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Results for "

MTA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Endogenous Metabolite (2) Histone Methyltransferase (10) Influenza Virus (1) Microtubule/Tubulin (1) Parasite (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (13) Infection (1) Metabolic Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139611

MRTX-1719	Histone Methyltransferase	Cancer
MRTX-1719 is a potent, orally active, selective *PRMT5•MTA* complex inhibitor, with IC₅₀ of 3.6 and 20.5 nM for *PRMT5•MTA* and PRMT5. MRTX-1719 binds to the *PRMT5•MTA* complex, with KD value of 0.14 pM. MRTX-1719 shows antineoplastic activity in vitro and in vivo, and can be used for cancer study .

HY-139611B

(S)-MRTX-1719	Histone Methyltransferase	Cancer
(S)-MRTX-1719 (example 16-7) is the S-enantiomer of MRTX-1719. (S)-MRTX-1719 is a *PRMT5/MTA* complex inhibitor, with an IC₅₀ of 7070 nM .

HY-156680

TNG-462	Histone Methyltransferase	Cancer
TNG-462 is an orally active and selective PRMT5 inhibitor with anti-tumor activity against methylthioadenosine phosphorylase (MTAP) deficiency and/or methylthioadenosine (MTA) accumulation cancers .

HY-139611C

MRTX-1719 hydrochloride	Histone Methyltransferase	Cancer
MRTX-1719 hydrochloride is a potent first-in-class selective inhibitor of the *PRMT5/MTA* complex, with an IC₅₀ of less than 10 nM in PRMT5/MTA MTAP ^DEL SDMA cells .

HY-138684

MRTX9768	Histone Methyltransferase	Cancer
MRTX9768 is a potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor .

HY-RS08746

MTA1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MTA1 Human Pre-designed siRNA Set A contains three designed siRNAs for MTA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MTA1 Human Pre-designed siRNA Set A MTA1 Human Pre-designed siRNA Set A

HY-RS08747

MTA2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MTA2 Human Pre-designed siRNA Set A contains three designed siRNAs for MTA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MTA2 Human Pre-designed siRNA Set A MTA2 Human Pre-designed siRNA Set A

HY-RS08748

MTA3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MTA3 Human Pre-designed siRNA Set A contains three designed siRNAs for MTA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MTA3 Human Pre-designed siRNA Set A MTA3 Human Pre-designed siRNA Set A

HY-163799

*PRMT5-MTA-IN-1*	Histone Methyltransferase	Cancer
PRMT5-MTA-IN-1 (Compound A9a) is an inhibitor for protein arginine methyltransferase *PRMT5-MTA. PRMT5-MTA-IN-1 inhibits the proliferation of colorectal cancer cell HCT116 wildtype and MTAP del mutant, with an IC₅₀* of 16 nM and 2.47 μM. PRMT5-MTA-IN-1 exhibits good liver microsomal stability and film permeability. PRMT5-MTA-IN-1 exhibits good pharmacokinetic characteristics in CD-1 mice .

HY-163737

ST-401	Microtubule/Tubulin	Cancer
ST-401, a microtubule-targeting agent (MTA), is a brain-penetrant microtubule (MT) assembly inhibitor. ST-401 disrupts microtubule (MT) function through gentle and reverisible reduction in MT assembly that triggers mitotic delay and cell death in interphase. ST-401 shows a potent antitumor activity .

HY-138684A

MRTX9768 hydrochloride	Histone Methyltransferase	Cancer
MRTX9768 hydrochloride is a potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor .

HY-162989

*PRMT5-MTA-IN-2*	Others	Cancer

HY-153390

AMG-193	Histone Methyltransferase	Cancer
AMG 193 is an orally active MTA-cooperative PRMT5 inhibitor with antitumor activity. AMG 193, when complexed with MTA, preferentially inhibits the growth of MTAP-deficient tumor cells by inhibiting PRMT5 (IC₅₀=0.107 μM), thereby protecting normal cells with wild-type MTAP .

HY-158143

PRMT5-IN-34	Histone Methyltransferase	Cancer
PRMT5-IN-34 (Compound C) is an inhibitor of MTA-cooperative Protein arginine methyltransferase 5 (PRMT5/MAT) .

HY-162783

AZ-PRMT5i-1	Histone Methyltransferase	Cancer
AZ-PRMT5i-1 (Compound 28) is an effective and orally active MTAP-selective PRMT5 inhibitor. AZ-PRMT5i-1 also demonstrates MTA cooperativity and exhibits both in vitro and in vivo antitumor activities, and can be used to study MTAP-deficient cancers .

HY-16938

5'-Methylthioadenosine 3 Publications Verification 5'-(Methylthio)-5'-deoxyadenosine; 5'-Deoxy-5'-(methylthio)adenosine; 5'-S-Methyl-5'-thioadenosine	Endogenous Metabolite Apoptosis Parasite	Metabolic Disease Cancer
5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis . 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis .

HY-N0086R

N6-Methyladenosine (Standard)	Influenza Virus Endogenous Metabolite	Infection
N6-Methyladenosine (Standard) is the analytical standard of N6-Methyladenosine. This product is intended for research and analytical applications. N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities. In Vitro: N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion . N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-16938

5'-Methylthioadenosine 3 Publications Verification 5'-(Methylthio)-5'-deoxyadenosine; 5'-Deoxy-5'-(methylthio)adenosine; 5'-S-Methyl-5'-thioadenosine	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Apoptosis Parasite
5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis . 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis .

HY-N0086R

N6-Methyladenosine (Standard)	Structural Classification Natural Products Microorganisms Source classification Endogenous metabolite	Influenza Virus Endogenous Metabolite
N6-Methyladenosine (Standard) is the analytical standard of N6-Methyladenosine. This product is intended for research and analytical applications. N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities. In Vitro: N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion . N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits .

Species:	Human (2)
Tag:	GST (1) Flag (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P702912

	METTL3 Protein, Human (sf9, FLAG) MTA70	Human	Sf9 insect cells
	METTL3 Protein, Human (sf9, FLAG) is the recombinant human-derived METTL3, expressed by Sf9 insect cells , with N-Flag labeled tag. ,

HY-P703029

	METTL3 Protein, Human (sf9, GST) MTA70	Human	Sf9 insect cells
	METTL3 Protein, Human (sf9, GST) is the recombinant human-derived METTL3, expressed by Sf9 insect cells , with GST labeled tag. ,

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HY-P83599

	MTA2 Antibody (YA3344) Mata1l1; Metastasis associated gene 1 like 1; Metastasis associated gene family member 2; MMTA2; MTA1L1; p53 target protein in deacetylase complex; PID	WB, IHC-P, ICC/IF, FC	Human
	MTA2 Antibody (YA3344) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3344), targeting MTA2, with a predicted molecular weight of 75 kDa (observed band size: 75 kDa). MTA2 Antibody (YA3344) can be used for WB, IHC-P, ICC/IF, FC experiment in human background.

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MTA1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
MTA1 Human Pre-designed siRNA Set A contains three designed siRNAs for MTA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MTA2 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
MTA2 Human Pre-designed siRNA Set A contains three designed siRNAs for MTA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MTA3 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
MTA3 Human Pre-designed siRNA Set A contains three designed siRNAs for MTA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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