KHS101

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KHS101 is a small molecule that accelerates neuronal differentiation. KHS101 can distributes to the brain and resulted in a significant increase in neuronal differentiation.

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KHS101 Chemical Structure

CAS No. : 1262770-73-9

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Other In-stock Forms of KHS101:

KHS101 hydrochloride

Other Forms of KHS101:

KHS101 hydrochloride In-stock

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Description

KHS101 is a small molecule that accelerates neuronal differentiation. KHS101 can distributes to the brain and resulted in a significant increase in neuronal differentiation^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
JIMT-1	IC₅₀	32.98 μM Compound: 7a	Antiproliferative activity against human JIMT-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferative activity against human JIMT-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 36332551]
MDA-MB-231	IC₅₀	31.13 μM Compound: 7a	Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 36332551]
SK-OV-3	IC₅₀	21.44 μM Compound: 7a	Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 36332551]
U-251	IC₅₀	49.13 μM Compound: 7a	Cytotoxicity against human U251 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Cytotoxicity against human U251 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 36332551]
U-87MG ATCC	IC₅₀	37.85 μM Compound: 7a	Antiproliferative activity against human U87 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human U87 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 36332551]

In Vitro

KHS101 induces neuronal differentiation of adherently cultured rat NPCs in a dose-dependent fashion (EC50 ∼ 1 μM)^[1].
KHS101 (5 μM) suppresses astrocyte formation in cultured NPCs^[1].
KHS101 (5 μM; 24-72 h) negatively affects cell cycle progression and proliferation of NPCs^[1].
KHS101 specifically interacts with TACC3 protein^[1].
KHS101 (0–15 μM; 24 h) regulates the nuclear localization of the transcription factor ARNT2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:	Rat NPCs
Concentration:	0.6, 1.7 and 5 μM
Incubation Time:	24 h
Result:	Showed a dose-dependent induction of Cdkn1 mRNA expression.

Cell Proliferation Assay^[1]

Cell Line:	Rat NPCs
Concentration:	5 μM
Incubation Time:	24, 48 and 72 h
Result:	The vast majority of NPCs stop proliferating within 72 h, become mitotically inactive.

In Vivo

KHS101 (6 mg/kg; s.c.; BID for 14 days) distributes to the brain and significantly increases neuronal differentiation in rats in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult Fisher 344 rats (∼10 wk old)^[1]
Dosage:	6 mg/kg
Administration:	SC, BID for 14 days
Result:	Increased neuronal differentiation. Reduced proliferation of NPCs.

Molecular Weight

339.46

Formula

C₁₈H₂₁N₅S

CAS No.

1262770-73-9

SMILES

CC(C)CNC1=NC(NCC2=CSC(C3=CC=CC=C3)=N2)=NC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wurdak H, et al. A small molecule accelerates neuronal differentiation in the adult rat. Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16542-7. [Content Brief]

KHS101 Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KHS1011262770-73-9KHS 101KHS-101OthersNPCsastrocyteTACC3ARNT2Inhibitorinhibitorinhibit

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