Search Result

Results for "

NPC

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (1) Akt (1) Amino Acid Derivatives (1) Apoptosis (9) ATM/ATR (2) Autophagy (8) Bacterial (2) Beta-lactamase (1) Bradykinin Receptor (2) Casein Kinase (2) Caspase (1) CDK (2) CMV (1) DNA-PK (2) Drug Metabolite (3) EGFR (1) Ephrin Receptor (1) ERK (1) Fatty Acid Synthase (FASN) (1) Filovirus (2) GLUT (1) HDAC (3) Histone Methyltransferase (3) Influenza Virus (1) Isotope-Labeled Compounds (3) JNK (1) Keap1-Nrf2 (7) Liposome (2) mTOR (1) p38 MAPK (1) PD-1/PD-L1 (1) Phosphatase (1) PI3K (3) PKC (1) PPAR (2) PROTAC Linkers (1) Small Interfering RNA (siRNA) (3) Sodium Channel (2) STAT (3)
By Research Areas:	Cancer (28) Cardiovascular Disease (8) Infection (8) Inflammation/Immunology (3) Metabolic Disease (4) Neurological Disease (9)
Oligonucleotides:	Pre-designed siRNA Sets (3) Cationic Lipids (1) siRNAs (3)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99621

Fiztasovimab NPC-21; EV2038	CMV	Infection
Fiztasovimab (NPC-21; EV2038) is a fully human IgG1λ mAb against human cytomegalovirus (hCMV). Fiztasovimab acts neutralizing activity by binding to the antigenic domain 1 of glycoprotein B on hCMV envelope. Fiztasovimab inhibits cell-to-cell transmission of hCMV .

HY-100638A

RPR132595A hydrochloride NPC hydrochloride	Drug Metabolite	Cancer
RPR132595A (NPC) hydrochloride is an active metabolite of CPT-11, which is generated by cytochrome P-450 3A4 (CYP3A4) and finally excreted through urine .

HY-100638

RPR132595A NPC	Drug Metabolite	Cancer
RPR132595A (NPC) is an active metabolite of CPT-11, which is generated by cytochrome P-450 3A4 (CYP3A4) and finally excreted through urine .

HY-P2118

NPC-567	Bradykinin Receptor	Inflammation/Immunology
NPC-567 is a bradykinin B2 receptor antagonist. NPC-567 is effective in inhibiting the acute response to allergen in the airways .

HY-129980

NPC-15437 dihydrochloride	PKC	Neurological Disease
NPC-15437 dihydrochloride is a selective, penetrable and reversible protein kinase C (PKC) inhibitor, with an IC₅₀ of 19 μM. NPC-15437 dihydrochloride interferes with mechanisms underlying memory consolidation .

HY-P1721

NPC 17731	Bradykinin Receptor	Cardiovascular Disease
NPC 17731 is a new bradykinin (BK) receptor antagonist. NPC 17731 antagonized both the contractile and relaxant responses caused by BK in longitudinal smooth muscle with IC₅₀ of 23 and 29 nM, respectively .

HY-100961

NPC 200 1,3-Dipropyl-8-phenylxanthine	Adenosine Receptor	Inflammation/Immunology
NPC 200 is a potent and selective antagonist of Adenosine A1 Receptor. NPC 200 reverses NECA-induced left and right atrial depression with EC₅₀s of 1.08 and 2.03 μM .

HY-RS09474

NPC1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NPC1 Human Pre-designed siRNA Set A contains three designed siRNAs for NPC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NPC1 Human Pre-designed siRNA Set A NPC1 Human Pre-designed siRNA Set A

HY-RS09476

NPC2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NPC2 Human Pre-designed siRNA Set A contains three designed siRNAs for NPC2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NPC2 Human Pre-designed siRNA Set A NPC2 Human Pre-designed siRNA Set A

HY-RS09475

NPC1L1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NPC1L1 Human Pre-designed siRNA Set A contains three designed siRNAs for NPC1L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NPC1L1 Human Pre-designed siRNA Set A NPC1L1 Human Pre-designed siRNA Set A

HY-101064

Fmoc-leucine N-FMOC-leucine; NPC 15199; NSC 334290	PPAR	Metabolic Disease
Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity .

