B7-H2/ICOSLG Protein, Mouse (HEK293, His-Fc)

B7-H2/ICOSLG is an important ligand of the T cell receptor ICOS and mediates immune responses. It acts as a costimulatory signal, promoting T and B cell proliferation, cytokine secretion, and plasma cell differentiation. B7-H2/ICOSLG Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

B7-H2/ICOSLG, a ligand for the T-cell-specific surface receptor ICOS, serves as a crucial mediator of immune responses. This protein functions as a costimulatory signal, promoting T-cell proliferation and cytokine secretion while also inducing B-cell proliferation and differentiation into plasma cells. Beyond its role in immune activation, B7-H2/ICOSLG may play a pivotal role in mediating local tissue responses during inflammatory conditions. Furthermore, it contributes to the modulation of the secondary immune response by co-stimulating memory T-cell function. Notably, during pregnancy, B7-H2/ICOSLG may influence the cytokine profile of maternal T-cells, favoring an immunoprotective Th2 phenotype. Additionally, the interaction of B7-H2/ICOSLG with CTLA4 has been observed in vitro, highlighting its involvement in intricate regulatory pathways of immune function.

Mouse

HEK293

C-hFc;C-His

Q9JHJ8-1 (E47-K279)

50723  [NCBI]

75-85 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.