MRTX-1719 hydrochloride

Cat. No.: HY-139611C Purity: 99.22%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

MRTX-1719 hydrochloride is a potent first-in-class selective inhibitor of the PRMT5/MTA complex, with an IC₅₀ of less than 10 nM in PRMT5/MTA MTAP^DEL SDMA cells.

For research use only. We do not sell to patients.

MRTX-1719 hydrochloride Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 860	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1160	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1920	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2700	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 3800	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of MRTX-1719 hydrochloride:

MRTX-1719 Get quote

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms

EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

Biological Activity
Purity & Documentation
References
Customer Review

Description

MRTX-1719 hydrochloride is a potent first-in-class selective inhibitor of the PRMT5/MTA complex, with an IC₅₀ of less than 10 nM in PRMT5/MTA MTAP^DEL SDMA cells^[1].

IC₅₀ & Target^[1]

PRMT5

Clinical Trial

Molecular Weight

501.34

Formula

C₂₃H₁₉Cl₂FN₆O₂

Appearance

Solid

Color

White to off-white

SMILES

[H]Cl.FC1=C(C=C(C(C#N)=[C@]1[C@]2=C(C3=CC=C4C(C(CN)=NNC4=O)=C3)C=NN2C)OC5CC5)Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (199.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9947 mL	9.9733 mL	19.9465 mL
5 mM	0.3989 mL	1.9947 mL	3.9893 mL
10 mM	0.1995 mL	0.9973 mL	1.9947 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.22%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (258 KB) HNMR (299 KB) LCMS (271 KB)

Handling Instructions (2659 KB)

References

[1]. Targeting the genetic and immunological drivers of cancer.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9947 mL	9.9733 mL	19.9465 mL	49.8664 mL
	5 mM	0.3989 mL	1.9947 mL	3.9893 mL	9.9733 mL
	10 mM	0.1995 mL	0.9973 mL	1.9947 mL	4.9866 mL
	15 mM	0.1330 mL	0.6649 mL	1.3298 mL	3.3244 mL
	20 mM	0.0997 mL	0.4987 mL	0.9973 mL	2.4933 mL
	25 mM	0.0798 mL	0.3989 mL	0.7979 mL	1.9947 mL
	30 mM	0.0665 mL	0.3324 mL	0.6649 mL	1.6622 mL
	40 mM	0.0499 mL	0.2493 mL	0.4987 mL	1.2467 mL
	50 mM	0.0399 mL	0.1995 mL	0.3989 mL	0.9973 mL
	60 mM	0.0332 mL	0.1662 mL	0.3324 mL	0.8311 mL
	80 mM	0.0249 mL	0.1247 mL	0.2493 mL	0.6233 mL
	100 mM	0.0199 mL	0.0997 mL	0.1995 mL	0.4987 mL