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NSC 194308, a U2AF2-RNA complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2). NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations.

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NSC 194308 Chemical Structure

NSC 194308 Chemical Structure

CAS No. : 90379-42-3

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Description

NSC 194308, a U2AF2-RNA complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2). NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations[1].

Molecular Weight

306.44

Formula

C12H22N2O3S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N=C(CS[S](=O)(O)=O)NC[C@@H]1C(CC2CC1)C2(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (163.16 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2633 mL 16.3164 mL 32.6328 mL
5 mM 0.6527 mL 3.2633 mL 6.5266 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2633 mL 16.3164 mL 32.6328 mL 81.5820 mL
5 mM 0.6527 mL 3.2633 mL 6.5266 mL 16.3164 mL
10 mM 0.3263 mL 1.6316 mL 3.2633 mL 8.1582 mL
15 mM 0.2176 mL 1.0878 mL 2.1755 mL 5.4388 mL
20 mM 0.1632 mL 0.8158 mL 1.6316 mL 4.0791 mL
25 mM 0.1305 mL 0.6527 mL 1.3053 mL 3.2633 mL
30 mM 0.1088 mL 0.5439 mL 1.0878 mL 2.7194 mL
40 mM 0.0816 mL 0.4079 mL 0.8158 mL 2.0396 mL
50 mM 0.0653 mL 0.3263 mL 0.6527 mL 1.6316 mL
60 mM 0.0544 mL 0.2719 mL 0.5439 mL 1.3597 mL
80 mM 0.0408 mL 0.2040 mL 0.4079 mL 1.0198 mL
100 mM 0.0326 mL 0.1632 mL 0.3263 mL 0.8158 mL
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NSC 194308 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC 19430890379-42-3NSC194308NSC-194308OthersU2AF2-RNAU2AF1-U2AF2-SF1-spliceRRM1RRM2pre-mRNAU2AFU2 snRNPleukemia cellspliceosome mutationsInhibitorinhibitorinhibit

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