MGMT

Isoforms Recommended:	MGMT

By Targets:	Apoptosis (1) DNA Methyltransferase (6) DNA/RNA Synthesis (1) Glutathione Peroxidase (1) Histone Methyltransferase (1) Isotope-Labeled Compounds (1) Phosphatase (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (11) Cardiovascular Disease (1) Inflammation/Immunology (1) Neurological Disease (3)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-119390

AA-CW236	DNA Methyltransferase	Cancer
AA-CW236 is a MGMT (O6-methylguanine DNA methyltransferase) inhibitor. AA-CW236 targets MGMT active site Cys145 for covalent modification .

HY-13057

O6BTG-octylglucoside 3 Publications Verification Glucose-conjugated MGMT inhibitor	DNA Methyltransferase	Cancer
O6BTG-octylglucoside is a potent O ⁶-methylguanine-DNAmethyl-transferase (MGMT) inhibitor, with IC₅₀s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells.

HY-B0106

Levetiracetam 1 Publications Verification UCB L059	DNA Methyltransferase	Neurological Disease Cancer
Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing *MGMT*, thus increasing Temozolomide effectiveness. A chemosensitizer agent .

HY-13668

Lomeguatrib Maximum Cited Publications 6 Publications Verification PaTrin-2	DNA Methyltransferase	Cancer
Lomeguatrib is a O ⁶-methylguanine-DNA methyltransferase (MGMT) inhibitor, with IC₅₀s of 9 nM in cell-free assay and ～6?nM in MCF-7 cells.

HY-RS08411

MGMT Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MGMT Human Pre-designed siRNA Set A contains three designed siRNAs for MGMT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MGMT Human Pre-designed siRNA Set A MGMT Human Pre-designed siRNA Set A

HY-RS08412

Mgmt Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mgmt Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mgmt gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mgmt Mouse Pre-designed siRNA Set A Mgmt Mouse Pre-designed siRNA Set A

HY-RS08413

Mgmt Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mgmt Rat Pre-designed siRNA Set A contains three designed siRNAs for Mgmt gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mgmt Rat Pre-designed siRNA Set A Mgmt Rat Pre-designed siRNA Set A

HY-164496

KL-50	Others	Cancer
KL-50 is a selective toxin toward tumors that lack the DNA repair protein O ⁶-methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O ⁶-alkylguanine lesions. KL-50 activates DNA damage response pathways and cycle arrest in MGMT-cells, independent of mismatch repair (MMR). KL-50 is promising for research of brain tumors that lack the DNA repair protein MGMT .

HY-169002

PP5-IN-2	Phosphatase	Cancer
PP5-IN-2 is an orally active and selective protein phosphatase 5 (PP5) inhibitor with an IC₅₀ value of 0.9 μM. PP5-IN-2 activates p53 and downregulates cyclin D1 and MGMT, which shows potency in cell cycle arrest and reverses Temozolomide (TMZ) (HY-17364) resistance in the U87 MG cell line. PP5-IN-2 effectively inhibits tumor growth in the xenograft mouse model .

HY-146651

MPO-IN-4	Glutathione Peroxidase	Cardiovascular Disease Inflammation/Immunology
MPO-IN-4 (compound 12) is a potent and selective myeloperoxidase (MPO) inhibitor with an IC₅₀0 of 25 nM. MPO-IN-4 has no effect on methyl guanine methyl transferase (MGMT) .

HY-115690

K-TMZ	Others	Cancer
K-TMZ is a derivative of methyl ketone, which exhibits antitumor efficacy against O ⁶ -methylguanine DNA methyltransferase (MGMT) deficient cell. K-TMZ can be used for research of glioblastoma .

HY-162384

EPIC-0628	Histone Methyltransferase	Cancer
EPIC-0628 is an inhibitor of the HOTAIR-EZH2 interaction and promotes ATF3 expression. The long noncoding RNA HOTAIR has been found to regulate glioblastoma (GBM) progression and mediate DNA damage repair (DDR) by interacting with the catalytic subunit EZH2 of PRC2. EPIC-0628 also inhibits the ATF3-p38-E2F1 DDR pathway to inhibit the HR pathway and upregulates CDKN1A (p21) expression, causing cell cycle arrest. EPIC-0628 also synergizes with Temozolomide (TMZ) (HY-17364) to enhance its in vivo potency .

HY-B0106S

Levetiracetam-d6 UCB L059-d₆	Isotope-Labeled Compounds DNA Methyltransferase	Neurological Disease Cancer
Levetiracetam-d₆ is the deuterium labeled Levetiracetam. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent[1][2].

HY-B0106S1

Levetiracetam-d3 UCB L059-d₃	DNA Methyltransferase	Neurological Disease Cancer
Levetiracetam-d₃ is the deuterium labeled Levetiracetam. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent[1][2].

HY-W002585

O6-Benzylguanine 1 Publications Verification	DNA/RNA Synthesis Apoptosis	Cancer
O6-Benzylguanine, a guanine analog, is the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase *(MGMT/AGT)* inhibitor. O6-Benzylguanine acts as an AGT substrate, which transfers its benzyl group to the AGT cysteine residue, thereby irreversibly inactivating AGT and preventing DNA repair. O6-Benzylguanine induces tumor cell apoptosis. Antineoplastic activity .

Cat. No.	Compare	Product Name	Species	Source

HY-P70306

	MGMT Protein, Human (His) rHuMethylated-DNA--protein-cysteine methyltransferase/MGMT, His; Methylated-DNA--protein-cysteine methyltransferase; 6-O-methylguanine-DNAmethyltransferase; O-6-methylguanine-DNA-alkyltransferase; MGMT	Human	E. coli
	MGMT Protein crucially defends against O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA, using a suicide reaction to repair methylated nucleobases. It stoichiometrically transfers the methyl group to a cysteine residue, but this process irreversibly inactivates MGMT. The sacrificial nature of MGMT's function emphasizes its commitment to safeguarding cellular DNA integrity at the expense of its own activity. MGMT Protein, Human (His) is the recombinant human-derived MGMT protein, expressed by E. coli , with N-6*His labeled tag. The total length of MGMT Protein, Human (His) is 207 a.a., with molecular weight of ~27.0 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-B0106S

Levetiracetam-d6
Levetiracetam-d₆ is the deuterium labeled Levetiracetam. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent[1][2].

HY-B0106S1

Levetiracetam-d3
Levetiracetam-d₃ is the deuterium labeled Levetiracetam. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent[1][2].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80224

	MGMT Antibody	WB, IHC-P	Human
	MGMT Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 22 kDa, targeting to MGMT. It can be used for WB,IHC-P assays with tag free, in the background of Human.

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Cat. No.	Product Name		Classification

HY-RS08411

MGMT Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
MGMT Human Pre-designed siRNA Set A contains three designed siRNAs for MGMT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS08412

Mgmt Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Mgmt Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mgmt gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS08413

Mgmt Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Mgmt Rat Pre-designed siRNA Set A contains three designed siRNAs for Mgmt gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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