HY-Y1250

Fmoc-Gly-OH Fmoc glycine; N-(9-Fluorenylmethoxycarbonyl)glycine; N-Fluorenylmethoxycarbonylglycine; NPC 14692; NSC 334288; [[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]acetic acid	Amino Acid Derivatives	Others
Fmoc-Gly-OH (Fmoc glycine) is a Fmoc-protected glycine derivative, can be used for the synthesis of compounds .

HY-101064S2

Fmoc-leucine-d3 N-FMOC-leucine-d₃; NPC 15199-d₃; NSC 334290-d₃	PPAR	Metabolic Disease
Fmoc-leucine-d₃ is the deuterium labeled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity[1].

HY-Y1250S6

Fmoc-Gly-OH-13C2,15N Fmoc glycine-¹³C₂,¹⁵N; N-(9-Fluorenylmethoxycarbonyl)glycine-¹³C₂,¹⁵N; N-Fluorenylmethoxycarbonylglycine-¹³C₂,¹⁵N; NPC 14692-¹³C₂-¹⁵N; NSC 334288-¹³C₂,¹⁵N; [[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]acetic acid-¹³C₂,¹⁵N	Isotope-Labeled Compounds Influenza Virus Bacterial	Infection
Fmoc-Gly-OH- ¹³C₂, ¹⁵N is a ¹⁵N-labeled and ¹³C-labled Crystal Violet. Crystal violet (Basic Violet 3) is a triarylmethane dye. Crystal Violet (Gentian Violet) has antiviral effects against H1N1 and also has prominent bactericidal activities.

HY-140694

*m-PEG-NPC* (MW 20000)**	PROTAC Linkers	Cancer
m-PEG-NPC (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-113845

(+)-Intermedine	Others	Neurological Disease
(+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs) .

HY-16459

Glycididazole sodium Sodium glycididazole	Apoptosis	Cancer
Glycididazole sodium (Sodium glycididazole) is a radiosensitizer. Glycididazole sodium increases the sensitivity of nasopharyngeal carcinoma cells to radiation, through increaased DNA damage and enhanced apoptosis in NPC cells

HY-137135

Cantharidic acid	Phosphatase Apoptosis ERK p38 MAPK JNK	Cancer
Cantharidic acid is a selective inhibitor for protein phosphatase 2 (PP2A) and protein phosphatase 1 (PP1). Cantharidic acid inhibits cell viability and arrest cell cycle at sub G1 phase, induces apoptosis in cells NPC-39 and HONE-1 through the upregulation of ERK1/2, p38, and JNK1/2 pathway .

HY-P10412

A11 ANXA1-derived 11 amino acid–long peptide	Ephrin Receptor	Cancer
A11 (ANXA1-derived 11 amino acid–long peptide) is an ANXA1-EphA2 interaction blocker peptide. A11 decreases ANXA1 bound to EphA2 and increased Cbl (an E3 ubiquitin ligase of EphA2) bound to EphA2. A11 efficiently decreases EphA2 level, and substantially increases EphA2 ubiquitination. A11 increases EphA2 internalization and colocalization of EphA2 and Cbl in the NPC cells. A11 inhibits nasopharyngeal carcinoma (NPC) cell proliferation, migration and invasion. A11 inhibits angiogenesis .

HY-113845R

(+)-Intermedine (Standard)	Others	Neurological Disease
(+)-Intermedine (Standard) is the analytical standard of (+)-Intermedine. This product is intended for research and analytical applications. (+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs) .

HY-P99544

Tagitanlimab HBM-9167; KL-A167	PD-1/PD-L1	Cancer
Tagitanlimab (HBM-9167) is a humanized anti-PD-L1 antibody (IgG1κ type). Tagitanlimab selectively blocks the interaction of PD-L1 and PD-1. Tagitanlimab has the potential to be studied in recurrent or metastatic nasopharyngeal carcinoma (NPC) .

