2. Epigenetics
  3. DNA Methyltransferase
  4. AA-CW236

AA-CW236 is a MGMT (O6-methylguanine DNA methyltransferase) inhibitor. AA-CW236 targets MGMT active site Cys145 for covalent modification.

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AA-CW236 Chemical Structure

AA-CW236 Chemical Structure

CAS No. : 1869921-96-9

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Based on 1 publication(s) in Google Scholar

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Description

AA-CW236 is a MGMT (O6-methylguanine DNA methyltransferase) inhibitor. AA-CW236 targets MGMT active site Cys145 for covalent modification[1].

Molecular Weight

400.78

Formula

C17H16ClF3N4O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(F)(F)OC1=CC=C(C2=C(CCl)N(CCC3=C(C)ON=C3C)N=N2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (62.38 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4951 mL 12.4757 mL 24.9513 mL
5 mM 0.4990 mL 2.4951 mL 4.9903 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4951 mL 12.4757 mL 24.9513 mL 62.3784 mL
5 mM 0.4990 mL 2.4951 mL 4.9903 mL 12.4757 mL
10 mM 0.2495 mL 1.2476 mL 2.4951 mL 6.2378 mL
15 mM 0.1663 mL 0.8317 mL 1.6634 mL 4.1586 mL
20 mM 0.1248 mL 0.6238 mL 1.2476 mL 3.1189 mL
25 mM 0.0998 mL 0.4990 mL 0.9981 mL 2.4951 mL
30 mM 0.0832 mL 0.4159 mL 0.8317 mL 2.0793 mL
40 mM 0.0624 mL 0.3119 mL 0.6238 mL 1.5595 mL
50 mM 0.0499 mL 0.2495 mL 0.4990 mL 1.2476 mL
60 mM 0.0416 mL 0.2079 mL 0.4159 mL 1.0396 mL
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AA-CW236 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AA-CW2361869921-96-9DNA MethyltransferaseDNMTsDNA MTasesMGMT inhibitorO6-methylguanine DNA methyltransferasecovalent modificationCys145Inhibitorinhibitorinhibit

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