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25

Inhibitors & Agonists

1

Biochemical Assay Reagents

6

Peptides

4

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-106783
    Polymyxin B nonapeptide
    1 Publications Verification

    		 Bacterial Antibiotic Infection
    Polymyxin B nonapeptide is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes .
    Polymyxin B nonapeptide
  • HY-106783A
    Polymyxin B nonapeptide TFA
    1 Publications Verification

    		 Bacterial Antibiotic Infection
    Polymyxin B nonapeptide TFA is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide TFA is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes .
    Polymyxin B nonapeptide TFA
  • HY-131583
    MP265

    4-Chlorobenzyl carbamimidothioate hydrochloride

    		 Others Infection
    MP265 (4-Chlorobenzyl carbamimidothioate hydrochloride) is a structural analogue of A22 but is less toxic. MP265 is a MreB inhibitor .
    MP265
  • HY-N6774
    Cytochalasin C
    1 Publications Verification

    		 Others Infection
    Cytochalasin C is a cell-permeable fungal toxin and induces the formation of nuclear rodlets. Cytochalasin C is 10 times less toxic in mice than is cytochalasin D .
    Cytochalasin C
  • HY-B1785
    5-Sulfosalicylic acid

    Sulfosalicylic acid; Sulphosalicylic acid; Salicylsulfonic acid

    		 Others Cancer
    5-Sulfosalicylic acid is a sulfonated salicylic acid derivative. 5-Sulfosalicylic acid is effective against the breast cancer cell lines, with less toxicity . 5-Sulfosalicylic acid has antioxidant activities .
    5-Sulfosalicylic acid
  • HY-159155
    CDK2/4-IN-1

    		CDK Microtubule/Tubulin Cancer
    CDK2/4-IN-1 (compound B-4a) is a CDK2/4 inhibitor and a tubulin polymerization inhibitor. CDK2/4-IN-1 can be used in cancer research .
    CDK2/4-IN-1
  • HY-121350
    Merodantoin

    		Others Cancer
    Merodantoin has significant antitumor activity in vitro and in vivo, and has less toxicity to normal cells and tissues .
    Merodantoin
  • HY-N6721
    T-​2 Tetraol

    		Others Infection
    T-​2 Tetraol is a metabolite of T-2 toxin, and also a trichothecene mycotoxin, with less toxicity and is unable to induce apoptosis .
    T-​2 Tetraol
  • HY-B0230A
    Thiazolinobutazone

    LAS 11871

    		 COX Inflammation/Immunology
    Thiazolinobutazone is a COX inhibitor. Thiazolinobutazone has less toxic than Phenylbutazone (HY-B0230). Thiazolinobutazone can be used in the study of immunological diseases .
    Thiazolinobutazone
  • HY-149240
    Anticancer agent 108

    		P-glycoprotein Cancer
    Anticancer agent 108 (Compound 3.10) is a potent P-gp inhibitor with significant antitumor activity and less toxicity to normal and pseudonormal cells. Anticancer agent 108 (Compound 3.10) had no acute toxic effect on С57BL/6 mice .
    Anticancer agent 108
  • HY-119779
    Pyridalyl

    S 1812

    		 Others Others
    Pyridalyl (S 1812) is an insecticides against Lepidoptera and Thrips. Pyridalyl is less toxic to some beneficial arthropods, and non-target organisms, such as mammals and fish, and thus be utilized in integrated pest management and resistance management .
    Pyridalyl
  • HY-161327
    HBV-IN-44

    		HBV Infection
    HBV-IN-44 (Compound (S)-2a) is a HBV inhibitor with a IC50 value of 23 nM for HbsAg. HBV-IN-44 is less toxic to the neurite growth of HT22 cells and DRG neurons in vitro .
    HBV-IN-44
  • HY-138149
    2-epi-Abamectin

    epi-Avermectin B1a

    		 Others Infection
    2-epi-Abamectin is a degradation product of Abamectin. It is toxic to the two-spotted spider mite in a contact assay with an LC50 value of 4 ppm, which is approximately 100-fold less potent than abamectin.
    2-epi-Abamectin
  • HY-N1658
    2,3-Dihydroisoginkgetin

    		Tyrosinase Others
    2,3-Dihydroisoginkgetin, a biflavonoid, is a inhibitor of Tyrosinase, with 36.84% inhibition at 0.1 mM. 2,3-Dihydroisoginkgetin shows less toxicity in HEMn (human epidermal melanocytes) cells, with an IC50 of 86.16 μM .
    2,3-Dihydroisoginkgetin
  • HY-B0812
    5-Sulfosalicylic acid dihydrate

    SSA dihydrate

    		 Biochemical Assay Reagents Cancer
    5-Sulfosalicylic acid dihydrate is a sulfonated salicylic acid derivative. 5-Sulfosalicylic acid dihydrate is effective against the breast cancer cell line, MCF-7, with less toxicity . 5-Sulfosalicylic acid dihydrate has antioxidant activities .
    5-Sulfosalicylic acid dihydrate
  • HY-106364
    Peplomycin