HY-116815

Lalistat 1	Beta-lactamase Bacterial	Infection Neurological Disease
Lalistat 1 is a potent, selective, and competitive inhibitor of lysosomal acid lipase (LAL) and against purified human LAL (phLAL) with an IC₅₀ of 68 nM. Lalistat 1 is a inhibitor of immunoglobulin A1 protease (IgA1P) proteases for H. influenzae, has less effects on other serine hydrolases (trypsin or β-lactamase, etc.). Lalistat 1 can be used for the research of niemann-pick type C (NPC) disease .

HY-N6842

ArnicolideC	Others	Infection Cancer
ArnicolideC is a sesquiterpene lactone isolated Centipeda minima . ArnicolideC exertes a cytotoxic effect on the panel of Nasopharyngeal carcinoma (NPC) cells, significantly inhibiting cell growth in a dose- and time- dependent manner. ArnicolideC also exhibits inhibitory effects on NPC proliferation .

HY-120429

SKLB-163	Apoptosis	Cancer
SKLB-163 is an orally active inhibitor for Rho GDP-dissociation (RhoGDI). SKLB-163 inhibits highly expressed RhoGDI tumor cell proliferation and migration, and increases radiosensitivity of tumor cells. SKLB-163 induces cancer cell Apoptosis .

HY-D2314

Cyanine 7-amine chloride hydrochloride	Liposome	Others
Cyanine 7-amine (chloride hydrochloride) can be used to label cationic nanoparticles (NPs) or to NP conjugates (NPCs). It can track the residence time and clearance of nanoparticles in the body .

HY-103641C

Octyl-α-hydroxyglutarate Octyl-2-HG	Histone Methyltransferase	Cancer
Octyl-α-hydroxyglutarate (octyl-2-HG) increases histone methylation and enhances viability of LMP1-negative NPC cells .

HY-N2292

Kinsenoside 1 Publications Verification	Keap1-Nrf2 Apoptosis	Inflammation/Immunology
Kinsenoside is the main active ingredient of the genus plant, and has various biological activities. Kinsenoside and Nrf2 depend on the protection of nuclear cells (NPCs), which significantly reduces their ability to survive. Kinsenoside Active NPC Medium AKT-ERK1/2-Nrf2 Signal passage, Prevent physical decline, aging, harmonious physical function impairment. Kinsenoside can improve the puncture guide model for intermediate vertebral wall discharge (IDD).

HY-10996

KHS101	Others	Neurological Disease
KHS101 is a small molecule that accelerates neuronal differentiation. KHS101 can distributes to the brain and resulted in a significant increase in neuronal differentiation .

HY-17376

Ezetimibe 5+ Cited Publications SCH 58235	Keap1-Nrf2 Autophagy	Cardiovascular Disease Cancer
Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-17376S

Ezetimibe-d4 SCH 58235-d₄	Autophagy Keap1-Nrf2 Isotope-Labeled Compounds	Cardiovascular Disease Cancer
Ezetimibe-d₄ is the deuterium labeled Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-17640

Nicodicosapent	Fatty Acid Synthase (FASN) Autophagy	Metabolic Disease
Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.

HY-136433

N,N'-Dinitrosopiperazine 1,4-Dinitrosopiperazine; DNP	Others	Cancer
N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568 .

HY-160880

EBOV-IN-5	Others	Infection
EBOV-IN-5 (compound 14) is an antiviral agent that inhibits Ebola virus (EBOV) infection. EBOV-IN-5 inhibits the binding of the EBOV glycoprotein EBOV-GPcl to NPC1, an indispensable host receptor required for viral fusion/entry .

HY-135388

ent-Ezetimibe ent-SCH 58235	Drug Metabolite	Cardiovascular Disease
ent-Ezetimibe (ent-SCH 58235) is the RRS-enantiomer of Ezetimibe. Ezetimibe is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator .

HY-136059

Desfluoro-ezetimibe	Keap1-Nrf2 Autophagy	Cardiovascular Disease Cancer
Desfluoro-ezetimibe is a desfluoro impurity of Ezetimibe. Ezetimibe is a potent, metabolically stable cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator .

