PRMT5-IN-34

Cat. No.: HY-158143: FAQs
Data Sheet Handling Instructions

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PRMT5-IN-34 (Compound C) is an inhibitor of MTA-cooperative Protein arginine methyltransferase 5 (PRMT5/MAT).

For research use only. We do not sell to patients.

PRMT5-IN-34 Chemical Structure

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•Related Small Molecules:

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View All Isoforms

EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

Biological Activity
Purity & Documentation
References
Customer Review

Description

PRMT5-IN-34 (Compound C) is an inhibitor of MTA-cooperative Protein arginine methyltransferase 5 (PRMT5/MAT)^[1].

IC₅₀ & Target^[1]

PRMT5

In Vitro

PRMT5-IN-34 inhibits each cell proliferation activity with IC₅₀=0.827 μM (HDLM2), 0.252 μM (L540), 0.077 μM (L1236), 4.638 μM (L428), 0.170 μM (HCT116), 8.538 μM (HCT116) and 0.538 μM (HCT116), respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PRMT5-IN-34 (p.o.; 25-100 mg/kg; once daily for 21 days) inhibits tumor growth and decreases SDMA protein levels in the MTAP-silenced L540HL xenograft mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	MTAP silenced L540 HL xenograft model ^[1]
Dosage:	25; 50; 100 mg/kg
Administration:	p.o. once daily for 21 days
Result:	Concentration-dependently inhibited tumor growth (22%, 52%, 93%). Concentration-dependently decreased the protein level of SDMA (83.9%, 97.6%, 99.1%).

Molecular Weight

435.43

Formula

C₂₃H₁₉F₂N₅O₂

SMILES

CC#CCN1CC[C@]2(C3=CC=C(C=C3C(N2CC4=CC5=C(N4)C=C(C(N)=N5)F)=O)F)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. James T et al. Methylthioadenosine (MTA)-cooperative protein arginine methyltransferase 5 (PRMT5) inhibitors for use in the treatment of cancer that is wild type MTAP gene silenced. World Intellectual Property Organization, WO2024038004 A1 2024-02-22

PRMT5-IN-34 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PRMT5-IN-34Histone Methyltransferasecancer L540 HL xenograft modelInhibitorinhibitorinhibit

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