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Mycobacteria

" in MedChemExpress (MCE) Product Catalog:

46

Inhibitors & Agonists

1

Fluorescent Dye

7

Natural
Products

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0329
    Isoniazid
    4 Publications Verification

    INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide

    		 Bacterial Autophagy Mitophagy Antibiotic Infection
    Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity .
    Isoniazid
  • HY-B0901A
    Bromperidol hydrochloride
    2 Publications Verification

    R-11333 hydrochloride

    		 Dopamine Receptor Bacterial Neurological Disease
    Bromperidol (R-11333) hydrochloride possesses antipsychotic activity, with a high affinity for central dopamine receptors D2. Bromperidol hydrochloride can kill Mycobacteria in a synergistic manner with Spectinomycin .
    Bromperidol hydrochloride
  • HY-B0901
    Bromperidol
    2 Publications Verification

    R-11333

    		 Dopamine Receptor Bacterial Infection Neurological Disease
    Bromperidol (R-11333) possesses antipsychotic activity, with a high affinity for central dopamine receptors D2. Bromperidol can kill Mycobacteria in a synergistic manner with Spectinomycin .
    Bromperidol
  • HY-148478
    MMV688845

    (R)-GSK1729177A

    		 DNA/RNA Synthesis Infection
    MMV688845 is a nontuberculous mycobacteria (NTM) RNA polymerase inhibitor with bactericidal activity against Mycobacterium abscessus and anti-tuberculosis efficacy .
    MMV688845
  • HY-161135
    TBAJ-5307

    		Bacterial Infection
    TBAJ-5307 is a broad spectrum anti-non-tuberculous mycobacteria inhibitor that can target the FO-domain of the engine and preventing rotation and proton-translocation. TBAJ-5307 inhibits non-tuberculous mycobacteria in vitro and in vivo .
    TBAJ-5307
  • HY-135285
    Rifamexil

    		Antibiotic Bacterial Infection
    Rifamexil is an antibiotic Rifamycin (HY-B1907A) derivative that is active against Mycobacterium avium complex and other mycobacteria .
    Rifamexil
  • HY-B0329R
    Isoniazid (Standard)

    		Bacterial Autophagy Mitophagy Antibiotic Infection
    Isoniazid (Standard) is the analytical standard of Isoniazid. This product is intended for research and analytical applications. Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity .
    Isoniazid (Standard)
  • HY-146702
    MtTMPK-IN-8

    		Bacterial Thymidylate Synthase Infection
    MtTMPK-IN-8 (compound 27) is a moderate M. tuberculosis thymidylate kinase (MtbTMPK) inhibitor. MtTMPK-IN-8 has sub-micromolar activity against mycobacteria (MICs = 0.78~9.4 μM) without significant cytotoxicity. MtTMPK-IN-8 can be used for researching tuberculosis .
    MtTMPK-IN-8
  • HY-146703
    MtTMPK-IN-9

    		Bacterial Thymidylate Synthase Infection
    MtTMPK-IN-9 (compound 28) is a moderate M. tuberculosis thymidylate kinase (MtbTMPK) inhibitor with an IC50 value of 48 μM. MtTMPK-IN-9 has sub-micromolar activity against mycobacteria (MICs = 6.25~9.4 μM) without significant cytotoxicity. MtTMPK-IN-9 can be used for researching tuberculosis .
    MtTMPK-IN-9
  • HY-146701
    MtTMPK-IN-7

    		Bacterial Thymidylate Synthase Infection
    MtTMPK-IN-7 (compound 26) is a moderate M. tuberculosis thymidylate kinase (MtbTMPK) inhibitor with an IC50 value of 47 μM. MtTMPK-IN-7 has sub-micromolar activity against mycobacteria (MICs = 2.3~4.7 μM) without significant cytotoxicity. MtTMPK-IN-7 can be used for researching tuberculosis .
    MtTMPK-IN-7
  • HY-A0155
    Viomycin

    		Antibiotic Bacterial Cancer
    Viomycin is a potent antibiotic against Mycobacteria. Viomycin rapidly inhibits polypeptide chain elongation when added to purified endogenous Escherichia coli polysomes actively engaged in polypeptide synthesis .
    Viomycin
  • HY-145301
    Mycobactin-IN-1

    		Bacterial Infection
    Mycobactin-IN-1 (compound 44), a pyrazoline analogue, is a mycobactin biosynthesis inhibitor against mycobacteria. Mycobactin-IN-1 binds to salicyl-AMP ligase (MbtA), a key enzyme in the mycobactin biosynthetic pathway .
    Mycobactin-IN-1
  • HY-118481
    H-Pro-Glu-OH

