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  4. Niemann Pick C1 Antibody (YA2290)

Niemann Pick C1 Antibody (YA2290)

Cat. No.: HY-P82545
Data Sheet SDS COA User Guide for Antibodies

Niemann Pick C1 Antibody (YA2290) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2290), targeting Niemann Pick C1, with a predicted molecular weight of 142 kDa (observed band size: 180 kDa). Niemann Pick C1 Antibody (YA2290) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL USD 70 In-stock
50 μL USD 185 In-stock
100 μL USD 300 In-stock
250 μL   Get quote  

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Description

Niemann Pick C1 Antibody (YA2290) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2290), targeting Niemann Pick C1, with a predicted molecular weight of 142 kDa (observed band size: 180 kDa). Niemann Pick C1 Antibody (YA2290) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

Background

The related gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. The protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in The related gene cause Niemann-Pick type C disease, a rare autosomal recessive neuroderelated generative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.

Gene ID

4864

Synonyms
Niemann Pick C1 protein precursor; NPC; NPC1
Molecular Weight

Predicted band size: 142 kDa; Observed band size: 180 kDa

Purity

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

Research Field

Neuroscience

Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Clonality

Recombinant, Monoclonal

Host

Rabbit

Reactivity

Human, Mouse, Rat

SwissProt ID

O15118

Dilution Ratio

WB: 1/500-1/1000;IHC: 1/50-1/100;IF: 1/50-1/200;FC: 1/50-1/100

Application

WB, IHC-P, ICC/IF, FC

Appearance

Liquid

Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Isotype

IgG

Sensitivity

Endogenous

Immunogen

A synthesized peptide derived from human Niemann Pick C1

Documentation

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Product Name:
Niemann Pick C1 Antibody (YA2290)
Cat. No.:
HY-P82545
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