2. Inhibitory Antibodies
  3. Rozibafusp alfa

Rozibafusp alfa  (Synonyms: AMG-570)

Cat. No.: HY-P99893

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Rozibafusp alfa (AMG-570) is a humanized IgG2-κ monoclonal antibody targets ICOSL and BAFF. Prezalumab demonstrates beneficial activities on the arthritis of systemic lupus erythematosus. Prezalumab can be used for the research of sjogren's syndrome cutaneous lupus erythematosus, psoriasis and systemic lupus erythematosus (SLE).

For research use only. We do not sell to patients.

CAS No. : 2143449-47-0

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Rozibafusp alfa Related Antibodies

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Description

Rozibafusp alfa (AMG-570) is a humanized IgG2-κ monoclonal antibody targets ICOSL and BAFF. Prezalumab demonstrates beneficial activities on the arthritis of systemic lupus erythematosus. Prezalumab can be used for the research of sjogren's syndrome cutaneous lupus erythematosus, psoriasis and systemic lupus erythematosus (SLE)[1][2].

Isotype

Human IgG2 kappa
Recommend Isotype Controls
Species

Fusion Protein
In Vivo

Rozibafusp alfa shows more efficacious effects than single ICOSL or BAFF inhibitor in mouse NZB/NZW lupus model and collagen induced arthritis (CIA) models[1].
Rozibafusp alfa reduces B cell in cynomolgus monkeys, same as the pharmacological effect of BAFF inhibition[1].
1.19 Pharmacokinetic Properties of Rozibafusp alfa in Cynomolgus Monkeys[1].

Cynomolgus Monkeys
IV 10 mg/kg		 Cynomolgus Monkeys
SC 10 mg/kg
Cmax (μg/mL) 264 112
Tmax (hr) 72
AUC0-inf (μg•hr/mL) 26100 23800
MRT0-inf (hr) 138 144
CL (mL/hr/kg) 0.388 0.427
Vss (mL/kg) 52.1

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
CAS No.
SMILES

[Rozibafusp alfa]
Storage

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Format
  • Human IgG2 kappa
Purity & Documentation
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Rozibafusp alfa Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rozibafusp alfa2143449-47-0AMG-570AMG570AMG 570Othersmonoclonal antibodyIgG2-κInhibitorinhibitorinhibit

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