2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Fluoroethylnormemantine hydrochloride

Fluoroethylnormemantine hydrochloride 

Cat. No.: HY-139048A Purity: ≥98.0%
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Fluoroethylnormemantine hydrochloride, a derivative of Memantine, is an antagonist of the N-methyl-D-aspartate (NMDA) receptor. [18F]-Fluoroethylnormemantine hydrochloride can be used as a positron emission tomography (PET) tracer. Fluoroethylnormemantine hydrochloride exhibits anti-amnesic, neuroprotective, antidepressant-like and fear-attenuating effects.

For research use only. We do not sell to patients.

Fluoroethylnormemantine hydrochloride Chemical Structure

Fluoroethylnormemantine hydrochloride Chemical Structure

CAS No. : 1639210-25-5

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Based on 1 publication(s) in Google Scholar

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Fluoroethylnormemantine hydrochloride Related Antibodies

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Description

Fluoroethylnormemantine hydrochloride, a derivative of Memantine, is an antagonist of the N-methyl-D-aspartate (NMDA) receptor. [18F]-Fluoroethylnormemantine hydrochloride can be used as a positron emission tomography (PET) tracer. Fluoroethylnormemantine hydrochloride exhibits anti-amnesic, neuroprotective, antidepressant-like and fear-attenuating effects[1][2][3].

IC50 & Target

NMDA receptor[1]
In Vivo

Fluoroethylnormemantine (0.1-10 mg/kg; a single i.p.) shows anti-amnesic effects on Aβ 25-35-induced learning impairments in mice[1].
Fluoroethylnormemantine (0.1-10 mg/kg; i.p. once daily for 7 days) attenuates Aβ 25-35-induced behavioral deficits, neuroinflammation, oxidative stress, apoptosis, and cell loss in mice[1].
Fluoroethylnormemantine (1-20 mg/kg; a single injection) decreases behavioral despair in the forced swim test (FST) and reduces fear behavior in the cued fear conditioning (FC) and extinction training in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss CD-1 mice (7-9 weeks) were injected with Aβ25-35[1]
Dosage: 0.1, 0.3, 1, 3, 10 mg/kg
Administration: I.p. 30 minutes before the behavioral tests
Result: Attenuated Aβ 25-35-induced spontaneous alternation deficit, passive avoidance deficit, and novel object exploration deficit.
Clinical Trial
Molecular Weight

233.75

Formula

C12H21ClFN
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[H]Cl.FCC[C@](C[C@H](C1)C2)(C[C@@H]1C3)C[C@]23N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (427.81 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2781 mL 21.3904 mL 42.7808 mL
5 mM 0.8556 mL 4.2781 mL 8.5561 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.2781 mL 21.3904 mL 42.7807 mL 106.9519 mL
5 mM 0.8556 mL 4.2781 mL 8.5561 mL 21.3904 mL
10 mM 0.4278 mL 2.1390 mL 4.2781 mL 10.6952 mL
15 mM 0.2852 mL 1.4260 mL 2.8520 mL 7.1301 mL
20 mM 0.2139 mL 1.0695 mL 2.1390 mL 5.3476 mL
25 mM 0.1711 mL 0.8556 mL 1.7112 mL 4.2781 mL
30 mM 0.1426 mL 0.7130 mL 1.4260 mL 3.5651 mL
40 mM 0.1070 mL 0.5348 mL 1.0695 mL 2.6738 mL
50 mM 0.0856 mL 0.4278 mL 0.8556 mL 2.1390 mL
60 mM 0.0713 mL 0.3565 mL 0.7130 mL 1.7825 mL
80 mM 0.0535 mL 0.2674 mL 0.5348 mL 1.3369 mL
100 mM 0.0428 mL 0.2139 mL 0.4278 mL 1.0695 mL
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Fluoroethylnormemantine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fluoroethylnormemantine1639210-25-5iGluRIonotropic glutamate receptorsMemantineNMDApositronemissiontomographyPETtracerantidepressantfearanti-amnesicneuroprotectiveAlzheimerInhibitorinhibitorinhibit

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