Viquidacin (Synonyms: NXL 101)

Cat. No.: HY-14780: FAQs
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Viquidacin (NXL 101) is an antibiotic with inhibitory activity against topoisomerase IV and DNA gyrase. Viquidacin exhibits antibacterial activity against gram positive bacterial by inhibiting the supercoiling, decatenation and relaxation in strains Staphylococcus aureus and Escherichia coli in micromolar levels. Viquidacin inhibits S. aureus wildtype and mutants with MIC of 2-128 mg/L.

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Viquidacin Chemical Structure

CAS No. : 904302-98-3

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Topoisomerase Topo I Topo II

Biological Activity
Purity & Documentation
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Description	Viquidacin (NXL 101) is an antibiotic with inhibitory activity against topoisomerase IV and DNA gyrase. Viquidacin exhibits antibacterial activity against gram positive bacterial by inhibiting the supercoiling, decatenation and relaxation in strains Staphylococcus aureus and Escherichia coli in micromolar levels. Viquidacin inhibits S. aureus wildtype and mutants with MIC of 2-128 mg/L^[1].
Molecular Weight	504.64
Formula	C₂₅H₂₉FN₂O₄S₂
CAS No.	904302-98-3
SMILES	[H][C@@](C1)(C(O)=O)[C@@](CC[C@]([H])(O)C2=C(F)C=NC3=C2C=C(OC)C=C3)([H])CCN1CCSC4=CC=CS4
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. Black MT, et al., Mechanism of action of the antibiotic NXL101, a novel nonfluoroquinolone inhibitor of bacterial type II topoisomerases. Antimicrob Agents Chemother. 2008 Sep;52(9):3339-49. [Content Brief]

Viquidacin Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Viquidacin904302-98-3NXL 101NXL101NXL-101AntibioticTopoisomeraseDNA/RNA SynthesisBacterialEscherichia coliStaphylococcus aureusantibacterialInhibitorinhibitorinhibit

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