2. NF-κB Apoptosis
  3. Keap1-Nrf2 Apoptosis
  4. Kinsenoside

Kinsenoside is the main active ingredient of the genus plant, and has various biological activities. Kinsenoside and Nrf2 depend on the protection of nuclear cells (NPCs), which significantly reduces their ability to survive. Kinsenoside Active NPC Medium AKT-ERK1/2-Nrf2 Signal passage, Prevent physical decline, aging, harmonious physical function impairment. Kinsenoside can improve the puncture guide model for intermediate vertebral wall discharge (IDD).

For research use only. We do not sell to patients.

Kinsenoside Chemical Structure

Kinsenoside Chemical Structure

CAS No. : 151870-74-5

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5 mg USD 185 In-stock
10 mg USD 315 In-stock
25 mg USD 536 In-stock
50 mg USD 790 In-stock
100 mg USD 1100 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Kinsenoside Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Kinsenoside

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Kinsenoside is the main active ingredient of the genus plant, and has various biological activities. Kinsenoside and Nrf2 depend on the protection of nuclear cells (NPCs), which significantly reduces their ability to survive. Kinsenoside Active NPC Medium AKT-ERK1/2-Nrf2 Signal passage, Prevent physical decline, aging, harmonious physical function impairment. Kinsenoside can improve the puncture guide model for intermediate vertebral wall discharge (IDD).

Cellular Effect
Cell Line Type Value Description References
RAW264.7 IC50
41.94 μM
Compound: 1
Antiinflammatory activity against mouse RAW 264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess assay
Antiinflammatory activity against mouse RAW 264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess assay
[PMID: 33223464]
In Vitro

Kinsenoside (5-50 μg/mL; 24 h) suppresses NPC apoptosis and senescence under THBP (100 μM)-induced oxidative stresss in nucleus pulposus cells (NPCs), by dose-dependently inhibiting the protein levels of C-caspase3 and p16[1].
Kinsenoside activates the AKT-ERK1/2-Nrf2 signaling pathway through the phosphorylation of AKT and ERK1/2 in nucleus pulposus cells (NPCs)[1].
Kinsenoside (10-50 μM; 30 min) inhibits LPS (1 μg/mL)-induced the production of inflammatory mediators such as nitric oxide, TNF-α, IL-1β, monocyte chemoattractant protein 1, and macrophage migration inhibitory factor[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Kinsenoside Related Antibodies
In Vivo

Kinsenoside (10 mg/kg; ip; every 3 days for 4 weeks) promotes the expression of Nrf2 and ameliorates intervertebral disc degeneration (IDD) induced by Pentobarbital (50 mg/kg) in vivo in rat model[1].
Kinsenoside (100 mg/kg, 300 mg/kg; ip; 1 h before LPS induction) inhibits LPS (40 mg/kg; ip)-induced inflammatory model in mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

264.23

Formula

C10H16O8
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C1OC[C@H](O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (378.46 mM)

DMSO : 50 mg/mL (189.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7846 mL 18.9229 mL 37.8458 mL
5 mM 0.7569 mL 3.7846 mL 7.5692 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (9.46 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (9.46 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.91%

SDS (393 KB)

COA (250 KB) HNMR (144 KB) RP-HPLC (74 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 3.7846 mL 18.9229 mL 37.8458 mL 94.6145 mL
5 mM 0.7569 mL 3.7846 mL 7.5692 mL 18.9229 mL
10 mM 0.3785 mL 1.8923 mL 3.7846 mL 9.4615 mL
15 mM 0.2523 mL 1.2615 mL 2.5231 mL 6.3076 mL
20 mM 0.1892 mL 0.9461 mL 1.8923 mL 4.7307 mL
25 mM 0.1514 mL 0.7569 mL 1.5138 mL 3.7846 mL
30 mM 0.1262 mL 0.6308 mL 1.2615 mL 3.1538 mL
40 mM 0.0946 mL 0.4731 mL 0.9461 mL 2.3654 mL
50 mM 0.0757 mL 0.3785 mL 0.7569 mL 1.8923 mL
60 mM 0.0631 mL 0.3154 mL 0.6308 mL 1.5769 mL
80 mM 0.0473 mL 0.2365 mL 0.4731 mL 1.1827 mL
100 mM 0.0378 mL 0.1892 mL 0.3785 mL 0.9461 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Kinsenoside Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kinsenoside151870-74-5Keap1-Nrf2ApoptosisintervertebraldiscdegenerationNrf2nucleuspulposuscellsInhibitorinhibitorinhibit

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