HY-17376S1

Ezetimibe-d4-1 SCH 58235-d₄-1	Keap1-Nrf2 Autophagy	Cardiovascular Disease Cancer
Ezetimibe-d₄-1 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-133114

Ezetimibe ketone EZM-K	Keap1-Nrf2 Autophagy	Cardiovascular Disease Cancer
Ezetimibe ketone (EZM-K) is a phase-I metabolite of Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor .

HY-160882

EBOV-IN-7	Filovirus	Infection
EBOV-IN-7 (compound 26) is an inhibitor of the Ebola virus EBOV with an IC₅₀ of 2.04 μM against EBOV-GP pseudotyped virus (pEBOV). EBOV-IN-7 has inhibitory effects on cancer cells and inhibits the EBOV-GPcl/NPC1 interaction .

HY-17376R

Ezetimibe (Standard) 5+ Cited Publications SCH 58235 (Standard)	Keap1-Nrf2 Autophagy	Cardiovascular Disease Cancer
Ezetimibe (Standard) is the analytical standard of Ezetimibe. This product is intended for research and analytical applications. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-160581

OH-C-Chol	Liposome	Others
OH-C-Chol is a cationic liposome that serves as a siRNA delivery vehicle. OH-C-Chol (LP-C) and OH-NC-Chol (LP-NC)/siRNA complexes (lipoplexes) showed better performance than NP-C and NP-NC/siRNA complexes (nanocomplexes), respectively. ) greater gene silencing effect .

HY-136433S

N,N'-Dinitrosopiperazine-d8 1,4-Dinitrosopiperazine-d₈; DNP-d₈	Isotope-Labeled Compounds	Cancer
N,N'-Dinitrosopiperazine-d₈ is the deuterium labeled N,N'-Dinitrosopiperazine[1]. N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine;DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568[2].

HY-N6843

Arnicolide D 1 Publications Verification	Caspase PI3K Akt mTOR STAT	Cancer
Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner .

HY-W395779

EBOV-IN-1	Filovirus	Infection
EBOV-IN-1 (com 3.47) is an adamantane dipeptide piperazine and an inhibitor of Ebola virus (EBOV). EBOV-IN-1 targets Niemann-Pick C1 (NPC1) and inhibits its binding to the EBOV glycoprotein (GP) that activates and mediates viral penetration into host cells, thereby inhibiting EBOV infection. EBOV-IN-1 inhibits pseudotyped EBOV infection with an IC50 of 13 nM .

HY-121315

BRD4097	HDAC	Metabolic Disease
BRD4097 is an inhibitor of histone deacetylase (HDAC). BRD4097 acts by inhibiting the activity of HDACs, especially HDAC 1,2 and 3, through metal chelation and spatial rejection mechanisms, and this inhibition may help regulate gene expression and alter chromatin structure, thereby affecting a variety of biological processes. BRD4097 is used to study the role of HDAC in cholesterol metabolism and NPC1 diseases .

HY-117583

cis-BG47	HDAC Histone Methyltransferase	Neurological Disease
cis-BG47 is an cis-isomer of BG47, BG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. BG47 can bind to and competitively inhibits the deacetylase activity of HDAC targets upon a light-induced trans-to-cis isomerization, and increases Histone Methyltransferase H3K9 acetylation. cis-BG47 can be used for neurological disease research .

HY-117583A

BG47	HDAC Histone Methyltransferase	Neurological Disease
BG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. BG47 can bind to and competitively inhibits the deacetylase activity of HDAC targets upon a light-induced trans-to-cis isomerization, and increases Histone Methyltransferase H3K9 acetylation. BG47 can be used for neurological disease research .

HY-P1411

Psalmotoxin 1 1 Publications Verification PcTx1; Psalmopoeus cambridgei toxin-1	Sodium Channel Apoptosis	Neurological Disease Cancer
Psalmotoxin 1 (PcTx1) is a protein toxin that can bind at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). Psalmotoxin 1 is a potent and slective ASIC1a inhibitor (IC₅₀: 0.9 nM) by increasing the apparent affinity for H ⁺ of ASIC1a. Psalmotoxin 1 can induce cell apoptosis, also inhibits cell migration, proferliration and invasion of cancer cells. Psalmotoxin 1 can be used in the research of cancers, or neurological disease .

