SAFB1 Antibody (YA1042)

SAFB1 Antibody (YA1042) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA1042), targeting SAFB1, with a predicted molecular weight of 103 kDa (observed band size: 130 kDa). SAFB1 Antibody (YA1042) can be used for WB, ICC/IF, ChIP experiment in human background.

The related gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). The protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether The protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed related genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorirelated genesis. The related gene is arranged head-to-head with a similar related gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for The related gene.

6294

Predicted band size: 103 kDa; Observed band size: 130 kDa

Affinity Purified

Non-conjugated

Unmodified

Epigenetics and Nuclear Signaling

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

Q15424

WB: 1/500-1/1000;IF: 1/50-1/200;ChIP: 1/20

WB, ICC/IF, ChIP

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Endogenous

Purified recombinant human SAFB1 protein fragments expressed in E.coli.