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PBP2

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-139745
    FPI-1523 sodium

    		Beta-lactamase Bacterial Infection
    FPI-1523 sodium, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 sodium also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 sodium exhibits considerable antimicrobial activity .
    FPI-1523 sodium
  • HY-120859
    Zidebactam
    Maximum Cited Publications
    6 Publications Verification

    WCK-5107

    		 Beta-lactamase Penicillin-binding protein (PBP) Bacterial Infection
    Zidebactam (WCK-5107) is a potent β-lactamase inhibitor . Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC50 of 0.26 μg/mL [2].
    Zidebactam
  • HY-109008
    Nacubactam
    1 Publications Verification

    OP0595 free acid

    		 Beta-lactamase Bacterial Infection
    Nacubactam (OP0595 free acid) is a potent non-β-lactam-β-lactamase inhibitor with activity against class A and class C β-lactamases. Nacubactam (OP0595 free acid) acts as a penicillin binding protein (PBP) 2-active antibacterial, and gives β-lactamase-independent potentiation of β-lactams targeting other PBPs [2].
    Nacubactam
  • HY-120366
    WCK-5153

    		Penicillin-binding protein (PBP) Beta-lactamase Bacterial Infection
    WCK-5153 is a Penicillin-Binding Protein 2 (PBP2) inhibitor with an IC50 of 0.14 μg/ml (for P. aeruginosa PBP2) and acts as a β-lactam enhancer against Pseudomonas aeruginosa. WCK-5153 can be used in studies of multidrug-resistant (MDR) pathogens .
    WCK-5153
  • HY-139745A
    FPI-1523

    		Beta-lactamase Bacterial Infection
    FPI-1523, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 exhibits considerable antimicrobial activity .
    FPI-1523
  • HY-120859A
    Zidebactam sodium salt

    WCK-5107 sodium salt

    		 Beta-lactamase Penicillin-binding protein (PBP) Bacterial Infection
    Zidebactam sodium salt (WCK-5107 sodium salt) is a potent β-lactamase inhibitor . Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC50 of 0.26 μg/mL [2].
    Zidebactam sodium salt
  • HY-139744
    FPI-1465

    		Beta-lactamase Penicillin-binding protein (PBP) Bacterial Infection
    FPI-1465 acts a dual inhibitor of serine-β-Lactamases and Penicillin-binding proteins (PBPs).FPI-1465 inhibits PBP2 (IC50=1.0 µg/mL). FPI-1465 exhibits activity against β-lactamase CTX-M-15 and OXA-48 with Kds of 0.011 and 5.3 µM, respectively .
    FPI-1465
  • HY-W013376
    Norcyclizine

    1-(Diphenylmethyl)piperazine; 1-Benzhydrylpiperazine

    		 Antibiotic Bacterial Penicillin-binding protein (PBP) Infection Cancer
    Norcyclizine is a piperazine compound that can be used for the synthesis of antimicrobial agents. 1-Benzhydrylpiperazine derivatives have been found to enhance the antibacterial activity of β-lactam antibiotics (Oxacillin, HY-B0925A) against Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA). This enhancement is likely achieved by inhibiting the allosteric site of PBP2a. Additionally, 1-Benzhydrylpiperazine can also serve as a pharmacological scaffold for the synthesis of anticancer agents [2].
    Norcyclizine

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