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Results for "

Kv7.2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cytochrome P450 (2) Potassium Channel (12)
By Research Areas:	Cancer (1) Neurological Disease (11)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

ML213	Potassium Channel	Neurological Disease
ML213 is a selective activator of *Kv7.2* and *Kv7.4* channels, enhances Kv7.2 and Kv7.4 channels with EC₅₀s of 230 and 510 nM, respectively.

XE991 dihydrochloride 3 Publications Verification	Potassium Channel	Neurological Disease
XE991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC₅₀s of 0.75 µM, 0.71 µM, 0.6 μM, and 0.98 µM, respectively .

ML252	Potassium Channel Cytochrome P450	Neurological Disease
ML252 is a selective inhibitor of KCNQ2 (Kv7.2) channel with an IC₅₀s of 69 nM, 2.92 μM, 0.12 μM and 0.20 μM for KCNQ2, KCNQ1 (Kv7.1), KCNQ2/Q3 and KCNQ4, respectively. ML252 also inhibits Cytochrome P450 with IC₅₀s of 6.1 nM (CYP1A2), 18.9 nM (CYP2C9), 3.9 nM (CYP3A4), 19.9 nM (CYP2D6), respectively. ML252 shows highly brain penetrant .

ICA 110381	Potassium Channel	Neurological Disease
ICA 110381 is an orally active *Kv7.2/Kv7.3* (KCNQ2/3) potassium channel activator with anticonvulsive properties. ICA 110381 is a KCNQ2/Q3 activator (EC₅₀=0.38 μM) as well as KCNQ1 antagonist (IC₅₀=15 μM) .

Azetukalner XEN1101	Potassium Channel	Cancer
KCNQ2/3 activator-1 is an activator of *Kv7.2/Kv7.3* (KCNQ2/3) potassium channel. KCNQ2/3 activator-1 has the potential in relieving pain (the main problem from medical treatment) (extracted from patent WO2021113757A1, compound A) .

Kv7.2 modulator 1	Potassium Channel	Neurological Disease
Kv7.2 modulator 1 (compound 10) is a Kv7.2 channel modulator and can be used for study of epilepsy .

Kv7.2 modulator 2	Potassium Channel	Neurological Disease
Kv7.2 modulator 2 (compound 52) is a Kv7.2 channel modulator and can be used for study of epilepsy .

Kv7.2/Kv7.3 activator-1	Potassium Channel	Neurological Disease
Kv7.2/Kv7.3 activator-1 (compound 517) is a potent *Kv7.2/Kv7.3* channel activator with an EC₅₀ value of ＜1 µM. Kv7.2/Kv7.3 activator-1 has the potential for the research of neurological diseases .

XE991	Potassium Channel	Neurological Disease
XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC₅₀s of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively .

ML252 hydrochloride	Potassium Channel Cytochrome P450	Neurological Disease
ML252 hydrochloride is a selective inhibitor of KCNQ2 (Kv7.2) channel with IC₅₀s of 69 nM, 2.92 μM, 0.12 μM and 0.20 μM for KCNQ2, KCNQ1 (Kv7.1), KCNQ2/Q3 and KCNQ4, respectively. ML252 hydrochloride also inhibits Cytochrome P450 with IC₅₀s of 6.1 nM (CYP1A2), 18.9 nM (CYP2C9), 3.9 nM (CYP3A4), 19.9 nM (CYP2D6), respectively. ML252 hydrochloride shows highly brain penetrant .

ICA-105665 PF-04895162	Potassium Channel	Neurological Disease
ICA-105665 (PF-04895162) is a potent and orally active neuronal *Kv7.2/7.3* and Kv7.3/7.5 potassium channels opener. ICA-105665 inhibits liver mitochondrial function and bile salt export protein (BSEP) transport (IC₅₀ of 311 μM). ICA-105665 can penetrate the blood-brain barrier and has antiseizure effects .

ICA-069673 2 Publications Verification	Potassium Channel	Neurological Disease
ICA-069673 is a KCNQ2/Q3 potassium channel activator. ICA-069673 demonstrates greater selectivity for *KV7.2/7.3* over *KV7.3/KV7.5, with EC₅₀*s of 0.69 μM and 14.3 μM, respectively. ICA-069673 inhibits spontaneous phasic and nerve-evoked contractions in guinea pig detrusor smooth muscle (DSM). ICA-069673 also decreases the global intracellular Ca(2+) concentration in DSM cells .

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