Hsp27

By Targets:	Antibiotic (1) Apoptosis (2) Bacterial (2) Deubiquitinase (1) Endogenous Metabolite (1) ERK (2) HSP (7) iGluR (3) JNK (2) LPL Receptor (1) MAPKAPK2 (MK2) (2) NF-κB (1) Nuclear Factor of activated T Cells (NFAT) (1) p38 MAPK (4) Phosphatase (2) Reactive Oxygen Species (1) SHP2 (2)
By Research Areas:	Cancer (9) Cardiovascular Disease (1) Infection (2) Metabolic Disease (1) Neurological Disease (3)
Oligonucleotides:	Antisense Oligonucleotides (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124653

HSP27 inhibitor J2 5 Publications Verification J2	HSP	Cancer
HSP27 inhibitor J2 (J2) is a *HSP27* inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition .

HY-145722

Apatorsen sodium OGX-427 sodium	HSP	Cancer
Apatorsen (sodium) is an antisense oligonucleotide designed to bind to Hsp27* mRNA, resulting in the inhibition* of the production of Hsp27 protein.

HY-P10072A

MK2-IN-5 acetate Hsp25 kinase inhibitor acetate; Mk2 pseudosubstrate acetate	JNK HSP MAPKAPK2 (MK2) p38 MAPK ERK	Others
MK2-IN-5 (Hsp25 kinase inhibitor) acetate is a Mk2 pseudosubstrate (K_i= 8 μM). MK2-IN-5 acetate targets the protein interaction domain in the MAPK pathway. MK2-IN-5 acetate inhibits HSP25 and HSP27 phosphorylation .

HY-N6712

Thiolutin 2 Publications Verification Acetopyrrothin	Bacterial Antibiotic Endogenous Metabolite Deubiquitinase	Infection Metabolic Disease
Thiolutin (Acetopyrrothin) is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Thiolutin inhibits the JAMM metalloproteases Csn5, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH) and Brcc36 . Thiolutin is a potent and selective inhibitor of endothelial cell adhesion accompanied by rapid induction of Heat-shock protein beta-1 (Hsp27) phosphorylation .

HY-18669

ML346 3 Publications Verification	HSP	Cancer
ML346 is an activator of Hsp70 expression and HSF-1 activity, with an EC₅₀ of 4.6 μM for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR), including chaperones such as Hsp70, Hsp40, and Hsp27 .

HY-18756

NSC-87877 1 Publications Verification	SHP2 Phosphatase Apoptosis	Others
NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC₅₀ values of 0.318 μM, 0.355 μM shp2 and shp1, respectively . NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26) .

HY-18756A

NSC-87877 disodium 1 Publications Verification	SHP2 Phosphatase Apoptosis	Cancer
NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC₅₀ values of 0.318 μM, 0.355 μM shp2 and shp1, respectively . NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26) .

HY-10406

Talmapimod 3 Publications Verification SCIO-469	p38 MAPK	Cancer
Talmapimod (SCIO-469) is an orally active, selective, and ATP-competitive p38α inhibitor with an IC₅₀ of 9 nM. Talmapimod shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs .

HY-145722A

Apatorsen OGX-427	HSP	Cancer
Apatorsen is an antisense oligonucleotide designed to bind to Hsp27* mRNA, resulting in the inhibition* of the production of Hsp27 protein.

HY-P10072

MK2-IN-5 Hsp25 kinase inhibitor; Mk2 pseudosubstrate	ERK JNK p38 MAPK HSP MAPKAPK2 (MK2)	Others
MK2-IN-5 is a Mk2 pseudosubstrate (K_i= 8 μM). MK2-IN-5 targets the protein interaction domain in the MAPK pathway. MK2-IN-5 inhibits HSP25 and HSP27 phosphorylation .

HY-10406A

Talmapimod hydrochloride SCIO-469 hydrochloride	p38 MAPK	Cancer
Talmapimod (SCIO-469) hydrochloride is an orally active, selective, and ATP-competitive p38α inhibitor with an IC₅₀ of 9 nM. Talmapimod hydrochloride shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs .

HY-108494

CYM50260	LPL Receptor	Cardiovascular Disease
CYM50260 is a potent and exquisitely selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonist with an EC₅₀ of 45 nM. CYM50260 displays no activity against S1P₁-R, S1P₂-R, S1P₃-R and S1P₅-R .

HY-B1126

Orphenadrine hydrochloride	iGluR	Neurological Disease
Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a K_i of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .

HY-138280

DTHIB 4 Publications Verification	HSP	Cancer
DTHIB is a direct and selective heat shock factor 1 (HSF1) inhibitor with a K_d of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD). DTHIB inhibits HSF1 cancer gene signature (HSF1 CaSig) and selectively stimulates degradation of nuclear HSF1. DTHIB has potently anticancer activities and can be used for prostate cancer research .

HY-B0369A

Orphenadrine citrate	iGluR	Neurological Disease
Orphenadrine citrate is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a K_i of 6.0 μM. Orphenadrine citrate relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine citrate is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .

HY-123922

NOSO-502	Bacterial	Infection
NOSO-502 is an inhibitor of bacterial translation. NOSO-502 exhibits inhibitory activity against Enterobacteriaceae. NOSO-502 has good safety and antibacterial properties .

HY-B0369AR

Orphenadrine citrate (Standard)	iGluR	Neurological Disease
Orphenadrine (citrate) (Standard) is the analytical standard of Orphenadrine (citrate). This product is intended for research and analytical applications. Orphenadrine citrate is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine citrate relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine citrate is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .

HY-117987

CPS-11 N-(Hydroxymethyl)thalidomide	Nuclear Factor of activated T Cells (NFAT) NF-κB Reactive Oxygen Species	Cancer
CPS-11 (N-(Hydroxymethyl)thalidomide) a Thalidomide (HY-14658) analogue, is a potent anti-cancer agent. CPS-11 inhibits NF-κB, activates NFAT, and repress cytokine expression through elevated ROS. CPS-11 exhibits a wider activity spectrum and higher potency against MM (multiple myeloma) cell lines .

Cat. No.	Product Name	Target	Research Area

HY-P10072A

MK2-IN-5 acetate Hsp25 kinase inhibitor acetate; Mk2 pseudosubstrate acetate	JNK HSP MAPKAPK2 (MK2) p38 MAPK ERK	Others
MK2-IN-5 (Hsp25 kinase inhibitor) acetate is a Mk2 pseudosubstrate (K_i= 8 μM). MK2-IN-5 acetate targets the protein interaction domain in the MAPK pathway. MK2-IN-5 acetate inhibits HSP25 and HSP27 phosphorylation .

HY-P10072

MK2-IN-5 Hsp25 kinase inhibitor; Mk2 pseudosubstrate	ERK JNK p38 MAPK HSP MAPKAPK2 (MK2)	Others
MK2-IN-5 is a Mk2 pseudosubstrate (K_i= 8 μM). MK2-IN-5 targets the protein interaction domain in the MAPK pathway. MK2-IN-5 inhibits HSP25 and HSP27 phosphorylation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6712

Thiolutin 2 Publications Verification Acetopyrrothin	Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Metabolic Disease Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Antibiotic Endogenous Metabolite Deubiquitinase
Thiolutin (Acetopyrrothin) is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Thiolutin inhibits the JAMM metalloproteases Csn5, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH) and Brcc36 . Thiolutin is a potent and selective inhibitor of endothelial cell adhesion accompanied by rapid induction of Heat-shock protein beta-1 (Hsp27) phosphorylation .

