2. Inhibitory Antibodies
  3. Prezalumab

Prezalumab  (Synonyms: AMG 557)

Cat. No.: HY-P99414 Purity: 99.23%
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Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targets ICOSL and BAFF. Prezalumab demonstrates beneficial activities on the arthritis of systemic lupus erythematosus. Prezalumab can be used for the research of sjogren's syndrome cutaneous lupus erythematosus, psoriasis and systemic lupus erythematosus (SLE).

For research use only. We do not sell to patients.

CAS No. : 1523164-68-2

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Prezalumab Related Antibodies

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Description

Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targets ICOSL and BAFF. Prezalumab demonstrates beneficial activities on the arthritis of systemic lupus erythematosus. Prezalumab can be used for the research of sjogren's syndrome cutaneous lupus erythematosus, psoriasis and systemic lupus erythematosus (SLE)[1].

Isotype

Human IgG2 kappa
Recommend Isotype Controls
Species

Human
In Vivo

Prezalumab shows more efficacious effects than single ICOSL or BAFF inhibitor in mouse NZB/NZW lupus model and collagen induced arthritis (CIA) models[1].
Prezalumab reduces B cell in cynomolgus monkeys, same as the pharmacological effect of BAFF inhibition[1].
1.19 Pharmacokinetic Properties of Prezalumab in Cynomolgus Monkeys[1].

Cynomolgus Monkeys
IV 10 mg/kg		 Cynomolgus Monkeys
SC 10 mg/kg
Cmax (μg/mL) 264 112
Tmax (hr) 72
AUC0-inf (μg•hr/mL) 26100 23800
MRT0-inf (hr) 138 144
CL (mL/hr/kg) 0.388 0.427
Vss (mL/kg) 52.1

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Prezalumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG2 kappa
Purity & Documentation

Purity: 99.23%

COA (231 KB) SDS-PAGE (137 KB) SEC-HPLC (116 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Prezalumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Prezalumab1523164-68-2AMG 557AMG557AMG-557Othersmonoclonal antibodySLEpsoriasiscynomolgus monkeysCIAmiceInhibitorinhibitorinhibit

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