Metioprim

Cat. No.: HY-122289: FAQs
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Metioprim is a competitive inhibitor of bacterial Dihydrofolate reductase (DHFR). Metioprim has inhibitory activity against anaerobic bacteria. Metioprim shows synergistic activity in combination with DDS (HY-B0688) against E. coli. and various mycobacteria.

For research use only. We do not sell to patients.

Metioprim Chemical Structure

CAS No. : 68902-57-8

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Description

In Vitro

Metioprim inhibits some anaerobic bacteria species with an average MIC value of 3.2 μg/mL^[1].
Metioprim (0-1.0 μM; 0-8 h) suppresses bacterial growth kinetics, and inhibits E. coli with an MIC value of 0.7 μg/mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Metioprim (5 mg/kg or 10 mg/kg; i.v.; single dose) has a shorter elimination half-life in goat than in pig (23 min vs 169 min), and its main metabolites are methionine sulfoxide and methoxysulfonic acid^[3].

Pharmacokinetic Analysis^[1]

Animal	Route	Dose (mg/kg)	C₀ (μg/mL)	A (μg/mL)	α (1/min)	t_1/2α (min)	B (μg/mL)	β (1/min)	t_1/2β (min)	V_C (1/kg)	V_p (1/kg)	V_d,ss (1/kg)	Cl_β (mL/min/kg)
Pigs	i.v.	5	3.6	2.1	0.032	25	1.5	0.00415	169	1.45	0.74	2.19	10.0
Goats	i.v.	10	12.2	6.4	0.220	4	5.6	0.03138	23	0.85	0.44	1.28	49

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

306.38

Formula

C₁₄H₁₈N₄O₂S

CAS No.

68902-57-8

SMILES

NC1=NC(N)=C(CC2=CC(OC)=C(C(OC)=C2)SC)C=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wüst J, et al. Activity of brodimoprim and metioprim alone and in combination with sulfonamides against anaerobic bacteria. Antimicrob Agents Chemother. 1983 Mar;23(3):490-2. [Content Brief]

[2]. Seydel JK, et al. Bacterial growth kinetics of Escherichia coli and mycobacteria in the presence of brodimoprim and metioprim alone and in combination with sulfamerazine and dapsone (VI). Chemotherapy. 1983;29(4):249-61. [Content Brief]

[3]. Nielsen P, et al. Pharmacokinetics and metabolism of metioprim in pigs and goats. Pharmacol Toxicol. 1987 Nov;61(5):330-4. [Content Brief]

Metioprim Related Classifications

Infection

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Metioprim68902-57-8Dihydrofolate reductase (DHFR)BacterialInhibitorinhibitorinhibit

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