    		Others Infection
    H-Pro-Glu-OH is a protein secreted by pathogenic mycobacteria through the Type VII secretion system. H-Pro-Glu-OH targets LipY lipases to the cell Surface via the ESX-5 Pathway .
    H-Pro-Glu-OH
  • HY-120733
    Calpinactam

    FKI-4905

    		 Bacterial Endogenous Metabolite Infection Inflammation/Immunology
    Calpinactam (FKI-4905), a fungal metabolite, is a new anti-mycobacterial agent.Calpinactam is active only against Mycobacteria among various microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibits the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 μg/ml, respectively .
    Calpinactam
  • HY-121136
    Chartreusin

    		Antibiotic Bacterial Infection
    Chartreusin is an antibiotic that is active against certain Gram-positive organisms and mycobacteria. Chartreusin is also active against the Micrococcus fiyogenes v. aureus phage .
    Chartreusin
  • HY-121136A
    Chartreusin sodium

    		Antibiotic Bacterial Infection
    Chartreusin sodium is an antibiotic that is active against certain Gram-positive organisms and mycobacteria. Chartreusin is also active against the Micrococcus fiyogenes v. aureus phage .
    Chartreusin sodium
  • HY-156359
    Tuberculosis inhibitor 10

    		Others Others
    Tuberculosis inhibitor 10 shows moderate inhibitory effect on the enzymatic activity of MSMEG_6649. Tuberculosis inhibitor 10 enhances the inhibitory activity of PAS against mycobacteria .
    Tuberculosis inhibitor 10
  • HY-D1543
    Pyronin B

    		DNA Stain Infection
    Pyronin B is an organic cationic dye used for the staining of bacteria, mycobacteria and ribonucleic acids. Pyronin B is also used as a small hydrophobic (SH) protein channel inhibitor .
    Pyronin B
  • HY-145302
    Mycobactin-IN-2

    		Bacterial Infection
    Mycobactin-IN-2 (compound 49) is a mycobactin biosynthesis inhibitor against mycobacteria. Mycobactin-IN-2 binds to salicyl-AMP ligase (MbtA), a key enzyme in the mycobactin biosynthetic pathway .
    Mycobactin-IN-2
  • HY-130511
    FCE 22250

    		Others Infection
    FCE 22250 is a 3-azinomethylrifamycin with long-term in vivo persistence and good oral absorption. FCE 22250 shows superior efficacy against a broad antimicrobial spectrum including mycobacteria .
    FCE 22250
  • HY-146699
    MtTMPK-IN-5

    		Bacterial Thymidylate Synthase Infection
    MtTMPK-IN-5 (compound 17) is a potent M. tuberculosis thymidylate kinase (MtbTMPK) inhibitor with an IC50 value of 34 μM. MtTMPK-IN-5 combines favorable enzyme inhibitory activity with significant activity against M. tuberculosis (MIC = 12.5 μM). MtTMPK-IN-5 can be used for researching tuberculosis .
    MtTMPK-IN-5
  • HY-146700
    MtTMPK-IN-6

    		Bacterial Thymidylate Synthase Infection
    MtTMPK-IN-6 (compound 1) is a potent M. tuberculosis thymidylate kinase (MtbTMPK) inhibitor with an IC50 value of 29 μM. MtTMPK-IN-6 can be used for researching tuberculosis .
    MtTMPK-IN-6
  • HY-W506116
    Ostruthin

    Ostruthine

    		 Bacterial Infection
    Ostruthin (Ostruthine) is an antimycobacterial coumarin, that can be isolated from the roots of Peucedanum ostruthium. Ostruthin causes a marked inhibition of the growth of gram-positive micro-organisms .
    Ostruthin
  • HY-10392
    Sutezolid
    4 Publications Verification

    PNU-100480; U-100480; PF-02341272

    		 Bacterial Antibiotic Infection
    Sutezolid (PNU-100480), an orally active oxazolidinone antimicrobial agent, acts by inhibiting bacterial protein synthesis. Sutezolid has potent activity against mycobacteria, and is used for the research of drug-resistant tuberculosis .
    Sutezolid
  • HY-122289
    Metioprim

