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Isoforms Recommended:	PLD

Results for "

PLD2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (2) Dopamine Receptor (1) Fungal (1) Interleukin Related (1) Liposome (1) Phospholipase (12) Small Interfering RNA (siRNA) (1) TNF Receptor (1)
By Research Areas:	Cancer (11) Infection (2) Inflammation/Immunology (6) Metabolic Disease (2) Neurological Disease (2)
Oligonucleotides:	Pre-designed siRNA Sets (1) Phospholipids (1) siRNAs (1)

15

Inhibitors & Agonists

1

Biochemical Assay Reagents

2

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

VU0364739	Phospholipase	Cancer
VU0364739 is a selective *PLD2* inhibitor (IC₅₀: 22 nM). VU0364739 decreases cancer cell proliferation .

ML-298	Phospholipase	Cancer
ML298 is a potent and selective inhibitor of Phospholipase D2 (PLD2) with an IC₅₀ of 355 nM. ML298 decreases invasive migration in U87-MG glioblastoma cells .

FIPI 4 Publications Verification 5-Fluoro-2-indolyl deschlorohalopemide	Phospholipase Autophagy	Inflammation/Immunology Cancer
FIPI (5-Fluoro-2-indolyl des-chlorohalopemide), a derivative of Halopemide (HY-119093), is a phospholipase D (PLD) inhibitor with IC₅₀s of approximately 25 nM and 20 nM for PLD1 and PLD2, respectively. FIPI inhibits PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis. FIPI has the potential for autoimmunity and cancer metastasis research ^[2] .

Halopemide	Phospholipase Dopamine Receptor	Neurological Disease Cancer
Halopemide is a potent phospholipase D (PLD) inhibitor, with IC₅₀s of 220 and 310 nM for human PLD1 and PLD2, respectively. Halopemid is a dopamine receptors antagonist, and acts a psychotropic agent ^[2].

A3373	Phospholipase	Inflammation/Immunology
A3373, a novel chemical inhibitor of Phospholipase D1 (PLD1) and PLD2, with IC₅₀ of 325 nM and 15.15?μM, respectively, inhibits LPS-induced immune response and plays important roles in autoimmune arthritis, bone demineralization and osteoclastogenesis ^[2].

PLD2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PLD2 Human Pre-designed siRNA Set A contains three designed siRNAs for PLD2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PLD2 Human Pre-designed siRNA Set A PLD2 Human Pre-designed siRNA Set A

VU0155069 hydrochloride CAY10593 hydrochloride	Phospholipase	Cancer
VU0155069 hydrochloride (CAY10593 hydrochloride) is a potent selective phospholipase D (PLD) inhibitor. The IC₅₀ values for *PLD1* and *PLD2* are 46 and 933 nM, respectively. VU0155069 hydrochloride inhibits migration of human and mouse breast cancer cell lines ^[2].

VU 0364739 hydrochloride	Phospholipase	Cancer
VU 0364739 hydrochloride is a highly selective phospholipase D2 (PLD2) inhibitor with IC₅₀s of 20 and 1500 nM for PLD2 and PLD1, respectively. VU 0364739 hydrochloride induces apoptosis and it can be used for cancer research .

FIPI hydrochloride 5-Fluoro-2-indolyl deschlorohalopemide hydrochloride	Phospholipase Autophagy	Inflammation/Immunology Cancer
FIPI (5-Fluoro-2-indolyl des-chlorohalopemide) hydrochloride, a derivative of Halopemide (HY-119093), is a phospholipase D (PLD) inhibitor with IC₅₀s of approximately 25 nM and 20 nM for PLD1 and PLD2, respectively. FIPI hydrochloride inhibits PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis. FIPI hydrochloride has the potential for autoimmunity and cancer metastasis research ^[2] .

A4333	Phospholipase	Cancer
A4333 is biotinylated compound of A3373 (HY-155342) that inhibits Phospholipase D1 (PLD1), but not PLD2. A4333 plays an important role in antitumor activity .

Dioleoylphosphatidylglycerol DOPG	Liposome	Inflammation/Immunology
Dioleoylphosphatidylglycerol (DOPG) is a naturally occurring phospholipid that can be produced by the combined action of aquaporin 3 (AQP3) and phospholipase D2 (PLD2). Dioleoylphosphatidylglycerol inhibits macrophage inflammatory mediator production in response to heat shock protein B4 (HSPB4) activation of toll-like receptor 2 (TLR2) .

BML-280 VU0285655-1	Phospholipase TNF Receptor Interleukin Related	Metabolic Disease Inflammation/Immunology Cancer
BML-280 (VU0285655-1) is a potent and selective phospholipase D2 (PLD2) inhibitor. BML-280 has the ability to prevent caspase-3 cleavage and reduction in cell viability induced by high glucose. BML-280 can be used for rheumatoid arthritis research ^[2].

CAY10594	Phospholipase	Cancer
CAY10594 is a potent phospholipase D2 (PLD2) inhibitor both in vitro (IC₅₀=140 nM) and in cells (IC₅₀=110 nM) . CAY10594 strongly inhibits the invasive migration of breast cancer cells in vitro and ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis ^[2].

VU0359595 CID-53361951; ML-270	Phospholipase Fungal	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
VU0359595 (CID-53361951; ML-270) is a potent and selective pharmacological phospholipase D1 (PLD1) inhibitor with an IC₅₀ of 3.7 nM. VU0359595 is >1700-fold selective for PLD1 over PLD2 (IC₅₀ of 6.4 μM). VU0359595 can be used for the research of cancer, diabetes, neurodegenerative and inflammatory diseases ^[2] .

ML395	Others	Infection
ML395 is a potent and selective allosteric inhibitor of phospholipase D2 with antiviral activity. The cellular PLD1 IC50 value of ML395 exceeds 30,000 nM, while its cellular PLD2 IC50 value is 360 nM. ML395 shows excellent pharmacokinetic characteristics in vitro and physiochemical properties superior to other reported phospholipase inhibitors. ML395 shows interesting antiviral activity in cell-based assays against multiple influenza virus strains (H1, H3, H5, and H7) .

Cat. No.	Product Name	Type

Dioleoylphosphatidylglycerol DOPG	Drug Delivery
Dioleoylphosphatidylglycerol (DOPG) is a naturally occurring phospholipid that can be produced by the combined action of aquaporin 3 (AQP3) and phospholipase D2 (PLD2). Dioleoylphosphatidylglycerol inhibits macrophage inflammatory mediator production in response to heat shock protein B4 (HSPB4) activation of toll-like receptor 2 (TLR2) .

Cat. No.	Product Name		Classification

PLD2 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
PLD2 Human Pre-designed siRNA Set A contains three designed siRNAs for PLD2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dioleoylphosphatidylglycerol DOPG		Phospholipids
Dioleoylphosphatidylglycerol (DOPG) is a naturally occurring phospholipid that can be produced by the combined action of aquaporin 3 (AQP3) and phospholipase D2 (PLD2). Dioleoylphosphatidylglycerol inhibits macrophage inflammatory mediator production in response to heat shock protein B4 (HSPB4) activation of toll-like receptor 2 (TLR2) .

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