NSC-87877 disodium

Name: NSC-87877 disodium
Brand: MedChemExpress
SKU: HY-18756A
Rating: 4.5 (1 reviews)

Cat. No.: HY-18756A Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC₅₀ values of 0.318 μM, 0.355 μM shp2 and shp1, respectively. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26).

For research use only. We do not sell to patients.

NSC-87877 disodium Chemical Structure

CAS No. : 56932-43-5

Size	Price	Stock	Quantity
5 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
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200 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of NSC-87877 disodium:

NSC-87877 Get quote

1 Publications Citing Use of MCE NSC-87877 disodium

•Neural Regen Res. 2025 Mar 1;20(3):858-872. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC₅₀ values of 0.318 μM, 0.355 μM shp2 and shp1, respectively^[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)^[2].

IC₅₀ & Target

IC50: 0.318 μM (shp2), 0.355 μM (shp1)^[1].

In Vitro

NSC-87877 (0-0.5 μM, 5 days) inhibits DUSP26 function in NB cell lines^[3].
NSC-87877 (0-0.5 μM, 5 days) results in increased p53 phosphorylation (Ser37 and Ser46) and activation^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	p53 wild-type neuroblastoma (NB) cell lines.
Concentration:	0, 0.25, 0.5 μM.
Incubation Time:	5 days.
Result:	Resulted in increased p53 phosphorylation (Ser37 and Ser46) and activation, increased activation of downstream p38 effector proteins (heat shock protein 27 (HSP27) and MAP kinase-activated protein kinase 2 (MAPKAPK2)) and poly ADP ribose polymerase/caspase-3 cleavage. Inhibited DUSP26 function in NB cell lines. Resulted in apoptosis in many cell lines at varying IC₅₀ levels of 1.84 μM (IMR32), 6.35 μM (SK-N-SH), 8.69 μM (NB-19), 12.6 μM (SMS-KCN), 15.7 μM (SH-SY5Y), 15.8 μM (JF) and 19.0 μM (CHLA-225), respectively.

In Vivo

NSC-87877 (30?mg/kg, IP once daily for 15 days) possesses excellent anti- neuroblastoma activity^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Intrarenal neuroblastoma (NB) tumor mouse model in female nude mice^[3].
Dosage:	30 mg/kg.
Administration:	IP once daily for 15 days.
Result:	Significantly inhibited NB tumor growth.

Molecular Weight

503.42

Formula

C₁₉H₁₁N₃Na₂O₇S₂

CAS No.

56932-43-5

Appearance

Solid

Color

Brown to black

SMILES

O=S(C1=C2C=CC=NC2=C(O)C(/N=N/C3=CC=C4C=C(S(=O)(O[Na])=O)C=CC4=C3)=C1)(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (248.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 50 mg/mL (99.32 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9864 mL	9.9321 mL	19.8641 mL
5 mM	0.3973 mL	1.9864 mL	3.9728 mL
10 mM	0.1986 mL	0.9932 mL	1.9864 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (251 KB) HNMR (288 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. Chen L, et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70(2):562-70. [Content Brief]

[2]. Song M, et al. NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochem Biophys Res Commun. 2009 Apr 17;381(4):491-5. [Content Brief]

[3]. Y Shi, et al. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015 Aug 6;6(8):e1841. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.9864 mL	9.9321 mL	19.8641 mL	49.6603 mL
	5 mM	0.3973 mL	1.9864 mL	3.9728 mL	9.9321 mL
	10 mM	0.1986 mL	0.9932 mL	1.9864 mL	4.9660 mL
	15 mM	0.1324 mL	0.6621 mL	1.3243 mL	3.3107 mL
	20 mM	0.0993 mL	0.4966 mL	0.9932 mL	2.4830 mL
	25 mM	0.0795 mL	0.3973 mL	0.7946 mL	1.9864 mL
	30 mM	0.0662 mL	0.3311 mL	0.6621 mL	1.6553 mL
	40 mM	0.0497 mL	0.2483 mL	0.4966 mL	1.2415 mL
	50 mM	0.0397 mL	0.1986 mL	0.3973 mL	0.9932 mL
	60 mM	0.0331 mL	0.1655 mL	0.3311 mL	0.8277 mL
	80 mM	0.0248 mL	0.1242 mL	0.2483 mL	0.6208 mL
DMSO	100 mM	0.0199 mL	0.0993 mL	0.1986 mL	0.4966 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.