2. Inhibitory Antibodies
  3. Rozibafusp alfa

Rozibafusp alfa  (Synonyms: AMG-570)

Cat. No.: HY-P99893

Molarity Calculator

Rozibafusp alfa (AMG-570) is a humanized IgG2-κ monoclonal antibody targets ICOSL and BAFF. Prezalumab demonstrates beneficial activities on the arthritis of systemic lupus erythematosus. Prezalumab can be used for the research of sjogren's syndrome cutaneous lupus erythematosus, psoriasis and systemic lupus erythematosus (SLE).

For research use only. We do not sell to patients.

CAS No. : 2143449-47-0

Size Stock
1 mg   Get quote  
5 mg   Get quote  
10 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Rozibafusp alfa Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Rozibafusp alfa (AMG-570) is a humanized IgG2-κ monoclonal antibody targets ICOSL and BAFF. Prezalumab demonstrates beneficial activities on the arthritis of systemic lupus erythematosus. Prezalumab can be used for the research of sjogren's syndrome cutaneous lupus erythematosus, psoriasis and systemic lupus erythematosus (SLE)[1][2].

Isotype

Human IgG2 kappa
Recommend Isotype Controls
Species

Fusion Protein
In Vivo

Rozibafusp alfa shows more efficacious effects than single ICOSL or BAFF inhibitor in mouse NZB/NZW lupus model and collagen induced arthritis (CIA) models[1].
Rozibafusp alfa reduces B cell in cynomolgus monkeys, same as the pharmacological effect of BAFF inhibition[1].
1.19 Pharmacokinetic Properties of Rozibafusp alfa in Cynomolgus Monkeys[1].

Cynomolgus Monkeys
IV 10 mg/kg		 Cynomolgus Monkeys
SC 10 mg/kg
Cmax (μg/mL) 264 112
Tmax (hr) 72
AUC0-inf (μg•hr/mL) 26100 23800
MRT0-inf (hr) 138 144
CL (mL/hr/kg) 0.388 0.427
Vss (mL/kg) 52.1

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
CAS No.
SMILES

[Rozibafusp alfa]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG2 kappa
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Rozibafusp alfa Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rozibafusp alfa2143449-47-0AMG-570AMG570AMG 570Othersmonoclonal antibodyIgG2-κInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Rozibafusp alfa
Cat. No.:
HY-P99893
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.