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J774 macrophages

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (2) Antibiotic (2) Drug Metabolite (3) Farnesyl Transferase (1) Isocitrate Dehydrogenase (IDH) (1) NOD-like Receptor (NLR) (1) Parasite (2)
By Research Areas:	Cancer (1) Endocrinology (2) Infection (2) Inflammation/Immunology (1) Metabolic Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Targets Recommended: Macrophage migration inhibitory factor (MIF)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-131521

Oxalomalic acid trisodium Oxalomalate trisodium	Isocitrate Dehydrogenase (IDH)	Cancer
Oxalomalic acid (Oxalomalate) trisodium is a aconitase and NADP-dependent isocitrate dehydrogenase inhibitor. Oxalomalic acid trisodium inhibits nitrite production and iNOS protein expression in lipopolysaccharide (HY-D1056)-activated J774 macrophages .

HY-129959

Aluminum phthalocyanine chloride AlClPc	Parasite	Infection
Aluminum phthalocyanine chloride is a photosensitizer that effectively inhibits the parasite Leishmania amazonensis (the causative agent of cutaneous leishmaniasis) by light-mediated cytolysis. Aluminum phthalocyanine chloride causes parasite morphology and cytolysis of isolated amasilians, while higher photosensitizer concentrations and light intensities are required to induce lysis of mammalian cells. Aluminum phthalocyanine chloride lyses parasites within infected J774 macrophages and can be used to further investigate the study of leishmaniasis .

HY-117432

JC-171	NOD-like Receptor (NLR)	Inflammation/Immunology
JC-171 is a selective NLRP3 inflammasome inhibitor, with an IC₅₀ of 8.45 μM for inhibiting LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages .

HY-B0802A

Terbutaline	Drug Metabolite Adrenergic Receptor Antibiotic	Endocrinology
Terbutaline is an orally active β₂-adrenergic receptor agonist and an active metabolite of bambuterol . Terbutaline can be used in asthma symptom research .

HY-B0802

Terbutaline sulfate Terbutaline hemisulfate	Adrenergic Receptor Antibiotic	Endocrinology
Terbutaline sulfate is an orally active β₂-adrenergic receptor agonist and an active metabolite of bambuterol . Terbutaline sulfate can be used in asthma symptom research .

HY-126489

Tetromycin B	Parasite	Infection
Tetromycin B is a cysteine protease inhibitor with Ki values of 0.62, 1.42, 32.5, and 1.59 μM for rhodesain, falcipain-2, cathepsin L, and cathepsin B, respectively. It inhibits the growth of T. brucei in vitro (IC₅₀=30.87 μM). Tetromycin B is also cytotoxic to HEK293T kidney cells and J774.1 macrophages (IC₅₀s=71.77 and 20.2 μM, respectively).

HY-B2097

Incadronate disodium YM 175; Bisphonal	Farnesyl Transferase	Metabolic Disease
Incadronate disodium (YM 175) is a bisphosphonate with strong inhibitory activity on bone resorption. Incadronate disodium indirectly stimulates renal 25-hydroxyvitamin D-1-hydroxylase by increasing circulating parathyroid hormone. Incadronate disodium, a cholesterol-lowering agent, is a potent inhibitor of rat liver microsomal squalene synthase (K_i=57 nM). Incadronate disodium inhibits sterol biosynthesis in mouse macrophage J774 cells (IC₅₀=64 μM). Incadronate disodium has the potential for malignant tumors research .

HY-137575

Terbutalone	Drug Metabolite	Others
Terbutalone is a derivative of Terbutaline (HY-B0802A). Terbutaline is an orally active β₂-adrenergic receptor agonist and an active metabolite of Bambuterol (HY-17501). Terbutaline can be used in asthma symptom research .

HY-137575R

Terbutalone (Standard)	Drug Metabolite	Others
Terbutalone (Standard) is the analytical standard of Terbutalone. This product is intended for research and analytical applications. Terbutalone is a derivative of Terbutaline (HY-B0802A). Terbutaline is an orally active β2-adrenergic receptor agonist and an active metabolite of Bambuterol (HY-17501). Terbutaline can be used in asthma symptom research .

HY-111248

ABD-295	Others	Others
ABD-295, a biphenylsulfide derivative, is an antiresorptive agent, osteoclast inhibitor. ABD-295 has potent inhibitory effects on osteoclastic bone resorption in vitro. ABD-295 prevents ovariectomy-induced bone loss in vivo ^{[1] ^.}

Cat. No.	Product Name	Type

HY-129959

Aluminum phthalocyanine chloride AlClPc	Dyes
Aluminum phthalocyanine chloride is a photosensitizer that effectively inhibits the parasite Leishmania amazonensis (the causative agent of cutaneous leishmaniasis) by light-mediated cytolysis. Aluminum phthalocyanine chloride causes parasite morphology and cytolysis of isolated amasilians, while higher photosensitizer concentrations and light intensities are required to induce lysis of mammalian cells. Aluminum phthalocyanine chloride lyses parasites within infected J774 macrophages and can be used to further investigate the study of leishmaniasis .

Aluminum phthalocyanine chloride

AlClPc

Dyes

Aluminum phthalocyanine chloride is a photosensitizer that effectively inhibits the parasite Leishmania amazonensis (the causative agent of cutaneous leishmaniasis) by light-mediated cytolysis. Aluminum phthalocyanine chloride causes parasite morphology and cytolysis of isolated amasilians, while higher photosensitizer concentrations and light intensities are required to induce lysis of mammalian cells. Aluminum phthalocyanine chloride lyses parasites within infected J774 macrophages and can be used to further investigate the study of leishmaniasis .

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