HY-P1411A

Psalmotoxin 1 TFA 1 Publications Verification PcTx1 TFA; Psalmopoeus cambridgei toxin-1 TFA	Sodium Channel Apoptosis	Neurological Disease Cancer
Psalmotoxin 1 (PcTx1) TFA is a protein toxin that can bind at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). Psalmotoxin 1 TFA is a potent and slective ASIC1a inhibitor (IC₅₀: 0.9 nM) by increasing the apparent affinity for H ⁺ of ASIC1a. Psalmotoxin 1 TFA can induce cell apoptosis, also inhibits cell migration, proferliration and invasion of cancer cells. Psalmotoxin 1 TFA can be used in the research of cancers, or neurological disease .

HY-163726

GLUT1/EGFR-IN-1	GLUT EGFR Apoptosis	Cancer
GLUT1/EGFR-IN-1 (compound H) is a potent inhibitor of GLUT1 and EGFR. GLUT1/EGFR-IN-1 can simultaneously act on the EGFR tyrosine kinase ATP-binding site and inhibit GLUT1-mediated energy metabolism, resulting in reductions in ATP, MMP, intra-cellular lactic acid, and EGFR nuclear transfer. GLUT1/EGFR-IN-1 can be used for nasopharyngeal carcinoma (NPC) and triple-negative breast cancer (TNBC) research .

HY-N6954

Garcinone C 1 Publications Verification	ATM/ATR STAT CDK	Cancer
Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while efficiently inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, cdc2, Stat3 and CDK7. Garcinone C significantly inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner .

Cat. No.	Product Name	Type

HY-D2314

Cyanine 7-amine chloride hydrochloride	Dyes
Cyanine 7-amine (chloride hydrochloride) can be used to label cationic nanoparticles (NPs) or to NP conjugates (NPCs). It can track the residence time and clearance of nanoparticles in the body .

Cat. No.	Product Name	Target	Research Area

HY-Y1250

Fmoc-Gly-OH Fmoc glycine; N-(9-Fluorenylmethoxycarbonyl)glycine; N-Fluorenylmethoxycarbonylglycine; NPC 14692; NSC 334288; [[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]acetic acid	Amino Acid Derivatives	Others
Fmoc-Gly-OH (Fmoc glycine) is a Fmoc-protected glycine derivative, can be used for the synthesis of compounds .

HY-P1411

Psalmotoxin 1 1 Publications Verification PcTx1; Psalmopoeus cambridgei toxin-1	Sodium Channel Apoptosis	Neurological Disease Cancer
Psalmotoxin 1 (PcTx1) is a protein toxin that can bind at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). Psalmotoxin 1 is a potent and slective ASIC1a inhibitor (IC₅₀: 0.9 nM) by increasing the apparent affinity for H ⁺ of ASIC1a. Psalmotoxin 1 can induce cell apoptosis, also inhibits cell migration, proferliration and invasion of cancer cells. Psalmotoxin 1 can be used in the research of cancers, or neurological disease .

HY-P1411A

Psalmotoxin 1 TFA 1 Publications Verification PcTx1 TFA; Psalmopoeus cambridgei toxin-1 TFA	Sodium Channel Apoptosis	Neurological Disease Cancer
Psalmotoxin 1 (PcTx1) TFA is a protein toxin that can bind at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). Psalmotoxin 1 TFA is a potent and slective ASIC1a inhibitor (IC₅₀: 0.9 nM) by increasing the apparent affinity for H ⁺ of ASIC1a. Psalmotoxin 1 TFA can induce cell apoptosis, also inhibits cell migration, proferliration and invasion of cancer cells. Psalmotoxin 1 TFA can be used in the research of cancers, or neurological disease .

HY-P2118

NPC-567	Bradykinin Receptor	Inflammation/Immunology
NPC-567 is a bradykinin B2 receptor antagonist. NPC-567 is effective in inhibiting the acute response to allergen in the airways .

