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By Targets:	CD28 (1)
By Research Areas:	Inflammation/Immunology (1)

ICOS-IN-1	CD28	Others
ICOS-IN-1 (compound 9) is an inhibitor of the interaction between ICOS and *ICOS-L* (IC₅₀=29.38 μM) and has activity in recognizing immune checkpoints .

Prezalumab AMG 557	Inhibitory Antibodies	Inflammation/Immunology
Prezalumab (AMG 557) is a monoclonal antibody targeting ICOSL that has synergistic anti-inflammatory activity with CD28 antibody inhibitors .

*Anti-Mouse ICOSL/CD275 Antibody (HK5.3)*	Inhibitory Antibodies	Others
Anti-Mouse ICOSL/CD275 Antibody (HK5.3) is a rat-derived IgG2a, κ type antibody inhibitor, targeting to mouse ICOSL/CD275.

*Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3)*	Inhibitory Antibodies	Others
Anti-Mouse ICOSL/CD275 (LALA-PG) Antibody (HK5.3) is a mouse-derived IgG2a, κ type antibody inhibitor, targeting to mouse ICOSL/CD275.

*Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3)*	Inhibitory Antibodies	Others
Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to mouse ICOSL/CD275.

Rozibafusp alfa AMG-570	Inhibitory Antibodies	Others
Rozibafusp alfa (AMG-570) is a humanized IgG2-κ monoclonal antibody targets *ICOSL* and BAFF. Prezalumab demonstrates beneficial activities on the arthritis of systemic lupus erythematosus. Prezalumab can be used for the research of sjogren's syndrome cutaneous lupus erythematosus, psoriasis and systemic lupus erythematosus (SLE) .

Species:	Human (2) Mouse (2) Rat (2) Cynomolgus (2)
Tag:	His (6) Avi (2) Fc (3)
Source:	HEK293 (8)

Cat. No.	Compare	Product Name	Species	Source

HY-P78075

	B7-H2/ICOSLG Protein, Human (Biotinylated, HEK293, His-Avi) CD275; B7H2; B7-H2; B7RP-1; GL50; ICOSL; ICOS-L; ICOSLG; B7RP1; LICOS; ICOS ligand; B7-H2B7-related protein 1; B7RP-1; B7RP1B7-like protein Gl50	Human	HEK293
	B7-H2/ICOSLG Protein, a ligand for T-cell receptor ICOS, critically costimulates T-cell proliferation and cytokine secretion. It induces B-cell proliferation and supports plasma cell differentiation, playing a key role in local tissue responses to inflammation. B7-H2/ICOSLG also modulates the secondary immune response by co-stimulating memory T-cell function. In molecular interactions, it has been observed to interact with CTLA4 in vitro. B7-H2/ICOSLG Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P73120

	B7-H2/ICOSLG Protein, Mouse (HEK293, His) ICOS ligand; B7-H2; ICOSLG; LICOS; B7RP-1; CD275	Mouse	HEK293
	B7-H2/ICOSLG, a crucial ligand for T-cell receptor ICOS, mediates immune responses. It serves as a costimulatory signal, promoting T-cell and B-cell proliferation, cytokine secretion, and plasma cell differentiation. Beyond immune activation, it may influence local tissue responses during inflammation and modulate secondary immune responses. During pregnancy, B7-H2/ICOSLG favors an immunoprotective Th2 phenotype in maternal T-cells. It also interacts with CTLA4, contributing to intricate regulatory pathways of immune function. B7-H2/ICOSLG Protein, Mouse (HEK293, His) is the recombinant mouse-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-His labeled tag. The total length of B7-H2/ICOSLG Protein, Mouse (HEK293, His) is 233 a.a., with molecular weight of ~40-52 kDa.

HY-P75486

	B7-H2/ICOSLG Protein, Rat (HEK293, His) ICOS ligand; B7-H2; ICOSLG; LICOS; B7RP-1; CD275	Rat	HEK293
	B7-H2/ICOSLG Protein, a ligand for T-cell receptor ICOS, critically costimulates T-cell proliferation and cytokine secretion. It induces B-cell proliferation and supports plasma cell differentiation, playing a key role in local tissue responses to inflammation. B7-H2/ICOSLG also modulates the secondary immune response by co-stimulating memory T-cell function. In molecular interactions, it has been observed to interact with CTLA4 in vitro. B7-H2/ICOSLG Protein, Rat (HEK293, His) is the recombinant rat-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-His labeled tag.

