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MGL-IN-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (4) Bacterial (8) Dihydrofolate reductase (DHFR) (1) DNA/RNA Synthesis (1) Endogenous Metabolite (3) Fungal (7) GABA Receptor (1) Glucosidase (1) Histone Demethylase (1) MAGL (1) Parasite (3) Succinate Dehydrogenase (2) Topoisomerase (1)
By Research Areas:	Cancer (5) Infection (20) Inflammation/Immunology (3)

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Peptides

Natural
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Targets Recommended: AIM2 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-119033

*MGL-IN-1*	MAGL	Inflammation/Immunology
MGL-IN-1 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. MGL-IN-1 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model in vivo. MGL-IN-1 displays high membrane permeability and brain penetrant ^[1].

HY-122298

Fenpicoxamid XDE 777	Antibiotic Fungal	Infection
Fenpicoxamid is a new fungicide. Fenpicoxamid inhibits the growth of the fungus Z. tritici with an EC₅₀ value of 0.051 mg/L .

HY-149399

GABA-IN-1	Others	Infection
GABA-IN-1 (Compound 6) is a GABA inhibitor. GABA-IN-1 has larvicidal activity and insecticidal effect, with mortality rates of 93% at 50 mg/L .

HY-149400

GABA-IN-2	Others	Infection
GABA-IN-2 (Compound 5) is a GABA inhibitor. GABA-IN-2 has larvicidal activity and insecticidal effect, with mortality rates of 87% at 50 mg/L .

HY-168527

Acaricide	Histone Demethylase	Cancer
Acaricide (Compound 7l) is a potent *LSD1* inhibitor. LSD1 exhibits excellent acaricidal activity against egg of T. cinnabarinus with a LC₅₀ of 0.0035 mg/L .

HY-155334

RyRs activator 4	Others	Others
RyRs activator 4 (compound B18) is an insect ryanodine receptor activator. RyRs activator 4 has a larvicidal activity of Mythimna separata with an LC₅₀ value of 1.32 mg/L .

HY-155700

SDH-IN-6	Fungal	Infection
SDH-IN-6 (compound 6i) is a potent succinate dehydrogenase (SDH) inhibitor. SDH-IN-6 has antifungal activity against Valsa mali with an EC₅₀ value of 1.77 mg/L .

HY-N9075

9-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one	Glucosidase	Cancer
9-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one is a phytoalexin and mixed competitive α-glucosidase inhibitor of Bacillus stearothermophilus (IC₅₀: 3.86 mg/L) .

HY-N3706

Dehydro-α-lapachone	Fungal	Infection
Dehydro-α-lapachone can be isolated from the methanol extract of stems of Catalpa ovata G Don. Dehydro-α-lapachone inhibits mycelial growth of Botrytis cinerea with IC₅₀ value 0.41 mg/L .

HY-19806

Ceftolozane CXA-101 free base; FR264205 free base	Bacterial	Infection
Ceftolozane (CXA-101 free base; FR264205 free base) is a cephalosporin antibiotic with potent activity againstPseudomonas aeruginosa and strains Enterobacteriaceae, with MICs of 0.5 and 0.25-0.5 mg/L .

HY-N1673

2,5-Dihydroxybenzaldehyde Gentisaldehyde	Bacterial	Infection
2,5-Dihydroxybenzaldehyde (Gentisaldehyde) is a naturally occurring antimicrobial that inhibits the growth of *Mycobacterium avium subsp. paratuberculosis. 2,5-Dihydroxybenzaldehyde is active against S. aureus* strains with a MIC₅₀ of 500 mg/L .

HY-146109

RyRs activator 1	Parasite	Infection
RyRs activator 1 (compound 7f) is a potent activator of ryanodine receptors (RyRs). RyRs activator 1 at 0.5 mg/L displays 100% larvicidal activity. The larvicidal activity of RyRs activator 1 is 90% at 0.01 mg/L .

HY-128780

Upleganan SPR206	Bacterial	Infection Cancer
Upleganan (SPR206), a polymyxin analogue, and shows antibiotic activity against multidrug resistant Gram-negative pathogen. The MIC values of Upleganan against *Pseudomonas aeruginosa* Pa14 and *Acinetobacter baumannii* NCTC13301 are both 0.125 mg/L .

