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Results for "

PET tracer

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (1) Amyloid-β (1) Bcr-Abl (1) Biochemical Assay Reagents (4) CXCR (1) Cytochrome P450 (1) FAAH (1) FAP (5) Fluorescent Dye (1) iGluR (2) mAChR (2) mGluR (2) Oxidative Phosphorylation (1) Phosphodiesterase (PDE) (2) Prolyl Endopeptidase (PREP) (1) PSMA (2) Radionuclide-Drug Conjugates (RDCs) (2) Tau Protein (1)
By Research Areas:	Cancer (12) Neurological Disease (11)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139048

Fluoroethylnormemantine	iGluR	Neurological Disease
Fluoroethylnormemantine, a derivative of Memantine, is an antagonist of the N-methyl-D-aspartate (NMDA) receptor. [ ¹⁸F]-Fluoroethylnormemantine can be used as a positron emission tomography (PET) tracer. Fluoroethylnormemantine exhibits anti-amnesic, neuroprotective, antidepressant-like and fear-attenuating effects .

HY-139048A

Fluoroethylnormemantine hydrochloride	iGluR	Neurological Disease
Fluoroethylnormemantine hydrochloride, a derivative of Memantine, is an antagonist of the N-methyl-D-aspartate (NMDA) receptor. [ ¹⁸F]-Fluoroethylnormemantine hydrochloride can be used as a positron emission tomography (PET) tracer. Fluoroethylnormemantine hydrochloride exhibits anti-amnesic, neuroprotective, antidepressant-like and fear-attenuating effects .

HY-101184

T807 2 Publications Verification AV-1451	Tau Protein	Neurological Disease
T807 a novel tau positron emission tomography (PET) tracer.

HY-W007746

1-Cyclohexeneboronic acid pinacol ester	Biochemical Assay Reagents	Others
1-Cyclohexeneboronic acid pinacol ester (Compound 4) is an organic borate that can be used in the synthesis of PET tracers .

HY-159001

ZCDD083	Biochemical Assay Reagents	Others
ZCDD083 can be used as a positron emission tomography (PET) tracer for atherosclerotic plaques imagination, when labeled with ¹⁸F isotope .

HY-162574

CYP11B2-IN-2	Cytochrome P450	Cancer
CYP11B2-IN-2 (Compound 10k) is an inhibitor for enzyme aldosterone synthase CYP11B2 with an IC₅₀ of 0.3 nM. CYP11B2-IN-2 CYP11B-IN-2 is labeled with 18F and can be used as a positron emission tomography (PET) tracer for the diagnosis of primary aldosteronism .

HY-169071S

ATX-1905	Phosphodiesterase (PDE)	Others
ATX-1905 is a positron emission tomography (PET) tracer that demonstrates good autotaxin (ATX) binding specificity and achieves semiquantification of lung ATX expression levels, which are elevated in fibrotic lungs. ATX-1905 exhibits elevated uptake in Bleomycin (HY-108345)-induced pulmonary fibrosis (BPF) lungs. ATX-1905 is promising for research of idiopathic pulmonary fibrosis (IPF) .

HY-120717

VU6001966	mGluR	Others
VU6001966 (compound 15m) is a potent and cross the blood-brain barrier mGlu2 (metabotropic glutamate receptor 2) negative allosteric modulator with IC₅₀s of 78 nM and >30 µM for mGlu2 and mGlu3, respectively. VU6001966 can serve as an mGlu2 PET tracer .

HY-156982

Parpi	Others	Cancer
Parpi is a PET radioactive tracer with low lipotropy. Parpi can be used as a tumor imaging agent .

HY-163075

SYB4	Others	Others
SYB4 (compound 5) is a PET tracer which suitable for imaging the Sigma-2 Receptor in the brain of nonhuman primates .

HY-101186

MK-6240 1 Publications Verification	Others	Neurological Disease
MK-6240 is a tau positron emission tomography (PET) tracer for neurofibrillary tangles (NFTs), exhibiting high specificity and selectivity for binding to NFTs .

HY-147173

FAPI-74	FAP	Cancer
FAPI-74 is a PET (positron emission tomography) tracer targeting the fibroblast activation protein (FAP). FAPI-74 can be used for FAP-positive tumor research .

HY-153550

PSMA-1007	PSMA	Others
PSMA-1007 is a prostate-specific membrane antigen (PSMA) ligand. ¹⁸F-labeled PSMA-1007 can be used as a PET tracer for prostate cancer imaging .

