2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. ML-298

ML298 is a potent and selective inhibitor of Phospholipase D2 (PLD2) with an IC50 of 355 nM. ML298 decreases invasive migration in U87-MG glioblastoma cells.

For research use only. We do not sell to patients.

ML-298 Chemical Structure

ML-298 Chemical Structure

CAS No. : 1426916-02-0

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1 mg USD 40 In-stock
5 mg USD 100 In-stock
10 mg USD 160 In-stock
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Based on 1 publication(s) in Google Scholar

ML-298 Related Antibodies

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Phospholipase A PLD Phospholipase C

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Description

ML298 is a potent and selective inhibitor of Phospholipase D2 (PLD2) with an IC50 of 355 nM. ML298 decreases invasive migration in U87-MG glioblastoma cells[1].

Molecular Weight

432.44

Formula

C22H23F3N4O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC1=CC=C(C=C1F)C(NCCN2CCC3(CC2)C(NCN3C4=CC(F)=CC=C4)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (289.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3125 mL 11.5623 mL 23.1246 mL
5 mM 0.4625 mL 2.3125 mL 4.6249 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (248 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3125 mL 11.5623 mL 23.1246 mL 57.8115 mL
5 mM 0.4625 mL 2.3125 mL 4.6249 mL 11.5623 mL
10 mM 0.2312 mL 1.1562 mL 2.3125 mL 5.7811 mL
15 mM 0.1542 mL 0.7708 mL 1.5416 mL 3.8541 mL
20 mM 0.1156 mL 0.5781 mL 1.1562 mL 2.8906 mL
25 mM 0.0925 mL 0.4625 mL 0.9250 mL 2.3125 mL
30 mM 0.0771 mL 0.3854 mL 0.7708 mL 1.9270 mL
40 mM 0.0578 mL 0.2891 mL 0.5781 mL 1.4453 mL
50 mM 0.0462 mL 0.2312 mL 0.4625 mL 1.1562 mL
60 mM 0.0385 mL 0.1927 mL 0.3854 mL 0.9635 mL
80 mM 0.0289 mL 0.1445 mL 0.2891 mL 0.7226 mL
100 mM 0.0231 mL 0.1156 mL 0.2312 mL 0.5781 mL
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ML-298 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ML-2981426916-02-0ML298ML 298PhospholipaseInhibitorinhibitorinhibit

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