2. Metabolic Enzyme/Protease
  3. Isocitrate Dehydrogenase (IDH)
  4. Oxalomalic acid trisodium

Oxalomalic acid trisodium  (Synonyms: Oxalomalate trisodium)

Cat. No.: HY-131521 Purity: ≥95.0%
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Oxalomalic acid (Oxalomalate) trisodium is a aconitase and NADP-dependent isocitrate dehydrogenase inhibitor. Oxalomalic acid trisodium inhibits nitrite production and iNOS protein expression in lipopolysaccharide (HY-D1056)-activated J774 macrophages.

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Oxalomalic acid trisodium Chemical Structure

Oxalomalic acid trisodium Chemical Structure

CAS No. : 89304-26-7

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Based on 1 publication(s) in Google Scholar

Oxalomalic acid trisodium Related Antibodies

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Description

Oxalomalic acid (Oxalomalate) trisodium is a aconitase and NADP-dependent isocitrate dehydrogenase inhibitor. Oxalomalic acid trisodium inhibits nitrite production and iNOS protein expression in lipopolysaccharide (HY-D1056)-activated J774 macrophages[1].

In Vitro

Oxalomalic acid trisodium (2.2, 5 mM; 2+24 h) reduces LPS-induced nitrite production and iNOS protein expression in J774 cells[1].
Oxalomalic acid trisodium (5 mM; 6, 12 h) shows no effect on the expression of iNOS mRNA in LPS-stimulated J774 macrophages[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Oxalomalic acid trisodium Related Antibodies

Western Blot Analysis[1]

Cell Line: J774 cells
Concentration: 2.2, 5 mM (stimulated with LPS (1 μg/ml))
Incubation Time: 2+24 h
Result: Reduced in a significant and concentration-dependent manner nitrite production, reduced iNOS protein expression.
Molecular Weight

272.05

Formula

C6H3Na3O8
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C(C(C(C(O[Na])=O)O)C(O[Na])=O)=O)O[Na]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 1 mg/mL (3.68 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6758 mL 18.3790 mL 36.7579 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥95.0%

COA (251 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.6758 mL 18.3790 mL 36.7580 mL 91.8949 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Oxalomalic acid trisodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxalomalic acid trisodium89304-26-7Oxalomalate trisodiumIsocitrate Dehydrogenase (IDH)LPSnitriteiNOS proteinJ774 cellsInhibitorinhibitorinhibit

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