2. Membrane Transporter/Ion Channel
  3. BCRP
  4. 6,8-Diprenylnaringenin

6,8-Diprenylnaringenin  (Synonyms: Lonchocarpol A; Senegalensin)

Cat. No.: HY-122416
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6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and 3H-Methotrexate transport (IC50=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin.

For research use only. We do not sell to patients.

6,8-Diprenylnaringenin Chemical Structure

6,8-Diprenylnaringenin Chemical Structure

CAS No. : 68236-11-3

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6,8-Diprenylnaringenin Related Antibodies

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Description

6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and 3H-Methotrexate transport (IC50=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin[1][2].

Molecular Weight

408.49

Formula

C25H28O5
CAS No.
SMILES

O=C1C[C@H](OC2=C(C(O)=C(C(O)=C12)C/C=C(C)\C)C/C=C(C)\C)C3=CC=C(C=C3)O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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6,8-Diprenylnaringenin Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6,8-Diprenylnaringenin68236-11-3Lonchocarpol A SenegalensinBCRPBreast cancer resistance proteinABCG2cancerestrogenicityefflux of mitoxantronemethotrexate transportcellsInhibitorinhibitorinhibit

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