HY-P76393

	B7-H2/ICOSLG Protein, Cynomolgus (HEK293, His) ICOS ligand; B7-H2; ICOSLG; LICOS; B7RP-1; CD275	Cynomolgus	HEK293
	The Angiopoietin-1 Protein is a secreted glycoprotein that is a key ligand in the vascular tyrosine kinase signaling pathway. ANGPT1 stimulates angiogenesis by activating PTK2/FAK and downstream kinase MAPK1/ERK2 and MAPK3/ERK1 signaling pathways. ANGPT1 affects the proliferation, migration and differentiation of skeletal muscle cells. B7-H2/ICOSLG Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-His labeled tag. The total length of B7-H2/ICOSLG Protein, Cynomolgus (HEK293, His) is 256 a.a., with molecular weight of 50-70 KDa.

HY-P78392

	B7-H2/ICOSLG Protein, Human (HEK293, His-Avi) CD275; B7H2; B7-H2; B7RP-1; GL50; ICOSL; ICOS-L; ICOSLG; B7RP1; LICOS; ICOS ligand; B7-H2B7-related protein 1; B7RP-1; B7RP1B7-like protein Gl50	Human	HEK293
	B7-H2/ICOSLG Protein, a ligand for T-cell receptor ICOS, critically costimulates T-cell proliferation and cytokine secretion. It induces B-cell proliferation and supports plasma cell differentiation, playing a key role in local tissue responses to inflammation. B7-H2/ICOSLG also modulates the secondary immune response by co-stimulating memory T-cell function. In molecular interactions, it has been observed to interact with CTLA4 in vitro. B7-H2/ICOSLG Protein, Human (HEK293, His-Avi) is the recombinant human-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P73119

	B7-H2/ICOSLG Protein, Mouse (HEK293, His-Fc) ICOS ligand; B7-H2; ICOSLG; LICOS; B7RP-1; CD275	Mouse	HEK293
	B7-H2/ICOSLG is an important ligand of the T cell receptor ICOS and mediates immune responses. It acts as a costimulatory signal, promoting T and B cell proliferation, cytokine secretion, and plasma cell differentiation. B7-H2/ICOSLG Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

HY-P75487

	B7-H2/ICOSLG Protein, Rat (HEK293, Fc) ICOS ligand; B7-H2; ICOSLG; LICOS; B7RP-1; CD275	Rat	HEK293
	B7-H2/ICOSLG Protein, a ligand for T-cell receptor ICOS, critically costimulates T-cell proliferation and cytokine secretion. It induces B-cell proliferation and supports plasma cell differentiation, playing a key role in local tissue responses to inflammation. B7-H2/ICOSLG also modulates the secondary immune response by co-stimulating memory T-cell function. In molecular interactions, it has been observed to interact with CTLA4 in vitro. B7-H2/ICOSLG Protein, Rat (HEK293, Fc) is the recombinant rat-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P76394

	B7-H2/ICOSLG Protein, Cynomolgus (HEK293, Fc) ICOS ligand; B7-H2; ICOSLG; LICOS; B7RP-1; CD275	Cynomolgus	HEK293
	B7-H2 is the ligand of Inducible Costimulator, was a ligand for CD28 and CTLA-4 in human, whereas these interactions were not conserved in mouse. B7-H2 interacted with CD28 in a non-overlapping domain. B7-H2 costimulation via CD28 induced survival factor Bcl-xL, downregulated cell cycle inhibitor p27^kip1 and triggered signaling cascade of ERK and AKT kinases-dependent pathways. B7-H2/ICOSLG Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-hFc labeled tag. The total length of B7-H2/ICOSLG Protein, Cynomolgus (HEK293, Fc) is 256 a.a., with molecular weight of ~53.3 KDa.

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