    		Dihydrofolate reductase (DHFR) Bacterial Infection
    Metioprim is a competitive inhibitor of bacterial Dihydrofolate reductase (DHFR). Metioprim has inhibitory activity against anaerobic bacteria. Metioprim shows synergistic activity in combination with DDS (HY-B0688) against E. coli. and various mycobacteria .
    Metioprim
  • HY-B0329S
    Isoniazid-d4

    INH-d4; Isonicotinic acid hydrazide-d4; Isonicotinic hydrazide-d4

    		 Bacterial Autophagy Mitophagy Antibiotic Infection
    Isoniazid-d4 is the deuterium labeled Isoniazid. Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity[1][2][3][4].
    Isoniazid-d4
  • HY-B0901R
    Bromperidol (Standard)
    2 Publications Verification

    R-11333 (Standard)

    		 Dopamine Receptor Bacterial Infection Neurological Disease
    Bromperidol (Standard) is the analytical standard of Bromperidol. This product is intended for research and analytical applications. Bromperidol (R-11333) possesses antipsychotic activity, with a high affinity for central dopamine receptors D2. Bromperidol can kill Mycobacteria in a synergistic manner with Spectinomycin .
    Bromperidol (Standard)
  • HY-N1969
    3,3'-Di-O-methylellagic acid

    3,8-Di-O-methylellagic acid

    		 Bacterial Infection
    3,3'-Di-O-methylellagic acid obtained from Euphorbia adenochlora selectively inhibits the formation of acid-fastness in mycobacteria without retardation of their growth. 3,3'-di-O-methylellagic acid as a hepatoprotective compound is apparently due to its antioxidative effect .
    3,3'-Di-O-methylellagic acid
  • HY-162503
    ST166 free acid

    		Bacterial Infection
    ST166 free acid is a inhibitor of formation of the PhoP-DNA complex with the IC50 values of 18 and 24 μM against PhoP and MtrAC binding with DNA, respectively. ST166 free acid shows antibacterial activity against Macrobacterium marinum .
    ST166 free acid
  • HY-100725
    BM212
    3 Publications Verification

    		 Bacterial Infection
    BM212 is a potent Mycobacterial membrane protein Large 3 (MmpL3) inhibitor. BM212 has strong bactericidal activity against both M. tuberculosis and some nontuberculosis mycobacteria. BM212 exhibits antimycobacterial activity against M. tuberculosis H37Rv with an MIC of 5 µM .
    BM212
  • HY-144663
    MtTMPK-IN-1

    		Bacterial Thymidylate Synthase Infection
    MtTMPK-IN-1 (compound 3) is a potent Mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC50 value of 2.5 μM. MtTMPK-IN-1 has moderate to weak activity against Mtb H37Rv and low cytotoxicity in human fibroblast cells MRC-5. MtTMPK-IN-1 can be used for researching tuberculosis .
    MtTMPK-IN-1
  • HY-144664
    MtTMPK-IN-2

    		Bacterial Thymidylate Synthase Infection
    MtTMPK-IN-2 (compound 15) is a potent Mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC50 value of 1.1 μM. MtTMPK-IN-2 has inhibitory activity against Mtb H37Rv (MIC = 12.5 μM). MtTMPK-IN-2 exhibits certain cytotoxicity in human fibroblast cells MRC-5 (EC50 = 6.1 μM). MtTMPK-IN-2 can be used for researching tuberculosis .
    MtTMPK-IN-2
  • HY-144665
    MtTMPK-IN-3

    		Bacterial Thymidylate Synthase Infection
    MtTMPK-IN-3 (compound 25) is a potent Mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC50 value of 0.12 μM. MtTMPK-IN-3 has inhibitory activity against Mtb H37Rv (MIC = 12.5 μM). MtTMPK-IN-3 exhibits certain cytotoxicity in human fibroblast cells MRC-5 (EC50 = 12.5 μM). MtTMPK-IN-3 can be used for researching tuberculosis .
    MtTMPK-IN-3
  • HY-126117
    (+)-Xylariamide A

    		Fungal Carbonic Anhydrase Infection
    (+)-Xylariamide A (compound 6b) is a mycobacterial and fungal carbonic anhydrase probe with inhibitory activity against pathogen β-carbonic anhydrases .
    (+)-Xylariamide A
  • HY-162782A
    V–C6–Bg-PhCl TFA

    		Antibiotic Bacterial Infection
    V–C6–Bg-PhCl TFA (compound 5e) is a biguanide-vancomycin conjugate. V–C6–Bg-PhCl TFA has broad-spectrum antibacterial activity against both Gram-negative and Gram-positive bacteria .
    V–C6–Bg-PhCl TFA
  • HY-N10069
    Bonducellin