HY-P1721

NPC 17731	Bradykinin Receptor	Cardiovascular Disease
NPC 17731 is a new bradykinin (BK) receptor antagonist. NPC 17731 antagonized both the contractile and relaxant responses caused by BK in longitudinal smooth muscle with IC₅₀ of 23 and 29 nM, respectively .

HY-P10412

A11 ANXA1-derived 11 amino acid–long peptide	Ephrin Receptor	Cancer
A11 (ANXA1-derived 11 amino acid–long peptide) is an ANXA1-EphA2 interaction blocker peptide. A11 decreases ANXA1 bound to EphA2 and increased Cbl (an E3 ubiquitin ligase of EphA2) bound to EphA2. A11 efficiently decreases EphA2 level, and substantially increases EphA2 ubiquitination. A11 increases EphA2 internalization and colocalization of EphA2 and Cbl in the NPC cells. A11 inhibits nasopharyngeal carcinoma (NPC) cell proliferation, migration and invasion. A11 inhibits angiogenesis .

HY-P1730

Nuclear pore complex protein Nup98 (315-360)	Peptides	Cancer
Nuclear pore complex protein Nup98 (315-360) is the 315-360 fragment part of the nuclear pore complex (NPC) protein .

Cat. No.	Product Name	Target	Research Area

HY-P99621

Fiztasovimab NPC-21; EV2038	CMV	Infection
Fiztasovimab (NPC-21; EV2038) is a fully human IgG1λ mAb against human cytomegalovirus (hCMV). Fiztasovimab acts neutralizing activity by binding to the antigenic domain 1 of glycoprotein B on hCMV envelope. Fiztasovimab inhibits cell-to-cell transmission of hCMV .

HY-P99544

Tagitanlimab HBM-9167; KL-A167	PD-1/PD-L1	Cancer
Tagitanlimab (HBM-9167) is a humanized anti-PD-L1 antibody (IgG1κ type). Tagitanlimab selectively blocks the interaction of PD-L1 and PD-1. Tagitanlimab has the potential to be studied in recurrent or metastatic nasopharyngeal carcinoma (NPC) .

HY-P99362

Ensituximab Anti-MUC5AC Reference Antibody (ensituximab); NEO-102	Inhibitory Antibodies	Cancer
Ensituximab (NEO-102; NPC-1C) is a chimeric monoclonal IgG1 antibody targeting a variant of MUC5AC. Ensituximab shows specificity to colorectal and pancreatic cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113845

(+)-Intermedine	Alkaloids Pyrrole Alkaloids Source classification Plants Symphytum officinale L. Boraginaceae	Others
(+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs) .

HY-P99544

Tagitanlimab HBM-9167; KL-A167	Classification of Application Fields Disease Research Fields Cancer	PD-1/PD-L1
Tagitanlimab (HBM-9167) is a humanized anti-PD-L1 antibody (IgG1κ type). Tagitanlimab selectively blocks the interaction of PD-L1 and PD-1. Tagitanlimab has the potential to be studied in recurrent or metastatic nasopharyngeal carcinoma (NPC) .

HY-N6842

ArnicolideC	Infection Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Euchresta horsfieldii (Lesch.) J. Benn. Source classification Plants Compositae Disease Research Fields Cancer	Others
ArnicolideC is a sesquiterpene lactone isolated Centipeda minima . ArnicolideC exertes a cytotoxic effect on the panel of Nasopharyngeal carcinoma (NPC) cells, significantly inhibiting cell growth in a dose- and time- dependent manner. ArnicolideC also exhibits inhibitory effects on NPC proliferation .

HY-N2292

Kinsenoside 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Orchidaceae Plants Anoectochilus Inflammation/Immunology Disease Research Fields	Keap1-Nrf2 Apoptosis
Kinsenoside is the main active ingredient of the genus plant, and has various biological activities. Kinsenoside and Nrf2 depend on the protection of nuclear cells (NPCs), which significantly reduces their ability to survive. Kinsenoside Active NPC Medium AKT-ERK1/2-Nrf2 Signal passage, Prevent physical decline, aging, harmonious physical function impairment. Kinsenoside can improve the puncture guide model for intermediate vertebral wall discharge (IDD).

