2. Anti-infection
  3. Reverse Transcriptase HIV
  4. Fosalvudine tidoxil

Fosalvudine tidoxil is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Fosalvudine tidoxil is a prodrug derived from Alovudine (HY-B1516). Fosalvudine tidoxil is less toxic than Alovudine and can be used for the research of HIV-1 infection.

For research use only. We do not sell to patients.

Fosalvudine tidoxil Chemical Structure

Fosalvudine tidoxil Chemical Structure

CAS No. : 763903-67-9

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Fosalvudine tidoxil Related Antibodies

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Description

Fosalvudine tidoxil is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Fosalvudine tidoxil is a prodrug derived from Alovudine (HY-B1516). Fosalvudine tidoxil is less toxic than Alovudine and can be used for the research of HIV-1 infection[1].

IC50 & Target

Nucleoside reverse transcriptase[1]
In Vivo

Fosalvudine tidoxil (15-100 mg/kg/day; oral; 8 weeks) induces significant mitochondrial hepatotoxicity in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats[1]
Dosage: 15, 40, or 100 mg/kg/day
Administration: Oral gavage, 8 weeks
Result: Induced significant mtDNA depletion. At doses of 15, 40, and 100 mg/kg, the mean hepatic mtDNA values were 62, 64, and 47% of control values, respectively.
Molecular Weight

722.93

Formula

C35H64FN2O8PS
CAS No.
SMILES

O=P(OC[C@H]1O[C@@H](N(C(N2)=O)C=C(C)C2=O)C[C@@H]1F)(OCC(OCCCCCCCCCC)CSCCCCCCCCCCCC)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Fosalvudine tidoxil Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fosalvudine tidoxil763903-67-9Reverse TranscriptaseHIVHuman immunodeficiency virusmitochondrial hepatotoxicitymtDNASprague-Dawley ratsInhibitorinhibitorinhibit

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