    		Others Infection
    Bonducellin is a a homoisoflavonoid, which can be isolated from Caesalpinia digyna roots. Bonducellin is a potent inhibitor of efflux pump (EP), while EP induces resistance in mycobacteria and serves as a target of anti-TB (tuberculosis) agents. Bonducellin reduces MIC of EtBr by 8-fold against M. smegmatis (MIC=62.5 mg/L) .
    Bonducellin
  • HY-B0509
    Amikacin hydrate
    Maximum Cited Publications
    11 Publications Verification

    BAY 41-6551 hydrate

    		 Bacterial Antibiotic Infection Cancer
    Amikacin hydrate (BAY 41-6551 hydrate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin hydrate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin hydrate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin hydrate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria .
    Amikacin hydrate
  • HY-B0509B
    Amikacin disulfate
    Maximum Cited Publications
    11 Publications Verification

    BAY 41-6551 disulfate

    		 Bacterial Antibiotic Infection Cancer
    Amikacin disulfate (BAY 41-6551 dissulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin disulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin disulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin disulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria .
    Amikacin disulfate
  • HY-107813
    Amikacin sulfate
    Maximum Cited Publications
    11 Publications Verification

    BAY 41-6551 sulfate

    		 Bacterial Antibiotic Infection Cancer
    Amikacin sulfate (BAY 41-6551 sulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin sulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin sulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin sulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria .
    Amikacin sulfate
  • HY-122292
    Celastramycin A

    		Antibiotic Bacterial Infection Inflammation/Immunology
    Celastramycin A is an antibiotic isolated from Streptomyces MaB-QuH-8, which exhibits antimicrobial activity against series of gram-negative bacteria and mycobacteria, with MICs between 0.05-3.1 μg/ml . Celastramycin A exhibits immunosuppressing efficacy in ex vivo Drosophila through immune deficiency pathway (IC50 of 0.008 μg/ml), inhibits the immunoresponse in human innate immunity through TNF-α signaling, inhibits IL-8 production in HUEVCs with IC50 of 0.06 μg/ml .
    Celastramycin A
  • HY-155639
    Tyramide alkyne
    1 Publications Verification

    		 Others Others
    Tyramide alkyne is an alternative labeling substrate that can be coupled to detection or enrichment moieties via a Copper-catalyzed Azide/Alkyne Cycloaddition (CuAAC) “click” reaction. Tyramide alkyne can be used for ascorbate peroxidase 2 (APEX2) labeling .
    Tyramide alkyne
  • HY-B0509BR
    Amikacin disulfate (Standard)

    		Bacterial Antibiotic Infection Cancer
    Amikacin (disulfate) (Standard) is the analytical standard of Amikacin (disulfate). This product is intended for research and analytical applications. Amikacin disulfate (BAY 41-6551 dissulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin disulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin disulfate is very active against most Gram-negative bacteria including gentamicin-and tobramycin-resistant strains. Amikacin disulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria .
    Amikacin disulfate (Standard)
  • HY-16566A
    Kanamycin sulfate
    Maximum Cited Publications
    11 Publications Verification

    Kanamycin A sulfate

    		 Bacterial Antibiotic Infection
    Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin sulfate shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia .
    Kanamycin sulfate
  • HY-16566
    Kanamycin
    Maximum Cited Publications
    11 Publications Verification

    Kanamycin A

    		 Antibiotic Bacterial Infection Inflammation/Immunology
    Kanamycin (Kanamycin A) is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia .
    Kanamycin
  • HY-105099
    Rifalazil

    KRM-1648; ABI-1648

    		 DNA/RNA Synthesis Bacterial Infection Inflammation/Immunology
    Rifalazil (KRM-1648; ABI-1648), a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase . Rifalazil (KRM-1648; ABI-1648) is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis with MIC values from 0.00025 to 0.0025 μg/ml . Rifalazil (KRM-1648; ABI-1648) has the potential for the treatment of Chlamydia infection, Clostridium difficile associated diarrhea (CDAD), and tuberculosis (TB) .
    Rifalazil
  • HY-157433
    Mab-SaS-IN-1

    		Bacterial Infection
    Mab-SaS-IN-1 (compoud 1H) is Mab-SaS inhibitor with the IC50 of 2 μM. Mab-SaS-IN-1 can be used for study of antibiosis by blocking iron uptake and metabolism .
    Mab-SaS-IN-1

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