HY-N6843

Arnicolide D 1 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Euchresta horsfieldii (Lesch.) J. Benn. Source classification Plants Compositae Disease Research Fields Cancer	Caspase PI3K Akt mTOR STAT
Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner .

HY-N6954

Garcinone C 1 Publications Verification	Structural Classification other families Xanthones Classification of Application Fields Garcinia oblongifolia Champ. ex Benth. Guttiferae Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	ATM/ATR STAT CDK
Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while efficiently inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, cdc2, Stat3 and CDK7. Garcinone C significantly inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner .

HY-113845R

(+)-Intermedine (Standard)	Structural Classification Alkaloids Pyrrole Alkaloids Source classification Symphytum officinale L. Plants Boraginaceae	Others
(+)-Intermedine (Standard) is the analytical standard of (+)-Intermedine. This product is intended for research and analytical applications. (+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs) .

HY-N6954R

Garcinone C (Standard)	Structural Classification other families Xanthones Garcinia oblongifolia Champ. ex Benth. Guttiferae Source classification Phenols Polyphenols Plants	ATM/ATR STAT CDK
Garcinone C (Standard) is the analytical standard of Garcinone C. This product is intended for research and analytical applications. Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while efficiently inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, cdc2, Stat3 and CDK7. Garcinone C significantly inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time? and dose?dependent manner .

Species:	Human (2) Rat (1) Mouse (1) Cynomolgus (1)
Tag:	His (5)
Source:	HEK293 (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P74695

	*Niemann Pick C1/NPC1 Protein, Human (His)* NPC intracellular cholesterol transporter 1; Niemann-Pick C1 protein; NPC1	Human	HEK293
	The Niemann Pick C1/NPC1 protein is an intracellular cholesterol transporter that cooperates with NPC2 to promote cholesterol efflux from the endosomal/lysosomal compartment. NPC2 transfers unesterified cholesterol to the N-terminal domain of NPC1, where the cholesterol is bound in a hydrophobic pocket. Niemann Pick C1/NPC1 Protein, Human (His-Flag) is the recombinant human-derived Niemann Pick C1/NPC1 protein, expressed by HEK293 , with N-His labeled tag. The total length of Niemann Pick C1/NPC1 Protein, Human (His-Flag) is 251 a.a., with molecular weight of ~38-55 kDa.

HY-P74692

	*Niemann Pick C2/NPC2 Protein, Rat (HEK293, His)* NPC intracellular cholesterol transporter 2; Niemann-Pick disease type C2 protein; HE1	Rat	HEK293
	Niemann-Pick C2/NPC2 protein is an important member of the NPC2 family and plays an important role in lipid metabolism and transport, helping to regulate intracellular cholesterol homeostasis and lipid transport.Its involvement in cellular processes highlights its importance in maintaining lipid homeostasis.Niemann Pick C2/NPC2 Protein, Rat (HEK293, His) is the recombinant rat-derived Niemann Pick C2/NPC2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P74693

	*Niemann Pick C2/NPC2 Protein, Mouse (HEK293, His)* NPC intracellular cholesterol transporter 2; Niemann-Pick disease type C2 protein; HE1	Mouse	HEK293
	Niemann Pick C2/NPC2 Protein, a lysosomal protein, plays a critical role in cholesterol trafficking and lipid metabolism. It facilitates the transport of cholesterol from lysosomes to other cellular compartments. Understanding the functions of NPC2 Protein is vital for studying lipid disorders and developing therapeutic strategies targeting abnormal cholesterol metabolism. Niemann Pick C2/NPC2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Niemann Pick C2/NPC2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Niemann Pick C2/NPC2 Protein, Mouse (HEK293, His) is 130 a.a., with molecular weight of ~15.9-19 kDa.

