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  4. Niemann Pick C1 Like 1 Antibody (YA1656)

Niemann Pick C1 Like 1 Antibody (YA1656)

Cat. No.: HY-P81911
Data Sheet User Guide for Antibodies Technical Support

Niemann Pick C1 Like 1 Antibody (YA1656) is a non-conjugated IgG antibody, targeting Niemann Pick C1 Like 1, with a predicted molecular weight of 149 kDa. Niemann Pick C1 Like 1 Antibody (YA1656) can be used for WB experiment in human background.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 5 - 6 weeks 4 - 5 weeks 4 - 5 weeks
50 μL Get quote 5 - 6 weeks 4 - 5 weeks 4 - 5 weeks
100 μL Get quote 5 - 6 weeks 4 - 5 weeks 4 - 5 weeks
250 μL   Get quote  

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Description

Niemann Pick C1 Like 1 Antibody (YA1656) is a non-conjugated IgG antibody, targeting Niemann Pick C1 Like 1, with a predicted molecular weight of 149 kDa. Niemann Pick C1 Like 1 Antibody (YA1656) can be used for WB experiment in human background.

Background

The protein encoded by The related gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. The protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets The protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, The protein may play a critical role in regulating lipid metabolism. Polymorphic variations in The related gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for The related gene.

Gene ID
SwissProt ID
Synonyms
NPC1 LIKE 1; NPC1L1
Molecular Weight

Predicted band size: 149 kDa

Purity

Affinity Chromatography

Conjugation

Non-conjugated

Modification

Unmodified

Research Field

Neuroscience

Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Clonality

Recombinant, Monoclonal

Host

Rabbit

Reactivity

Human

Dilution Ratio

WB: 1/500-1/1000

Application

WB

Appearance

Liquid

Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Isotype

IgG

Sensitivity

Endogenous

Immunogen

A synthesized peptide derived from human NPC1L1

Database
Documentation

Niemann Pick C1 Like 1 Antibody (YA1656) Related Classifications

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Product Name:
Niemann Pick C1 Like 1 Antibody (YA1656)
Cat. No.:
HY-P81911
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