HY-163560

Insecticidal agent 10	Parasite	Others
Insecticidal agent 10 (Compound 8c) is an inhibitor for chitinase, which inhibits OfChi-h and OfChtI with IC₅₀ of 1.51 and 9.21 nM, respectively. Insecticidal agent 10 inhibits growth of Ostrinia furnacalis with LC₅₀ of 22.14 mg/L .

HY-158112

Herbicidal agent 3	Others	Others
Herbicidal agent 3 (compound 7A) shows herbicidal activity against Digitaria sanguinalis and Amaranthus retroflexus at a dosage of 90 g ai/ha. Herbicidal agent 3 inhibites Setaria viridis TKL (SvTKL) enzyme activity, with the IC₅₀ of 0.740 mg/L .

HY-157015

Antifungal agent 81	Fungal	Infection
Antifungal agent 81(G22)exhibitsexcellent in vitro antifungal activities against Valsa mali withIC₅₀values of 0.48 mg/L. Antifungal agent 81also exhibits excellent in vivo protective againstV. maliat 40 mg/L .

HY-139983

SDH-IN-1 1 Publications Verification	Fungal	Infection
SDH-IN-1 (compound 4i) is a succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 4.53 μM. SDH-IN-1 has potent antifungal activities. SDH-IN-1 displays potent activity against *S. sclerotiorum* (EC₅₀ of 0.14 mg/L) .

HY-159486

SDH-IN-18	Succinate Dehydrogenase Fungal	Infection
SDH-IN-18 (Compound 3a) is an inhibitor for succinate dehydrogenase (SDH) with an IC₅₀ of 8.70 mg/L. SDH-IN-18 destroys fungal morphology and reproduction, exhibits antifungal activity against Rhizoctonia solani and Sclerotinia sclerotiorum with EC₅₀ of 0.48 and 1.4 mg/L .

HY-N10269

Phomalactone	Fungal Endogenous Metabolite	Infection
Phomalactone, produced by the fungus Nigrospora sphaerica, specifically inhibits the mycelial growth of Phytophthora infestans, with an MIC value of 2.5 mg/L . Phomalactone is phytotoxic to Z. elegans and other plant species by inhibition of seedling growth and by causing electrolyte leakage from photosynthetic tissues of both Z. elegans leaves and cucumber cotyledons .

HY-14780

Viquidacin NXL 101	Antibiotic Topoisomerase DNA/RNA Synthesis Bacterial	Infection
Viquidacin (NXL 101) is an antibiotic with inhibitory activity against topoisomerase IV and DNA gyrase. Viquidacin exhibits antibacterial activity against gram positive bacterial by inhibiting the supercoiling, decatenation and relaxation in strains Staphylococcus aureus and Escherichia coli in micromolar levels. Viquidacin inhibits S. aureus wildtype and mutants with MIC of 2-128 mg/L .

HY-163890

Succinate dehydrogenase-IN-2	Succinate Dehydrogenase Parasite	Infection
Succinate dehydrogenase-IN-2 (Compound 12x) is an inhibitor for succinate dehydrogenase (SDH) with an IC₅₀ of 1.22 mg/L. Succinate dehydrogenase-IN-2 exhibits antifungal activity, that inhibits S. sclerotiorum, V. mali, G. graminis, R. solani and B. cinerea with EC₅₀ of 0.52-3.42 mg/L .

HY-N10069

Bonducellin	Others	Infection
Bonducellin is a a homoisoflavonoid, which can be isolated from Caesalpinia digyna roots. Bonducellin is a potent inhibitor of efflux pump (EP), while EP induces resistance in mycobacteria and serves as a target of anti-TB (tuberculosis) agents. Bonducellin reduces MIC of EtBr by 8-fold against M. smegmatis (MIC=62.5 mg/L) .

HY-118906

BO-1165	Antibiotic Bacterial	Infection
BO-1165 is an antibiotic with good antibacterial activity against Gram-negative bacteria, but almost no activity against Gram-positive bacteria and anaerobic bacteria. BO-1165 has high antibacterial activity against Pseudomonas aeruginosa (MIC₅₀=3.12 mg/L) and P. cepacia (MIC₅₀=1.56 mg/L) .

HY-128780B

SPR206 acetate 1 Publications Verification	Bacterial Antibiotic	Infection
SPR206 acetate is a polymyxin analog with antibiotic activity against Gram-negative pathogens, including multidrug-resistant (MDR) variants. SPR206 acetate has an anti-bacterial infection effect by interacting with the bacterium’s outer membrane. The MIC values of SPR206 acetate against *Pseudomonas aeruginosa* Pa14 and *Acinetobacter baumannii* NCTC13301 are both 0.125 mg/L .