HY-111514

4-(6-Bromo-2-benzothiazolyl)benzenamine	Oxidative Phosphorylation Amyloid-β	Neurological Disease
4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET (positron emission tomography) tracer that can be used in the diagnosis of neurological diseases, such as Alzheimer's and Down's syndrome.

HY-110141

ABP688	mGluR	Others
ABP688 is a high affinity human mGluR5 antagonist with anK_i of 1.7 nM. Radioisotope-labeled ABP688 can be used as a PET tracer for clinical imaging of the mGlu5 receptor .

HY-158326

FAP-IN-4	FAP	Cancer
FAP-IN-4 (Comp 10) is a fibroblast activation protein (FAP) inhibitor and a ¹⁸F-labeled PET tracer targeting FAP. FAP-IN-4 can be used for cancer research .

HY-158317

SFB-AMD3465	CXCR Biochemical Assay Reagents	Others
SFB-AMD3465 is an AMD3465 (HY-15971A) derivative. SFB-AMD3465 is utilized as positron emission tomography (PET) tracer for CXCR4, when labeled with radioactive Fluorine .

HY-126226

MK-6240 Precursor	Others	Cancer
MK-6240 Precursor (6e) is the synthetic precursor of (18)F]-MK-6240. (18)F]-MK-6240 is a tau positron emission tomography (PET) tracer for neurofibrillary tangles (NFTs), exhibiting high specificity and selectivity for binding to NFTs .

HY-42110

Deschloroclozapine Maximum Cited Publications 43 Publications Verification	mAChR	Neurological Disease
Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with K_i of 6.3 and 4.2 nM, respectively. [ ¹¹C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging .

HY-42110A

Deschloroclozapine dihydrochloride Maximum Cited Publications 43 Publications Verification	mAChR	Neurological Disease
Deschloroclozapine dihydrochloride, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with K_i of 6.3 and 4.2 nM, respectively. [ ¹¹C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging .

HY-161965

MK-3168 (12C)	FAAH	Neurological Disease
MK-3168 (12C) is a FAAH inhibitor with IC₅₀ values of 1.0, 5.5, 1.7 nM for human, rhesus, rat, respectively. MK-3168 shows good brain uptake and FAAH-specific signal. ¹¹C MK-3168 can be used as FAAH PET tracer .

HY-125399

PSMA-11 HBED-CC-PSMA	PSMA Radionuclide-Drug Conjugates (RDCs)	Cancer
PSMA-11 is a small molecule ligand that targets prostate-specific membrane antigen (PSMA) and has the ability to inhibit PSMA activity. PSMA-11 can be used to synthesize ⁶⁸Ga-PSMA-11, a positron emission tomography (PET) tracer that can be used to image advanced prostate cancer .

HY-141464

Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH Fmoc-Asn(Ac3AcNH-beta-Glc)-OH	Amino Acid Derivatives	Cancer
Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH (Fmoc-Asn(Ac3AcNH-beta-Glc)-OH) can be used in the synthesis of silicon-fluoride acceptor (SiFA) derivatized octreotate derivatives. SiFA-octreotate analogues, as tumor imaging agents, are useful tool for the research of positron emission tomography (PET) .

HY-W422400

Fluoroglutamine (2S,4R)	Biochemical Assay Reagents	Others Cancer
Fluoroglutamine (2S,4R) is a fluorinated derivative of glutamine. As a substrate for various aminotransferases, Fluoroglutamine (2S,4R) can be used as a tracer for positron emission tomography (PET) imaging. Fluoroglutamine (2S,4R) is applied in the research fields of tumor metabolism and imaging .

HY-163281

FSY-OSO2F	Fluorescent Dye	Cancer
FSY-OSO2F shows an uptake in MCF-7 cells through the regulation of L-Tyr, ASC, and ASC2 transporters. FSY-OSO2F can be used as a PET tracer, when labeled with ¹⁸F, and exhibits good uptake and good contrast in MCF-7 and 22Rv1 subcutaneous tumors .

HY-128642

FAPI-2	FAP	Cancer
FAPI-2 is a type of small molecule fibroblast activation protein inhibitor (FAPI) that targets the fibroblast activation protein (FAP) and has an inhibitory effect. This specific targeting ability makes FAPI-2 an effective tumor imaging agent, which can be used in cancer research. FAPI-2 can be used to synthesize 68Ga-FAPI-2 (a PET tracer) .