Cat. No.	Compare	Product Name	Species	Source

HY-P74878

	HSP27/HSPB1 Protein, Human (His) Heat shock protein beta-1; HspB1; Hsp 27; SRP27; HspB1; Hsp28	Human	E. coli
	The HSP27/HSPB1 protein is a small heat shock protein that acts as a molecular chaperone, possibly maintaining denatured proteins in a foldable state. In addition to its chaperone role, it crucially enhances stress resistance and contributes to actin organization. HSP27/HSPB1 Protein, Human (His) is the recombinant human-derived HSP27/HSPB1 protein, expressed by E. coli , with C-His labeled tag. The total length of HSP27/HSPB1 Protein, Human (His) is 205 a.a., with molecular weight of ~28 kDa.

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Species
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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80709

	Hsp27 Antibody (YA732) HspB1; Hsp27; Hsp28; Heat shock protein beta-1; HspB1; 28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; Hsp 27; Stress-responsive protein 27; SRP27	WB, ICC/IF	Human, Monkey
	Hsp27 Antibody (YA732) is a non-conjugated and Mouse origined monoclonal antibody about 23 kDa, targeting to Hsp27 (7E5). It can be used for WB,ICC/IF assays with tag free, in the background of Human, Monkey.

HY-P80823

	*Phospho-Hsp27* (Ser78) Antibody** HspB1; Hsp27; Hsp28; Heat shock protein beta-1; HspB1; 28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; Hsp 27; Stress-responsive protein 27; SRP27	WB, IHC-P, ICC/IF	Human
	Phospho-Hsp27 (Ser78) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 23 kDa, targeting to Phospho-Hsp27 (Ser78). It can be used for WB,IHC-P,ICC/IF assays with tag free, in the background of Human.

HY-P80824

	*Phospho-Hsp27* (Ser82) Antibody** HspB1; Hsp27; Hsp28; Heat shock protein beta-1; HspB1; 28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; Hsp 27; Stress-responsive protein 27; SRP27	WB, IHC-P	Human
	Phospho-Hsp27 (Ser82) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 23 kDa, targeting to Phospho-Hsp27 (Ser82). It can be used for WB,IHC-P assays with tag free, in the background of Human.

HY-P80465

	*Phospho-Hsp27* (Ser82) Antibody (YA187)**	WB, IP	Human
	Phospho-Hsp27 (Ser82) Antibody (YA187) is a non-conjugated and Rabbit origined monoclonal antibody about 23 kDa, targeting to Phospho-Hsp27(S82). It can be used for WB,IP assays with tag free, in the background of Human.

HY-P81306

	SAFB1 Antibody (YA1042) SAFB; HAP; HET; SAFB1; Scaffold attachment factor B1; SAF-B; SAF-B1; Hsp27 estrogen response element-TATA box-binding protein; Hsp27 ERE-TATA-binding protein	WB, ICC/IF, ChIP	Human
	SAFB1 Antibody (YA1042) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA1042), targeting SAFB1, with a predicted molecular weight of 103 kDa (observed band size: 130 kDa). SAFB1 Antibody (YA1042) can be used for WB, ICC/IF, ChIP experiment in human background.

HY-P81306A

	SAFB1 Antibody (YA1043) SAFB; HAP; HET; SAFB1; Scaffold attachment factor B1; SAF-B; SAF-B1; Hsp27 estrogen response element-TATA box-binding protein; Hsp27 ERE-TATA-binding protein	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse
	SAFB1 Antibody (YA1043) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1043), targeting SAFB1, with a predicted molecular weight of 103 kDa (observed band size: 150 kDa). SAFB1 Antibody (YA1043) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human, mouse background.

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Free Sample	Yes No
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Cat. No.	Product Name		Classification

HY-145722

Apatorsen sodium OGX-427 sodium		Antisense Oligonucleotides
Apatorsen (sodium) is an antisense oligonucleotide designed to bind to Hsp27* mRNA, resulting in the inhibition* of the production of Hsp27 protein.

HY-145722A

Apatorsen OGX-427		Antisense Oligonucleotides
Apatorsen is an antisense oligonucleotide designed to bind to Hsp27* mRNA, resulting in the inhibition* of the production of Hsp27 protein.

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