6,8-Diprenylnaringenin (Synonyms: Lonchocarpol A; Senegalensin)

Cat. No.: HY-122416: FAQs
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6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and ³H-Methotrexate transport (IC₅₀=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin.

For research use only. We do not sell to patients.

6,8-Diprenylnaringenin Chemical Structure

CAS No. : 68236-11-3

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5 mg	Get quote	Estimated Time of Arrival: December 31
10 mg	Get quote	Estimated Time of Arrival: December 31
25 mg	Get quote	Estimated Time of Arrival: December 31

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
L1210	IC₅₀	> 10 μg/mL Compound: lonchocarpol A	Cytotoxicity against mouse L1210 cells by MTT assay Cytotoxicity against mouse L1210 cells by MTT assay	[PMID: 9599265]
L1210	IC₅₀	10 μg/mL Compound: lonchocarpol A	Cytotoxicity against mouse L1210 cells after 24 hrs by trypan blue assay Cytotoxicity against mouse L1210 cells after 24 hrs by trypan blue assay	[PMID: 9599265]

Molecular Weight

408.49

Formula

C₂₅H₂₈O₅

CAS No.

68236-11-3

SMILES

O=C1C[C@H](OC2=C(C(O)=C(C(O)=C12)C/C=C(C)\C)C/C=C(C)\C)C3=CC=C(C=C3)O

Structure Classification

Initial Source

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tan KW, et al. Hop-derived prenylflavonoids are substrates and inhibitors of the efflux transporter breast cancer resistance protein (BCRP/ABCG2). Mol Nutr Food Res. 2014 Nov;58(11):2099-110. [Content Brief]

[2]. Milligan SR, et al. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. J Clin Endocrinol Metab. 2000 Dec;85(12):4912-5. [Content Brief]

6,8-Diprenylnaringenin Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6,8-Diprenylnaringenin68236-11-3Lonchocarpol A SenegalensinBCRPBreast cancer resistance proteinABCG2cancerestrogenicityefflux of mitoxantronemethotrexate transportcellsInhibitorinhibitorinhibit

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