HY-119190

PF-06445974	Phosphodiesterase (PDE)	Neurological Disease
PF-06445974, a promising positron emission tomography (PET) lead, has exquisite potency at PDE4B with an IC₅₀ <1 nM. The IC₅₀ values are 36, 4.7 and 17 nM for PDE4D, PDE4A and PDE4C, respectively. PF-06445974 has good selectivity over PDE4D, excellent brain permeability, and a high level of specific binding in the "cold tracer" study .

HY-D2363

DOTA.SA.FAPi TFA	Radionuclide-Drug Conjugates (RDCs) FAP Prolyl Endopeptidase (PREP)	Cancer
DOTA.SA.FAPi TFA is a bifunctional DATA5m and DOTA chelator, which is composed of the squaric acid and UAMC1110. DOTA.SA.FAPi TFA inhibits fibroblast activation protein (FAP) with an IC₅₀ of 0.9 nM. DOTA.SA.FAPi TFA targets protease PREP with an IC₅₀ of 5.4 μM. DOTA.SA.FAPi TFA can be used a PET tracer, when labeled with ⁶⁸Ga, and used for research about cancer .

HY-128642A

FAPI-2 TFA	FAP	Cancer
FAPI-2 TFA is a type of small molecule fibroblast activation protein inhibitor (FAPI) that targets the fibroblast activation protein (FAP) and has an inhibitory effect. This specific targeting ability makes FAPI-2 TFA an effective tumor imaging agent, which can be used in cancer research. FAPI-2 TFA can be used to synthesize 68Ga-FAPI-2 (a PET tracer) .

HY-156102

c-ABL-IN-5	Bcr-Abl	Neurological Disease
c-ABL-IN-5 is a selective c-Abl inhibitor with neuroprotective effects. c-ABL-IN-5 has blood-brain barrier penetrability, metabolic stability and good pharmacokinetic properties. When c-ABL-IN-5 is labeled with [18F] (compound [18F]3), it can be used as a tracer to evaluate disease-modifying efficacy by complementary positron emission tomography (PET). c-ABL-IN-5 can be used in the study of neurodegenerative diseases such as Parkinson's disease (PD) .

HY-123446

JNJ-42259152	Others	Neurological Disease
JNJ-42259152 is a phosphodiesterase 10A (PDE10A) positron emission tomography (PET) tracer that is specific for PDE10A activity. JNJ-42259152 can be dynamically scanned in healthy volunteers to assess its kinetic properties in the brain. The half-life of JNJ-42259152 in the blood is an average of 90 minutes. JNJ-42259152 has demonstrated reliable binding potential (BPND) in different target areas (such as the lentiform nucleus, caudate nucleus, ventral striatum, etc.), providing an important tool for studying neuropsychiatric diseases .

1-Cyclohexeneboronic acid pinacol ester	Biochemical Assay Reagents
1-Cyclohexeneboronic acid pinacol ester (Compound 4) is an organic borate that can be used in the synthesis of PET tracers .

Cat. No.	Product Name	Target	Research Area

HY-153550

PSMA-1007	PSMA	Others
PSMA-1007 is a prostate-specific membrane antigen (PSMA) ligand. ¹⁸F-labeled PSMA-1007 can be used as a PET tracer for prostate cancer imaging .

HY-D2363

DOTA.SA.FAPi TFA	Radionuclide-Drug Conjugates (RDCs) FAP Prolyl Endopeptidase (PREP)	Cancer
DOTA.SA.FAPi TFA is a bifunctional DATA5m and DOTA chelator, which is composed of the squaric acid and UAMC1110. DOTA.SA.FAPi TFA inhibits fibroblast activation protein (FAP) with an IC₅₀ of 0.9 nM. DOTA.SA.FAPi TFA targets protease PREP with an IC₅₀ of 5.4 μM. DOTA.SA.FAPi TFA can be used a PET tracer, when labeled with ⁶⁸Ga, and used for research about cancer .

Cat. No.	Product Name	Chemical Structure

HY-169071S

ATX-1905
ATX-1905 is a positron emission tomography (PET) tracer that demonstrates good autotaxin (ATX) binding specificity and achieves semiquantification of lung ATX expression levels, which are elevated in fibrotic lungs. ATX-1905 exhibits elevated uptake in Bleomycin (HY-108345)-induced pulmonary fibrosis (BPF) lungs. ATX-1905 is promising for research of idiopathic pulmonary fibrosis (IPF) .

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