    Bleomycin PEP; Pepleomycin

    		 Antibiotic Cancer
    Peplomycin (Bleomycin PEP; Pepleomycin) is an antibiotic analogue of Bleomycin (HY-108345), with high antitumor effect and less pulmonary toxicity. Peplomycin induce apoptosis in oral squamous carcinoma cell line SSCKN cells and pulmonary fibrosis in rats .
    Peplomycin
  • HY-14922
    Fosalvudine tidoxil

    		Reverse Transcriptase HIV Infection
    Fosalvudine tidoxil is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Fosalvudine tidoxil is a prodrug derived from Alovudine (HY-B1516). Fosalvudine tidoxil is less toxic than Alovudine and can be used for the research of HIV-1 infection .
    Fosalvudine tidoxil
  • HY-114577
    Palifosfamide tromethamine

    Isophosphoramide mustard tromethamine; IPM tromethamine; ZIO-201 tromethamine

    		 DNA Alkylator/Crosslinker Cancer
    Palifosfamide (tromethamine) is a synthetic alkylating agent with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide (tromethamine) irreversibly alkylates and crosslinks DNA through GC base pairs. This leads to an inhibition of DNA replication and ultimately cell death. Compared to ifosfamide, palifosfamide (tromethamine) is less toxic.
    Palifosfamide tromethamine
  • HY-149822
    Antifungal agent 51

    		Fungal Infection
    Antifungal agent 51 (Compound 5c) has potent antifungal activity, especially against Candida albicans FDC 151 , Candida parapsilosis ATCC 22019 and Candida tropicalis FDC 138, with the MIC value is less than 0.063 μg/mL, and it has low toxicity to cells and no carcinogenicity .
    Antifungal agent 51
  • HY-147916
    RNA polymerase II-IN-1

    		DNA/RNA Synthesis Cancer
    RNA polymerase II-IN-1 (compound 19iv) is a amatoxin, inhibiting RNA polymerase II (Pol II) with an IC50 value of 36.66 nM. RNA polymerase II-IN-1 has higher cytotoxicity against cancer cells and less toxic in normal cells than α-Amanitin .
    RNA polymerase II-IN-1
  • HY-15785
    Pimitespib
    3 Publications Verification

    TAS-116

    		 HSP Cancer
    Pimitespib (TAS-116) is an oral bioavailable, ATP-competitive, highly specific HSP90α/HSP90β inhibitor (Kis of 34.7 nM and 21.3 nM, respectively) without inhibiting other HSP90 family proteins such as GRP94 . Pimitespib demonstrates less ocular toxicity .
    Pimitespib
  • HY-N6720
    T-2 Triol

    		Endogenous Metabolite Metabolic Disease
    T-2 Triol is a trichothecene mycotoxin derived by the metabolism of T-2 toxin. It is less toxic than T-2 toxin . T-2 Triol major metabolites are evaluated in broiler chickens with Half-lives (t1/2λz), Peak plasma concentrations (Cmax) and Tmax values of 9.6 mins, 563 ng/ml , 2.5 mins, respectively .
    T-2 Triol
  • HY-W014566
    4-Nitro-3-(trifluoromethyl)phenol

    3-(Trifluoromethyl)-4-Nitrophenol; TFM

    		 Others Infection
    4-Nitro-3-(trifluoromethyl)phenol (TFM) is a piscicide. It is toxic to sea lamprey (P. marinus) with LC50 values ranging from 1.97 to 2.11 and 2.05 to 2.21 mg/L for sac and swim-up fry, respectively, 1.6 to 2.45 mg/L for juveniles, and 1.6 to 1.63 mg/L for adults. It is also toxic to juvenile lake sturgeon (A. fulvescens) less than 100 mm in size but not to a variety of other fish species. 4-Nitro-3-(trifluoromethyl)phenol (TFM) (50 μM) uncouples oxidative phosphorylation by 22 and 28% in isolated sea lamprey and rainbow trout (O. mykiss) liver, respectively. 4-Nitro-3-(trifluoromethyl)phenol (TFM) has been used as lampricides in the control of larval sea lamprey populations.
    4-Nitro-3-(trifluoromethyl)phenol
  • HY-130604
    DT2216
    1 Publications Verification

    		 Bcl-2 Family PROTACs Apoptosis Cancer
    DT2216 is a potent and selective BCL-XL (Bcl-2 family member) degrader based on PROTAC technology. DT2216 causes effective degradation of BCL-XL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. DT2216 inhibits various BCL-XL-dependent leukemia and cancer cells but considerably less toxic to platelets. DT2216 is composed of the Bcl-2 family protein inhibitor Navitoclax (HY-10087), a linker, and a VHL E3 ubiquitin ligase (Red: Navitoclax; Blue: VHL ligand; Black: linker) .
    DT2216
  • HY-149091
    KDM5B-IN-4

    		Others Cancer
    KDM5B-IN-4 (compound 11ad) is a lysine demethylase 5B (KDM5B) inhibitor with an IC50 of 0.025 μM KDM5B-IN-4 increases substrate H3K4me1/2/3 level by inhibiting KDM5B in PC-3 cells. KDM5B-IN-4 downregulates PI3K/AKT. KDM5B-IN-4 reduces tumor volume in mice and shows less toxic to organs .
    KDM5B-IN-4

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