2. Anti-infection
  3. Antibiotic Bacterial
  4. Celastramycin A

Celastramycin A is an antibiotic isolated from Streptomyces MaB-QuH-8, which exhibits antimicrobial activity against series of gram-negative bacteria and mycobacteria, with MICs between 0.05-3.1 μg/ml. Celastramycin A exhibits immunosuppressing efficacy in ex vivo Drosophila through immune deficiency pathway (IC50 of 0.008 μg/ml), inhibits the immunoresponse in human innate immunity through TNF-α signaling, inhibits IL-8 production in HUEVCs with IC50 of 0.06 μg/ml.

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Celastramycin A Chemical Structure

Celastramycin A Chemical Structure

CAS No. : 188988-62-7

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Celastramycin A Related Antibodies

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Description

Celastramycin A is an antibiotic isolated from Streptomyces MaB-QuH-8, which exhibits antimicrobial activity against series of gram-negative bacteria and mycobacteria, with MICs between 0.05-3.1 μg/ml[1]. Celastramycin A exhibits immunosuppressing efficacy in ex vivo Drosophila through immune deficiency pathway (IC50 of 0.008 μg/ml), inhibits the immunoresponse in human innate immunity through TNF-α signaling, inhibits IL-8 production in HUEVCs with IC50 of 0.06 μg/ml[2].

Molecular Weight

390.69

Formula

C17H18Cl3NO3
CAS No.
SMILES

O=C(C1=C(O)C(CCCCCC)=CC(Cl)=C1O)C2=CC(Cl)=C(Cl)N2
Structure Classification
Initial Source

Drosophila
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Celastramycin A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Celastramycin A188988-62-7AntibioticBacterialDrosophilaantimicrobialHUVECStreptomycesInhibitorinhibitorinhibit

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