HY-P74694

	*Niemann Pick C2/NPC2 Protein, Human (HEK293, His)* NPC intracellular cholesterol transporter 2; Niemann-Pick disease type C2 protein; HE1	Human	HEK293
	The Niemann Pick C2/NPC2 Protein is a crucial lysosomal protein that regulates cholesterol trafficking and lipid metabolism. It enables the movement of cholesterol from lysosomes to other parts of the cell. Studying the functions of NPC2 Protein is essential for understanding lipid disorders and developing treatments targeting disrupted cholesterol metabolism. Niemann Pick C2/NPC2 Protein, Human (HEK293, His) is the recombinant human-derived Niemann Pick C2/NPC2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P700667

	BST2 Protein, Cynomolgus (HEK293, His) BST-2; HM1.24 antigen; CD317; BST2; NPC-A-7; PDCA-1; TETHERIN	Cynomolgus	HEK293
	The BST2 protein is an IFN-induced antiviral factor that inhibits mammalian enveloped viruses by tethering viral particles to infected cell membranes. BST2 acts as a physical tether connecting virions, limiting their release and spread. BST2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived BST2 protein, expressed by HEK293 , with N-His labeled tag. The total length of BST2 Protein, Cynomolgus (HEK293, His) is 115 a.a., with molecular weight of 15-30 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-101064S2

Fmoc-leucine-d3
Fmoc-leucine-d₃ is the deuterium labeled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity[1].

HY-17376S

Ezetimibe-d4
Ezetimibe-d₄ is the deuterium labeled Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-17376S1

Ezetimibe-d4-1
Ezetimibe-d₄-1 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-Y1250S6

Fmoc-Gly-OH-13C2,15N
Fmoc-Gly-OH- ¹³C₂, ¹⁵N is a ¹⁵N-labeled and ¹³C-labled Crystal Violet. Crystal violet (Basic Violet 3) is a triarylmethane dye. Crystal Violet (Gentian Violet) has antiviral effects against H1N1 and also has prominent bactericidal activities.

HY-136433S

N,N'-Dinitrosopiperazine-d8
N,N'-Dinitrosopiperazine-d₈ is the deuterium labeled N,N'-Dinitrosopiperazine[1]. N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine;DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568[2].

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HY-P82545

	Niemann Pick C1 Antibody (YA2290) Niemann Pick C1 protein precursor; NPC; NPC1	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Niemann Pick C1 Antibody (YA2290) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2290), targeting Niemann Pick C1, with a predicted molecular weight of 142 kDa (observed band size: 180 kDa). Niemann Pick C1 Antibody (YA2290) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

HY-P81911

	Niemann Pick C1 Like 1 Antibody (YA1656) NPC1 LIKE 1; NPC1L1	WB	Human
	Niemann Pick C1 Like 1 Antibody (YA1656) is a biotin-conjugated non-conjugated IgG antibody, targeting Niemann Pick C1 Like 1, with a predicted molecular weight of 149 kDa. Niemann Pick C1 Like 1 Antibody (YA1656) can be used for WB experiment in human background.

HY-P83612

	BST2 Antibody (YA3357) Bone marrow stromal antigen 2; BST2; CD317; HM1.24 antigen; NPC A 7; Tetherin	WB, IHC-P, FC	Human
	BST2 Antibody (YA3357) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3357), targeting BST2, with a predicted molecular weight of 20 kDa (observed band size: 28-40 kDa). BST2 Antibody (YA3357) can be used for WB, IHC-P, FC experiment in human background.

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Cat. No.	Product Name		Classification

HY-RS09474

NPC1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
NPC1 Human Pre-designed siRNA Set A contains three designed siRNAs for NPC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS09476

NPC2 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
NPC2 Human Pre-designed siRNA Set A contains three designed siRNAs for NPC2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS09475

NPC1L1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
NPC1L1 Human Pre-designed siRNA Set A contains three designed siRNAs for NPC1L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-160581

OH-C-Chol		Cationic Lipids
OH-C-Chol is a cationic liposome that serves as a siRNA delivery vehicle. OH-C-Chol (LP-C) and OH-NC-Chol (LP-NC)/siRNA complexes (lipoplexes) showed better performance than NP-C and NP-NC/siRNA complexes (nanocomplexes), respectively. ) greater gene silencing effect .

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