SF-1

By Targets:	ADC Linker (2) MicroRNA (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (8) Endocrinology (2) Inflammation/Immunology (2) Metabolic Disease (2)
Oligonucleotides:	Pre-designed siRNA Sets (2) siRNAs (2)

Targets Recommended: SF3B1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107404

SID 7969543	Others	Endocrinology
SID 7969543 is a selective *SF-1* (steroidogenic factor 1, NR5A1) inhibitor with an IC₅₀ of 760 nM. SID 7969543 inhibits SF-1-triggered luciferase expression with IC₅₀ of 30 nM. SF-1 is a transcription factor belonging to the nuclear receptor superfamily ^[1] .

HY-131445B

RR-RJW100	Others	Metabolic Disease
RR-RJW100, the enantiomer of RJW100, is an nuclear receptor liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1) agonist. RJW100 can be synthesized as two enantiomers, RR-RJW100 and SS-RJW100, with RR-RJW100 shown to be the more potent LRH-1 agonist. RR-RJW100 is involved in the regulation of metabolic homeostasis and is used in studies of diabetes, liver disease and inflammatory bowel disease ^[1] .

HY-115613

ML-180 1 Publications Verification SR1848	Others	Cancer
ML-180 (SR1848) is a potent orphan nuclear receptor *liver receptor homolog 1 (LRH-1; NR5A2)* inverse agonist with an IC₅₀ of 3.7 µM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1; IC₅₀>10 µM). ML-180 has the potential for LRH-1-dependent cancers ^[1] .

HY-131445A

SS-RJW100	Others	Metabolic Disease Inflammation/Immunology
SS-RJW100 is a enantiomer of RJW100, which is a racemic agonist of nuclear receptor liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1). SS-RJW100 promotes recruitment of coregulator protein fragments in vitro, recruits the transcriptional intermediary factor 2 (Tif2) coactivator to LRH-1. SS-RJW100 diminishes LRH-1 allosteric activation networks, shows poor thermal stability ^[1] .

HY-128207

SID7970631	Others	Cancer
SID7970631, as an isoquinolinone analog, is a potent and selective submicromolar *SF-1* inhibitor (IC₅₀=255 nM). SID7970631 can be used for the research of cancer ^[1] .

HY-148259

SF-1 antagonist-1	Others	Cancer
SF-1 antagonist-1 (compound 11) is a antagonist of steroidogenic factor 1 (SF-1). SF-1 antagonist-1 affects SF-1 transcriptional activity with an EC₅₀ value of ＜200 nM. SF-1 antagonist-1 inhibits the proliferation of Rat Leydig tumor cells. SF-1 antagonist-1 can be used for the research of cancer ^[1].

HY-RS12756

SF1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SF1 Human Pre-designed siRNA Set A contains three designed siRNAs for SF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SF1 Human Pre-designed siRNA Set A SF1 Human Pre-designed siRNA Set A

HY-131445

RJW100	MicroRNA	Endocrinology Cancer
RJW100 is a potent *liver receptor homolog 1 (LRH-1, NR5A2)* and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC₅₀s of 6.6 and 7.5, respectively ^[1]. RJW100 also causes strong activation of the miR-200c (miRNA-200c, microRNA-200c) promoter .

HY-155168

Iso-RJW100	Others	Cancer
Iso-RJW100 (compound 24-endo) is a dual-liver receptor homologue-1 (LRH-1) and steroidogenic factor-1 (SF-1) agonist with pEC₅₀ of 6.4 and 7.2, respectively ^[1].

HY-RS14606

TM4SF1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TM4SF1 Human Pre-designed siRNA Set A contains three designed siRNAs for TM4SF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TM4SF1 Human Pre-designed siRNA Set A TM4SF1 Human Pre-designed siRNA Set A

HY-153736

NSC 194308	Others	Cancer
NSC 194308, a U2AF2-RNA complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2). NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations ^[1].

HY-129372

PDdB-Pfp	ADC Linker	Cancer
PDdB-Pfp is a cleavable ADC linker used for the agents that target for the extracellular loop 1 (ECL1) of TM4SF1 (transmembrane 4 L6 family member 1) ^[1].

HY-129359

PDP-Pfp	ADC Linker	Cancer
PDP-Pfp is a reducible ADC linker used for the agents that target for the extracellular loop 1 (ECL1) of *TM4SF1* (transmembrane 4 L6 family member 1) ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P990521

Anti-TM4SF1 Antibody	Inhibitory Antibodies	Inflammation/Immunology

Species:	Human (2) Cynomolgus (1)
Tag:	His (2) Strep (1) Tag Free (1)
Source:	HEK293 (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P703128

	NR5A1 Protein, Human (His, Strep) AD4BP; FTZF1; SF1	Human	E. coli
	NR5A1 Protein, Human (His, Strep) is the recombinant human-derived NR5A1, expressed by E. coli , with Strep, His labeled tag. ,

HY-P700837

	TM4SF1 Protein-VLP, Human (HEK293) M3S1; TAAL6; H-L6; L6	Human	HEK293
	TM4SF1 Protein-VLP, Human (HEK293) is recommended for animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.

HY-P702595

	TM4SF1 Protein-VLP, Cynomolgus (HEK293, His) M3S1; TAAL6; H-L6; L6	Cynomolgus	HEK293
	TM4SF1 Protein-VLP, Cynomolgus (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83141

	*Tat SF1* Antibody (YA2886)** HTATSF1; HTSF1; TAT SF1	WB, IHC-P, ICC/IF, IP	Human, Mouse
	Tat SF1 Antibody (YA2886) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2886), targeting Tat SF1, with a predicted molecular weight of 86 kDa (observed band size: 140 kDa). Tat SF1 Antibody (YA2886) can be used for WB, IHC-P, ICC/IF, IP experiment in human, mouse background.

HY-P83421

	Steroidogenic Factor 1 Antibody (YA3166) AD4BP; ELP; FTZ1; FTZF1; hSF 1; NR5A1; POF7; SF1; SPGF8; SRXY3; STF1; SF-1	WB	Human, Mouse, Rat
	Steroidogenic Factor 1 Antibody (YA3166) is a biotin-conjugated non-conjugated IgG antibody, targeting Steroidogenic Factor 1, with a predicted molecular weight of 52 kDa. Steroidogenic Factor 1 Antibody (YA3166) can be used for WB experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-RS12756

SF1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
SF1 Human Pre-designed siRNA Set A contains three designed siRNAs for SF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14606

TM4SF1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
TM4SF1 Human Pre-designed siRNA Set A contains three designed siRNAs for TM4SF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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