HY-W272217

Octacosane n-Octacosane; NSC 5549	Endogenous Metabolite Bacterial	Inflammation/Immunology Cancer
Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC₅₀ concentration of 7.2 mg/l .

HY-161010

DHFR-IN-13	Dihydrofolate reductase (DHFR)	Infection
DHFR-IN-13 (Compd Hit8) is an active R. solani DHFR inhibitor with an IC₅₀ value of 10.2 μM. DHFR-IN-13 has selectivity of inhibition against human DHFR with an IC₅₀ value of 227.7 μM. DHFR-IN-13 also is a fungicide. DHFR-IN-13 has high antifungal activity against R. solani with EC₅₀ value of 38.2 mg/L .

HY-W272217R

Octacosane (Standard)	Endogenous Metabolite Bacterial	Inflammation/Immunology Cancer
Octacosane (Standard) is the analytical standard of Octacosane. This product is intended for research and analytical applications. Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l .

HY-156339

GABA receptor Antagonist 1	GABA Receptor	Others
GABA receptor Antagonist 1 (compound 7w) inhibits Px RDL1 GABAR with an IC₅₀ value of 7.08 nmol/L. GABA receptor Antagonist 1 shows insecticide activity against P. xylostella, S. frugiperda, S. exigua, and S. litura, with LC₅₀ of 0.09, 0.84, 0.87, and 0.68 mg/L respectively. GABA receptor Antagonist 1 shows a medium toxicity to honeybee (48 h, ID₅₀ = 2.22 μg/adult), and low toxicity to zebrafish (LC₅₀: 42.4 mg/L) .

Cat. No.	Product Name	Target	Research Area

HY-P5663

Bombinin H-BO1	Peptides	Infection
Bombinin H-BO1 is an antimicrobial peptide derived from toad Bombina orientalis skin secretions. Bombinin H-BO1 is active against Candida albicans, and the MIC value is 256 mg/L .

2,5-Dihydroxybenzaldehyde Gentisaldehyde	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Disease Research Fields	Bacterial
2,5-Dihydroxybenzaldehyde (Gentisaldehyde) is a naturally occurring antimicrobial that inhibits the growth of *Mycobacterium avium subsp. paratuberculosis. 2,5-Dihydroxybenzaldehyde is active against S. aureus* strains with a MIC₅₀ of 500 mg/L .

Octacosane n-Octacosane; NSC 5549	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Endogenous Metabolite Bacterial
Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC₅₀ concentration of 7.2 mg/l .

9-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one	Structural Classification Monophenols Source classification Phenols Musaceae Plants Musa basjoo Sieb. et Zucc.	Glucosidase
9-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one is a phytoalexin and mixed competitive α-glucosidase inhibitor of Bacillus stearothermophilus (IC₅₀: 3.86 mg/L) .

Dehydro-α-lapachone	Structural Classification Natural Products Catalpa ovata G. Don Source classification Plants Bignoniaceae	Fungal
Dehydro-α-lapachone can be isolated from the methanol extract of stems of Catalpa ovata G Don. Dehydro-α-lapachone inhibits mycelial growth of Botrytis cinerea with IC₅₀ value 0.41 mg/L .

Phomalactone	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Fungal Endogenous Metabolite
Phomalactone, produced by the fungus Nigrospora sphaerica, specifically inhibits the mycelial growth of Phytophthora infestans, with an MIC value of 2.5 mg/L . Phomalactone is phytotoxic to Z. elegans and other plant species by inhibition of seedling growth and by causing electrolyte leakage from photosynthetic tissues of both Z. elegans leaves and cucumber cotyledons .

Bonducellin	Structural Classification Flavonoids Leguminosae Caesalpinia sappan L. Source classification Plants Other Flavonoids	Others
Bonducellin is a a homoisoflavonoid, which can be isolated from Caesalpinia digyna roots. Bonducellin is a potent inhibitor of efflux pump (EP), while EP induces resistance in mycobacteria and serves as a target of anti-TB (tuberculosis) agents. Bonducellin reduces MIC of EtBr by 8-fold against M. smegmatis (MIC=62.5 mg/L) .

Octacosane (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite Bacterial
Octacosane (Standard) is the analytical standard of Octacosane. This product is intended for research and analytical applications. Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l .

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MGL-IN-1

Inhibitors & Agonists

Peptides

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Natural
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