2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. FAP Prolyl Endopeptidase (PREP)
  4. DOTA.SA.FAPi TFA

DOTA.SA.FAPi TFA is a bifunctional DATA5m and DOTA chelator, which is composed of the squaric acid and UAMC1110. DOTA.SA.FAPi TFA inhibits fibroblast activation protein (FAP) with an IC50 of 0.9 nM. DOTA.SA.FAPi TFA targets protease PREP with an IC50 of 5.4 μM. DOTA.SA.FAPi TFA can be used a PET tracer, when labeled with 68Ga, and used for research about cancer.

For research use only. We do not sell to patients.

DOTA.SA.FAPi TFA Chemical Structure

DOTA.SA.FAPi TFA Chemical Structure

Size Price Stock Quantity
100 μg USD 210 In-stock
500 μg USD 530 In-stock
1 mg USD 850 In-stock
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Based on 1 publication(s) in Google Scholar

DOTA.SA.FAPi TFA Related Antibodies

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Description

DOTA.SA.FAPi TFA is a bifunctional DATA5m and DOTA chelator, which is composed of the squaric acid and UAMC1110. DOTA.SA.FAPi TFA inhibits fibroblast activation protein (FAP) with an IC50 of 0.9 nM. DOTA.SA.FAPi TFA targets protease PREP with an IC50 of 5.4 μM. DOTA.SA.FAPi TFA can be used a PET tracer, when labeled with 68Ga, and used for research about cancer[1].

IC50 & Target

IC50: 0.9 nM (FAP); 5.4 μM (PREP)
Molecular Weight

1069.98

Formula

C45H56F5N11O14
Appearance

Solid

SMILES

O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(NCCNC(C2=O)=C(NCCCCOC3=CC(C(C(NCC(N4[C@H](C#N)CC(F)(F)C4)=O)=O)=CC=N5)=C5C=C3)C2=O)=O)CC1.OC(C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
References
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DOTA.SA.FAPi TFA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DOTA.SA.FAPiFAPProlyl Endopeptidase (PREP)Fibroblast activation protein prolyl oligopeptidasePOPHT-29colorectal cancerbreast cancerInhibitorinhibitorinhibit

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