2. Anti-infection
  3. Bacterial
  4. Ceftolozane

Ceftolozane  (Synonyms: CXA-101 free base; FR264205 free base)

Cat. No.: HY-19806
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Ceftolozane (CXA-101 free base; FR264205 free base) is a cephalosporin antibiotic with potent activity againstPseudomonas aeruginosa and strains Enterobacteriaceae, with MICs of 0.5 and 0.25-0.5 mg/L.

For research use only. We do not sell to patients.

Ceftolozane Chemical Structure

Ceftolozane Chemical Structure

CAS No. : 689293-68-3

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Other Forms of Ceftolozane:

Ceftolozane Related Antibodies

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Description

Ceftolozane (CXA-101 free base; FR264205 free base) is a cephalosporin antibiotic with potent activity againstPseudomonas aeruginosa and strains Enterobacteriaceae, with MICs of 0.5 and 0.25-0.5 mg/L[1].

In Vivo

Ceftolozane (25 mg/kg) reveals a pharmacokinetic profil with a half-time of 11.6 min and a clearance of 25.2 μg/mL in infected neutropenic mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

666.69

Formula

C23H30N12O8S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN1[N+](CC(CS[C@]2([H])[C@@H]3NC(/C(C4=NSC(N)=N4)=N\OC(C)(C(O)=O)C)=O)=C(C([O-])=O)N2C3=O)=CC(NC(NCCN)=O)=C1N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 24 mg/mL (36.00 mM; ultrasonic and adjust pH to 2 with HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4999 mL 7.4997 mL 14.9995 mL
5 mM 0.3000 mL 1.4999 mL 2.9999 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4999 mL 7.4997 mL 14.9995 mL 37.4987 mL
5 mM 0.3000 mL 1.4999 mL 2.9999 mL 7.4997 mL
10 mM 0.1500 mL 0.7500 mL 1.4999 mL 3.7499 mL
15 mM 0.1000 mL 0.5000 mL 1.0000 mL 2.4999 mL
20 mM 0.0750 mL 0.3750 mL 0.7500 mL 1.8749 mL
25 mM 0.0600 mL 0.3000 mL 0.6000 mL 1.4999 mL
30 mM 0.0500 mL 0.2500 mL 0.5000 mL 1.2500 mL
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Ceftolozane Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ceftolozane689293-68-3CXA-101FR264205CXA101CXA 101FR 264205FR-264205BacterialPseudomonas aeruginosaEnterobacteriaceaeInhibitorinhibitorinhibit

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