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Results for "

MAIT

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Biochemical Assay Reagents (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (3) Neurological Disease (1)

5

Inhibitors & Agonists

1

Peptides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

RL-6-Me-7-OH	Biochemical Assay Reagents	Inflammation/Immunology
RL-6-Me-7-OH is a hapten that activates human and mouse MAIT cells (EC₅₀=25µM). RL-6-Me-7-OH can be combined with carrier proteins and used in antigen design. RL-6-Me-7-OH can be used in inflammation and immunity research .

5-A-RU-PABC-Val-Cit-Fmoc 2 Publications Verification	Others	Inflammation/Immunology
5-A-RU-PABC-Val-Cit-Fmoc is the proagent of 5-A-RU . 5-A-RU, a precursor of bacterial Riboflavin, is a *mucosal-associated invariant T (MAIT) cells* activator. 5-A-RU forms potent MAIT-activating antigens via non-enzymatic reactions with small molecules, such as glyoxal and methylglyoxal, which are derived from other metabolic pathways .

DB28	Others	Others
DB28 is a novel MR1 ligand. DB28 decreases cell surface expression of MR1 and competitively inhibits activation of MAIT cells by agonist ligands .

RWJ52353	Adrenergic Receptor	Neurological Disease
RWJ52353 is a selective, orally active ligand for α2D adrenoceptor, which binds α2D, α2A, α2B and α1 receptors, with K_is of 1.5, 254, 621 and 443 nM. RWJ52353 exhibits analgesic efficacy in mouse abdominal irritation test (MAIT), with an ED₅₀ of 15.1 mg/kg .

Photolumazine I PLI	Others	Inflammation/Immunology
Photolumazine I(PLI) is a vitamin B-based hapten.Photolumazine Icanactivates Mucosal-associated Invariant T clones .

Cat. No.	Product Name	Target	Research Area

MAIT-203	Peptides	Cancer
MAIT-203, a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. MAIT-203 binds APC-ARM with a K_i of 0.015 μM and a K_d of 0.036 μM. MAIT-203 significantly represses the migration and invasion of colorectal cancer cells.

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