2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. KL-50

KL-50 is a selective toxin toward tumors that lack the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O6-alkylguanine lesions. KL-50 activates DNA damage response pathways and cycle arrest in MGMT-cells, independent of mismatch repair (MMR). KL-50 is promising for research of brain tumors that lack the DNA repair protein MGMT.

For research use only. We do not sell to patients.

KL-50 Chemical Structure

KL-50 Chemical Structure

CAS No. : 1161826-19-2

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10 mM * 1 mL in DMSO
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Description

KL-50 is a selective toxin toward tumors that lack the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O6-alkylguanine lesions. KL-50 activates DNA damage response pathways and cycle arrest in MGMT-cells, independent of mismatch repair (MMR). KL-50 is promising for research of brain tumors that lack the DNA repair protein MGMT[1][2].

Molecular Weight

226.17

Formula

C7H7FN6O2
CAS No.
Appearance

Solid

Color

Off-white to pink

SMILES

O=C(C(N=CN12)=C2N=NN(CCF)C1=O)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (442.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4215 mL 22.1073 mL 44.2145 mL
5 mM 0.8843 mL 4.4215 mL 8.8429 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4215 mL 22.1073 mL 44.2145 mL 110.5363 mL
5 mM 0.8843 mL 4.4215 mL 8.8429 mL 22.1073 mL
10 mM 0.4421 mL 2.2107 mL 4.4215 mL 11.0536 mL
15 mM 0.2948 mL 1.4738 mL 2.9476 mL 7.3691 mL
20 mM 0.2211 mL 1.1054 mL 2.2107 mL 5.5268 mL
25 mM 0.1769 mL 0.8843 mL 1.7686 mL 4.4215 mL
30 mM 0.1474 mL 0.7369 mL 1.4738 mL 3.6845 mL
40 mM 0.1105 mL 0.5527 mL 1.1054 mL 2.7634 mL
50 mM 0.0884 mL 0.4421 mL 0.8843 mL 2.2107 mL
60 mM 0.0737 mL 0.3685 mL 0.7369 mL 1.8423 mL
80 mM 0.0553 mL 0.2763 mL 0.5527 mL 1.3817 mL
100 mM 0.0442 mL 0.2211 mL 0.4421 mL 1.1054 mL
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KL-50 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KL-501161826-19-2KL50KL 50DNA/RNA SynthesistoxinMGMTDNA damagecycle arrestMGMT-cellsbrain tumorsInhibitorinhibitorinhibit

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