2. Metabolic Enzyme/Protease Apoptosis Stem Cell/Wnt MAPK/ERK Pathway
  3. Phosphatase Apoptosis ERK p38 MAPK JNK
  4. Cantharidic acid

Cantharidic acid is a selective inhibitor for protein phosphatase 2 (PP2A) and protein phosphatase 1 (PP1). Cantharidic acid inhibits cell viability and arrest cell cycle at sub G1 phase, induces apoptosis in cells NPC-39 and HONE-1 through the upregulation of ERK1/2, p38, and JNK1/2 pathway.

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Cantharidic acid Chemical Structure

Cantharidic acid Chemical Structure

CAS No. : 28874-45-5

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Other Forms of Cantharidic acid:

Cantharidic acid Related Antibodies

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Description

Cantharidic acid is a selective inhibitor for protein phosphatase 2 (PP2A) and protein phosphatase 1 (PP1). Cantharidic acid inhibits cell viability and arrest cell cycle at sub G1 phase, induces apoptosis in cells NPC-39 and HONE-1 through the upregulation of ERK1/2, p38, and JNK1/2 pathway[1].

Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
218.5 μM
Compound: 4
Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 33454654]
HL-60 IC50
103.2 μM
Compound: 4
Anticancer activity against human HL-60 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Anticancer activity against human HL-60 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 33454654]
KB 3-1 IC50
79.2 μM
Compound: 4
Anticancer activity against human KB 3-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Anticancer activity against human KB 3-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 33454654]
Molecular Weight

214.22

Formula

C10H14O5
CAS No.
SMILES

OC([C@@]([C@@]1(C)C(O)=O)([C@@H]2O[C@H]1CC2)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cantharidic acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cantharidic acid28874-45-5PhosphataseApoptosisERKp38 MAPKJNKExtracellular signal regulated kinasesc-Jun N-terminal kinaseNPC-39NPC-BMHONE-1nasopharyngeal carcinomaNPCInhibitorinhibitorinhibit

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