from the herbs of Xanthium sibiricum .

*3-Oxo-hop-22(29)-ene*	Cnidoscolus spinosus Lundell Triterpenes Terpenoids Source classification Euphorbiaceae Plants	Glucosidase
3-Oxo-hop-22(29)-ene is a yeast α-glucosidase inhibitor. 3-Oxo-hop-22(29)-ene shows a moderate effect on the viability of T. cruzi and L. mexicana. 3-Oxo-hop-22(29)-ene shows marginal activity of anti-inflammatory .

*3β-Hydroxy-hop-22(29)-ene*	Cnidoscolus spinosus Lundell Triterpenes Terpenoids Source classification Euphorbiaceae Plants	Parasite
3β-Hydroxy-hop-22(29)-ene (compound 3) is a potent antiparasitic agent. 3β-Hydroxy-hop-22(29)-ene shows moderate activity against Trypanosoma cruzi and Leishmania mexicana .

*3β-Acetoxy-hop-22(29)-ene*	Cnidoscolus spinosus Lundell Triterpenes Terpenoids Source classification Euphorbiaceae Plants	Glucosidase
3β-Acetoxy-hop-22(29)-ene (compound 1) is a potent anti-inflammatory agent. 3β-Acetoxy-hop-22(29)-ene shows high inhibitory activity of yeast α-glucosidase, with an IC₅₀ of 5.74 μM. 3β-Acetoxy-hop-22(29)-ene inhibits MPO (myeloperoxidase) activity in a dose-dependent manner in mouse ear edema model induced by 12-O-tetradecanoylphorbol acetate (TPA), with an IC₅₀ of 0.23 μmol/ear .

Hulupinic acid	Structural Classification Natural Products Humulus lupulus L. Source classification Plants Moraceae	Others
Hulupinic acid is a prominent oxidation product of hop acids .

Isoxanthohumol (Standard)	Flavonoids Humulus lupulus L. Flavonones Source classification Plants Moraceae	HSV
Isoxanthohumol (Standard) is the analytical standard of Isoxanthohumol. This product is intended for research and analytical applications. Isoxanthohumol is a prenylflavonoid from hops and beer. Isoxanthohumol exhibits an antiproliferative activity against several human cancer cell lines. Isoxanthohumol inhibits the development of lung metastatic foci in tumor-challenged animals. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV) .

Glochidone	Triterpenes Structural Classification Phyllanthaceae Terpenoids Source classification Glochidion wrightii Benth. Plants	Others
Glochidone is an anti-cancer agent with IC₅₀s of 5.52 μM and 7.84 μM against HOP-62 and EPLC-272H cells, respectively .

β-Acids colupulone	Structural Classification Natural Products Humulus lupulus L. Source classification Plants Moraceae	Others
β-Acids colupulone is the bitter substance. β-Acids colupulone can be isolated from hops .

Lupulone	Infection Classification of Application Fields Ketones, Aldehydes, Acids Humulus lupulus L. Source classification Plants Moraceae Disease Research Fields Cancer	Bacterial
Lupulone is a beta-acid from the hop plant H. lupulus with diverse biological activities including antibacterial, antioxidant, and anticarcinogenic properties .

Desmethylxanthohumol 1 Publications Verification	Structural Classification Chalcones Flavonoids Classification of Application Fields Humulus lupulus L. Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields Cancer	Apoptosis
Desmethylxanthohumol is a prenylated hydroxychalcone isolated from hop cones (Humulus lupulus L.). Desmethylxanthohumol is a powerful apoptosis inducing agent. Desmethylxanthohumol has antiplasmodial, antiproliferative, and antioxidant bioactivities .

2-(3-Hydroxy-2-oxoindolin-3-yl)-acetic acid	Alkaloids Structural Classification Humulus lupulus L. Source classification Plants Moraceae Indole Alkaloids	Others
2-(3-Hydroxy-2-oxoindolin-3-yl)-acetic acid (compound 29) is a natural polyphenol compound found in hop bract .

Xanthohumol D 1 Publications Verification	Structural Classification Chalcones Flavonoids Classification of Application Fields Humulus lupulus L. Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields Cancer	Others
Xanthohumol D, isolated from hops, is an inhibitor of quinone reductase-2 (QR-2) with the IC₅₀ value of 110 μM, and binds to the active site of QR-2. Xanthohumol D shows antiproliferative activity on human cancer cell lines in vitro .

Xanthohumol Maximum Cited Publications 8 Publications Verification	Infection Structural Classification Chalcones Flavonoids Classification of Application Fields Humulus lupulus L. Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields	COX Acyltransferase Apoptosis HSV CMV Influenza Virus
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).

8-Prenylnaringenin 1 Publications Verification	Flavonoids Classification of Application Fields Humulus lupulus L. Flavonones Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields Cancer	Apoptosis
8-prenylnaringenin is a prenylflavonoid isolated from hop cones Humulus lupulus, with cytotoxicity. 8-prenylnaringenin has anti-proliferative activity against HCT-116 colon cancer cells via induction of intrinsic and extrinsic pathway-mediated apoptosis. 8-Prenylnaringenin also promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice .

Xanthohumol (Standard)	Structural Classification Chalcones Flavonoids Humulus lupulus L. Source classification Phenols Polyphenols Plants Moraceae	COX Acyltransferase Apoptosis HSV CMV Influenza Virus
Xanthohumol (Standard) is the analytical standard of Xanthohumol. This product is intended for research and analytical applications. Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).

6,8-Diprenylnaringenin Lonchocarpol A; Senegalensin	Structural Classification Classification of Application Fields Erythrinasenegalensis DC. Source classification Metabolic Disease Plants Moraceae Flavonoids Leguminosae Humulus lupulus L. Flavonones Phenols Polyphenols Disease Research Fields Cancer	BCRP
6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and ³H-Methotrexate transport (IC₅₀=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80979

	HOPX Antibody CAMEO antibody; heart odd homeobox 1 protein antibody; HOD antibody; Homeodomain-only protein antibody; Hop antibody; Hop homeobox antibody; Hop_HUMAN antibody; HopX antibody; LAGY antibody; Lung cancer-associated Y protein antibody; NECC1 antibody; Not expressed in choriocarcinoma clone 1 antibody; Not expressed in choriocarcinoma protein 1 antibody; OB1 antibody; odd homeobox 1 protein antibody; Odd homeobox protein 1 antibody; OTTHUMP00000158970 antibody; SMAP31 antibody; TOTO antibody	WB, IP	Human
	HOPX Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 8 kDa, targeting to HOPX. It can be used for WB, IP assays with tag free, in the background of Human.

HY-P82335

	STIP1 Antibody (YA2080) Hop; P60; STI1; STI1L; STIP1; Stress induced phospHoprotein 1	WB, IHC-P, IP	Human, Mouse, Rat
	STIP1 Antibody (YA2080) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2080), targeting STIP1, with a predicted molecular weight of 63 kDa (observed band size: 63 kDa). STIP1 Antibody (YA2080) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.

HY-P81993

	Hsc70 Interacting Protein HIP Antibody (YA1738) HIP; Hop; P48; AAG2; SNC6; HSPABP; FAM10A1; FAM10A4; HSPABP1; ST13	WB, IHC-P, ICC/IF, FC	Human, Mouse
	Hsc70 Interacting Protein HIP Antibody (YA1738) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1738), targeting Hsc70 Interacting Protein HIP, with a predicted molecular weight of 41 kDa (observed band size: 47 kDa). Hsc70 Interacting Protein HIP Antibody (YA1738) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse background.

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Hop-17(21)-en-3-ol

Inhibitors & Agonists

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