Niemann Pick C1 Like 1 Antibody (YA1656)

Niemann Pick C1 Like 1 Antibody (YA1656) is a non-conjugated IgG antibody, targeting Niemann Pick C1 Like 1, with a predicted molecular weight of 149 kDa. Niemann Pick C1 Like 1 Antibody (YA1656) can be used for WB experiment in human background.

The protein encoded by The related gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. The protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets The protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, The protein may play a critical role in regulating lipid metabolism. Polymorphic variations in The related gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for The related gene.

29881

Predicted band size: 149 kDa

Affinity Chromatography

Non-conjugated

Unmodified

Neuroscience

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

Q9UHC9

WB: 1/500-1/1000

WB

Liquid

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human NPC1L1