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  4. 5-Sulfosalicylic acid

5-Sulfosalicylic acid  (Synonyms: Sulfosalicylic acid; Sulphosalicylic acid; Salicylsulfonic acid)

Cat. No.: HY-B1785 Purity: ≥96.0%
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5-Sulfosalicylic acid is a sulfonated salicylic acid derivative. 5-Sulfosalicylic acid is effective against the breast cancer cell lines, with less toxicity. 5-Sulfosalicylic acid has antioxidant activities.

For research use only. We do not sell to patients.

5-Sulfosalicylic acid Chemical Structure

5-Sulfosalicylic acid Chemical Structure

CAS No. : 97-05-2

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Based on 1 publication(s) in Google Scholar

Other Forms of 5-Sulfosalicylic acid:

5-Sulfosalicylic acid Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

5-Sulfosalicylic acid is a sulfonated salicylic acid derivative. 5-Sulfosalicylic acid is effective against the breast cancer cell lines, with less toxicity[1]. 5-Sulfosalicylic acid has antioxidant activities[2].

In Vitro

5-Sulfosalicylic acid (0.5-4 mM, 24 h) shows a reduction in the viability of MCF-7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5-Sulfosalicylic acid Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: MCF-7 and HUVEC cells
Concentration: 0.5, 1, 2, 4 mM
Incubation Time: 24 hours
Result: Showed the viability of 63.3% and 70.4% in MCF-7 and HUVEC control cells respectively at 1 mM 5-Sulfosalicylic acid.
Molecular Weight

218.18

Formula

C7H6O6S
CAS No.
Appearance

Oil

Color

White to off-white

SMILES

O=C(O)C1=CC(S(=O)(O)=O)=CC=C1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1145.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5834 mL 22.9169 mL 45.8337 mL
5 mM 0.9167 mL 4.5834 mL 9.1667 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (9.53 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (9.53 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.5834 mL 22.9169 mL 45.8337 mL 114.5843 mL
5 mM 0.9167 mL 4.5834 mL 9.1667 mL 22.9169 mL
10 mM 0.4583 mL 2.2917 mL 4.5834 mL 11.4584 mL
15 mM 0.3056 mL 1.5278 mL 3.0556 mL 7.6390 mL
20 mM 0.2292 mL 1.1458 mL 2.2917 mL 5.7292 mL
25 mM 0.1833 mL 0.9167 mL 1.8333 mL 4.5834 mL
30 mM 0.1528 mL 0.7639 mL 1.5278 mL 3.8195 mL
40 mM 0.1146 mL 0.5729 mL 1.1458 mL 2.8646 mL
50 mM 0.0917 mL 0.4583 mL 0.9167 mL 2.2917 mL
60 mM 0.0764 mL 0.3819 mL 0.7639 mL 1.9097 mL
80 mM 0.0573 mL 0.2865 mL 0.5729 mL 1.4323 mL
100 mM 0.0458 mL 0.2292 mL 0.4583 mL 1.1458 mL
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5-Sulfosalicylic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Sulfosalicylic acid97-05-2Sulfosalicylic acid Sulphosalicylic acid Salicylsulfonic acidOthersMCF-7HUVECbreast cancerantitumor agentantioxidant activityInhibitorinhibitorinhibit

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