Niemann Pick C1 Like 1 Antibody (YA1656)

Cat. No.: HY-P81911: FAQs
Data Sheet User Guide for Antibodies

Niemann Pick C1 Like 1 Antibody (YA1656) is a biotin-conjugated non-conjugated IgG antibody, targeting Niemann Pick C1 Like 1, with a predicted molecular weight of 149 kDa. Niemann Pick C1 Like 1 Antibody (YA1656) can be used for WB experiment in human background.

For research use only. We do not sell to patients.

Size	Price	Stock
10 μL	$70	Ask For Quote & Lead Time
50 μL	$185	Ask For Quote & Lead Time
100 μL	$300	Ask For Quote & Lead Time

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Biological Activity
Technical Parameters
Properties
Documentation

Description	Niemann Pick C1 Like 1 Antibody (YA1656) is a biotin-conjugated non-conjugated IgG antibody, targeting Niemann Pick C1 Like 1, with a predicted molecular weight of 149 kDa. Niemann Pick C1 Like 1 Antibody (YA1656) can be used for WB experiment in human background.
Background	The protein encoded by The related gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. The protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets The protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, The protein may play a critical role in regulating lipid metabolism. Polymorphic variations in The related gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for The related gene.
Gene ID	29881
Synonyms	NPC1 LIKE 1; NPC1L1
Molecular Weight	Predicted band size: 149 kDa
Purity	Affinity Chromatography
Conjugation	Non-conjugated
Modification	Unmodified
Research Field	Neuroscience
Product Categories	Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality	Recombinant, Monoclonal
Host	Rabbit
Reactivity	Human
SwissProt ID	Q9UHC9
Dilution Ratio	WB: 1/500-1/1000
Application	WB
Appearance	Liquid
Formulation	Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Sensitivity	Endogenous
Immunogen	A synthesized peptide derived from human NPC1L1
Documentation	Data Sheet (234 KB) User Guide for Antibodies (1077 KB)

Niemann Pick C1 Like 1 Antibody (YA1656) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Niemann Pick C1 Like 1 Antibody (YA1656)

Biological Activity

Technical Parameters

Properties

Documentation

Niemann Pick C1 Like 1 Antibody (YA1656) Related Classifications

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