Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH (Synonyms: Fmoc-Asn(Ac3AcNH-beta-Glc)-OH)

Name: Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH
Brand: MedChemExpress
SKU: HY-141464
Rating: 4.5 (1 reviews)

Cat. No.: HY-141464 Purity: 95.03%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH (Fmoc-Asn(Ac3AcNH-beta-Glc)-OH) can be used in the synthesis of silicon-fluoride acceptor (SiFA) derivatized octreotate derivatives. SiFA-octreotate analogues, as tumor imaging agents, are useful tool for the research of positron emission tomography (PET).

For research use only. We do not sell to patients.

Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH Chemical Structure

CAS No. : 131287-39-3

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 95	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 980	In-stock	Estimated Time of Arrival: December 31
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500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

Molecular Weight

683.66

Formula

C₃₃H₃₇N₃O₁₃

CAS No.

131287-39-3

Appearance

Solid

Color

White to off-white

SMILES

CC(N[C@H]([C@H]([C@@H]([C@H](O1)COC(C)=O)OC(C)=O)OC(C)=O)[C@@H]1NC(C[C@@H](C(O)=O)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (182.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4627 mL	7.3136 mL	14.6272 mL
5 mM	0.2925 mL	1.4627 mL	2.9254 mL
10 mM	0.1463 mL	0.7314 mL	1.4627 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.04 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (3.04 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 95.03%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (254 KB) HNMR (303 KB) LCMS (262 KB)

Handling Instructions (2659 KB)

References

[1]. Wängler C, et al. One-step ^¹⁸F-labeling of carbohydrate-conjugated octreotate-derivatives containing a silicon-fluoride-acceptor (SiFA): in vitro and in vivo evaluation as tumor imaging agents for positron emission tomography (PET). Bioconjug Chem. 2010;21(12):2289-2296. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4627 mL	7.3136 mL	14.6272 mL	36.5679 mL
	5 mM	0.2925 mL	1.4627 mL	2.9254 mL	7.3136 mL
	10 mM	0.1463 mL	0.7314 mL	1.4627 mL	3.6568 mL
	15 mM	0.0975 mL	0.4876 mL	0.9751 mL	2.4379 mL
	20 mM	0.0731 mL	0.3657 mL	0.7314 mL	1.8284 mL
	25 mM	0.0585 mL	0.2925 mL	0.5851 mL	1.4627 mL
	30 mM	0.0488 mL	0.2438 mL	0.4876 mL	1.2189 mL
	40 mM	0.0366 mL	0.1828 mL	0.3657 mL	0.9142 mL
	50 mM	0.0293 mL	0.1463 mL	0.2925 mL	0.7314 mL
	60 mM	0.0244 mL	0.1219 mL	0.2438 mL	0.6095 mL
	80 mM	0.0183 mL	0.0914 mL	0.1828 mL	0.4571 mL
	100 mM	0.0146 mL	0.0731 mL	0.1463 mL	0.3657 mL

Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

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Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH (Synonyms: Fmoc-Asn(Ac3AcNH-beta-Glc)-OH)

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Complete Stock Solution Preparation Table

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